A5004917289- Liver Disease Diagnosis and Treatment
- Hepatitis C virus research
- Hepatitis B Virus Studies
- Liver Disease and Transplantation
- Hepatocellular Carcinoma Treatment and Prognosis
- HIV/AIDS drug development and treatment
- Sesquiterpenes and Asteraceae Studies
- Hepatitis Viruses Studies and Epidemiology
- Gallbladder and Bile Duct Disorders
- Gastric Cancer Management and Outcomes
- Drug-Induced Hepatotoxicity and Protection
- Natural product bioactivities and synthesis
- Pancreatic and Hepatic Oncology Research
- Gastrointestinal Tumor Research and Treatment
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Gastrointestinal disorders and treatments
- Genetic factors in colorectal cancer
- Pediatric Hepatobiliary Diseases and Treatments
- Cancer-related molecular mechanisms research
- MicroRNA in disease regulation
- Cancer, Lipids, and Metabolism
- Enzyme Production and Characterization
- Liver Diseases and Immunity
- Studies on Chitinases and Chitosanases
- Pancreatitis Pathology and Treatment
Chonbuk National University Hospital
2016-2025
Jeonbuk National University
2016-2025
National University College
2016-2024
New Generation University College
2016-2024
Inje University
2024
National Cancer Center
2024
Soonchunhyang University
2016-2024
Keimyung University
2024
Inje University Ilsan Paik Hospital
2024
Chonnam National University Hwasun Hospital
2024
To address a growing concern about drug-induced liver injury (DILI), nationwide study was performed to investigate the significance of DILI in Korea.From May 2005 2007, cases (alanine transferase > 3 × upper normal limit or total bilirubin 2 limit) from 17 referral university hospitals were prospectively enrolled. Adjudication by seven review boards considered for confirmation causality and Roussel Uclaf Causality Assessment Method (RUCAM) scale used.A 371 diagnosed with DILI. The...
Table 1.Grading evidence and recommendations Evidence Notes High quality Further research is very unlikely to change our confidence in the estimate of effect A Moderate likely have an important impact on may B Low estimate.Any uncertain C Recommendation Strong Factors influencing strength recommendation included evidence, presumed patient-important outcomes, cost 1 Weak Variability preferences values, or more uncertainty.Recommendation made with less certainty, higher resource consumption 2
Staphylococcus aureus (S. aureus) causes persistent biofilm-related infections. Biofilm formation by S. is affected the culture conditions and associated with certain genotypic characteristics. Here, we show that glucose sodium chloride (NaCl) supplementation of media, a common practice in studies biofilms vitro, influences both biofilm 40 clinical isolates (methicillin-resistant methicillin-sensitive variations quantification. Methicillin-resistant strains formed more robust than tryptic...
The aim of this study was to reveal nationwide seroprevalence HCV infection in South Korea by a large-scale survey.From January December 2009, total 291 314 adults underwent health check-up 29 centres nationwide. data concerning anti-HCV antibody and biochemical tests were obtained from all participants. Among subjects with positive anti-HCV, such as RNA, genotypes treatment detail additionally analysed.Using an estimated 2009 population Korea, the age, sex area-adjusted rate 0.78%. Anti-HCV...
Background/Aim: Delayed bleeding is a serious complication that occurs after polypectomy. Many risk factors for delayed have been suggested, but there little analysis of procedure-related factors. The purpose this study to identify wide range postpolypectomy (DPPB) and analyze the correlations those potential DPPB Materials Methods: In retrospective cohort study, 5981 polypectomies in 3788 patients were evaluated between January 2010 February 2012. Patient-related, polyp-related, as Results:...
Transient elastography (TE) has become an alternative to liver biopsy (LB). This study investigated the diagnostic performance of stiffness (LS) measurement using TE in Korean patients with chronic hepatitis B and C (CHB CHC).From April 2006 June 2014, 916 (567 CHB 349 CHC) who underwent LB at 15 centres were analyzed. The Batts Ludwig scoring system was used for histologic assessment. Aspartate aminotransferase (AST)-to-platelet ratio indexes (APRI) calculated. Area under receiver operating...
Transmembrane-4-L6 family 1 (TM4SF1) is upregulated in colorectal carcinoma (CRC). However, the mechanism leading to inhibition of TM4SF1 not known. In present study, we investigated regulation and function microRNAs (miRNAs) CRC invasion metastasis. We analyzed 60 colon cancers paired normal specimens for miRNA-9 (miR-9) expression using quantitative real-time PCR. A bioinformatics analysis identified a putative miR-9 binding site within 3'-UTR TM4SF1. also found that was tissues cell...
Summary Background Anti‐viral therapy is not indicated for patients with chronic hepatitis B (CHB) in the immune‐tolerant phase. Aims To investigate cumulative incidence of phase change and hepatocellular carcinoma (HCC) independent predictors CHB Methods In total, 946 phase, defined as e antigen positivity, HBV‐DