A5100462865- Gastric Cancer Management and Outcomes
- Colorectal Cancer Treatments and Studies
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Cancer Genomics and Diagnostics
- Cancer Immunotherapy and Biomarkers
- Lung Cancer Treatments and Mutations
- Genetic factors in colorectal cancer
- Lymphoma Diagnosis and Treatment
- Pancreatic and Hepatic Oncology Research
- Head and Neck Cancer Studies
- Cancer survivorship and care
- Palliative Care and End-of-Life Issues
- PI3K/AKT/mTOR signaling in cancer
- Metastasis and carcinoma case studies
- Cancer Mechanisms and Therapy
- Hepatocellular Carcinoma Treatment and Prognosis
- Monoclonal and Polyclonal Antibodies Research
- Viral-associated cancers and disorders
- HER2/EGFR in Cancer Research
- Cancer Diagnosis and Treatment
- Epigenetics and DNA Methylation
- Cancer Treatment and Pharmacology
- Chronic Lymphocytic Leukemia Research
- Cancer Cells and Metastasis
- Inflammatory Biomarkers in Disease Prognosis
Seoul National University Bundang Hospital
2016-2025
Seoul National University
2013-2025
Ewha Womans University
2012-2025
Ajou University
2023-2025
Cornell University
2024
Kangwon National University
2024
Weill Cornell Medicine
2024
National University College
2016-2023
New Generation University College
2013-2023
Seoul National University Hospital
2010-2023
Radiotherapy (RT) is a highly effective multimodal nonsurgical treatment that essential for patients with advanced colorectal cancer (CRC). Nevertheless, cell subpopulations displaying intrinsic radioresistance survive after RT. The reactivation of their proliferation and successful colonization at local or distant sites may increase the risk poor clinical outcomes. Recently, radioresistant cells surviving RT were reported to exhibit more aggressive phenotype than parental cells, although...
Scope Although sarcopenia is mainly caused by aging, due to obesity has become an emerging issue given the increase in among people of various ages. There are studies on or sarcopenia, our understanding obesity‐mediated insufficient. Luteolin (LU) exhibited antiobesity effects, but no have investigated LU effects antisarcopenia. This study therefore obese mice with high‐fat diet (HFD)‐induced obesity. Methods and results To evaluate its inhibitory efficacy against 5‐week‐old fed HFD...
Currently, there is no validated therapeutic target for biliary tract cancer (BTC). This study aimed to investigate the pre-clinical and clinical implication of HER2 as a in BTC. We established two novel HER2-amplified BTC cell lines, SNU-2670 SNU-2773, from gallbladder patients. SNU-2773 cells were sensitive trastuzumab, dacomitinib, afatinib compared with nine HER2-negative lines. Dacomitinib led G1 cycle arrest apoptosis cells. Furthermore, afatinib, trastuzumab showed synergistic...
Purpose Programmed death-1 (PD-1)/PD-1 ligand (PD-L1) axis blockades have revolutionized the treatment of advanced non-small cell lung cancer (NSCLC). We assessed effect platinum-based chemotherapy on tumor PD-L1 expression and its clinical implications. Materials Methods used immunohistochemistry to retrospectively evaluate percentage cells with membranous staining (tumor proportion score) in paired specimens obtained before after neoadjuvant (NACT) 86 patients NSCLC. analyzed correlation...
Background and Purpose— Atrial fibrillation (AF) is increasingly recognized as the single most important cause of disabling ischemic stroke in elderly. We undertook an international survey to characterize frequency AF-associated stroke, methods AF detection, patient features. Methods— Consecutive patients hospitalized for 2013 2014 were surveyed from 19 research centers different countries. Data analyzed by global regions World Bank income levels. Results— Of 2144 with 590 (28%; 95%...
We evaluated the efficacy and safety of avelumab, an anti-PD-L1 antibody, in patients with metastatic or unresectable colorectal cancer (mCRC) mismatch repair deficiency (dMMR)/microsatellite instability-high (MSI-H) POLE mutations.
Background Bispecific T-cell engagers (BTEs) are novel agents used to treat hematological malignancies. Early trials were underpowered define cardiovascular adverse events (CVAE) and no large-scale studies systematically examined the CVAEs associated with BTEs. Methods Leveraging US Food Drug Administration’s Adverse Event Reporting System-(FAERS), we identified relative frequency of after initiation five BTE products approved by Administration between 2014 2023 for treatment Adjusted...
Few studies have been conducted on sex differences in the incidence, pathophysiology, and prognosis of gastric cancer (GC).To analyze GC characteristics according to patients who underwent surgical treatment for GC.A total 2983 diagnosed with adenocarcinoma received at Seoul National University Bundang Hospital between 2003 2017 were included. Baseline clinicopathological characteristics, histologic type GC, overall GC-specific survival rates, associated risk factors analyzed.Among patients,...
Abstract Tumor-infiltrating lymphocytes (TIL) have been suggested as an important prognostic marker in colorectal cancer, but assessment usually requires additional tissue processing and interpretational efforts. The aim of this study is to assess the clinical significance artificial intelligence (AI)-powered spatial TIL analysis using only a hematoxylin eosin (H&E)-stained whole-slide image (WSI) for prediction prognosis stage II–III colon cancer treated with surgery adjuvant therapy....
Purpose Vascular endothelial growth factor (VEGF)-A, VEGF165b, interleukin (IL)-1β, and transforming (TGF)-β1 are known to influence tumor angiogenesis. Clinical implications of these cytokines need be elucidated. Materials Methods Using clinical data baseline serum samples 140 consecutive patients with advanced non-small cell lung cancer who received platinum-based combination chemotherapy, we investigated the association among cytokine levels, treatment outcomes, as well leukocyte...
Abstract The purpose of this study was to evaluate the prognostic impact major histocompatibility complex (MHC) class I expression and programmed death-ligand 1 (PD-L1) in patients with head neck squamous cell carcinoma (HNSCC). A total 158 HNSCC were evaluated retrospectively. MHC PD-L1 analyzed tumor specimens using immunohistochemistry. association between I/PD-L1 clinical outcome by Kaplan-Meier Cox regression analyses. Among patients, 103 (65.2%) showed positive expression, 20 (12.7%)...
Purpose Head and neck squamous cell carcinoma (HNSCC) is a deadly disease in which precision medicine needs to be incorporated. We aimed implement next-generation sequencing (NGS) determining actionable targets guide appropriate molecular targeted therapy HNSCC patients. Materials Methods Ninety-three tumors matched blood samples underwent of 244 genes using the Illumina HiSeq 2500 platform with an average depth coverage greater than 1,000×. Clinicopathological data from patients were...
Next-generation sequencing (NGS) cancer profiling has gained traction in routine clinical practice South Korea. Here, we evaluated the use of NGS testing and genomically-matched therapies for patients with advanced solid tumors a real-world practice. We analyzed results from panel tests (SNUBH pan-cancer version 2) ordered June 2019 to 2020. Genomically-matched treatment was determined based on novel information obtained testing, while conventional molecular were excluded. A total 990...
Abstract Background Three dimensional (3D) cell cultures can be effectively used for drug discovery and development but there are still challenges in their general application to high-throughput screening. In this study, we developed a novel chemotherapeutic 3D screening system gastric cancer, named 'Cure-GA', discover clinically applicable anticancer drugs predict therapeutic responses. Methods Primary cancer cells were isolated from 143 fresh surgical specimens by enzymatic treatment....
Polymyalgia rheumatica (PMR) is a chronic inflammatory rheumatic disease affecting older adults, with symptoms often overlapping those of other conditions, thus making its diagnosis challenging. The present study evaluated the utility laboratory-based scores, including systemic immune-inflammation index (SII), C-reactive protein-to-albumin ratio (CAR), albumin-to-globulin (AGR), and prognostic nutritional (PNI), as diagnostic tools for PMR explored their association clinical manifestations....
Purpose Older cancer patients face unique challenges due to age-related physiological changes, increasing their vulnerability treatment-related toxicities. Geriatric assessment (GA) is a validated tool for optimizing care, yet there no consensus on integrating geriatric interventions into oncology. This study evaluates the feasibility of tailored onco-geriatric intervention model incorporating KG-7 screening tool. Materials and Methods prospective included 30 aged ≥70 years with solid tumors...
The male predominance in the incidence of gastric cancer (GC) is established; however, sex differences prognosis GC remain controversial. As such, this study analyzed patients with based on age and sex. Data from 14,739 diagnosed at Seoul National University Bundang Hospital between 2003 2023 were analyzed. Baseline characteristics, histological types GC, overall GC-specific survival rates (age stage stratification), associated risk factors Females significantly younger (p < 0.001) exhibited...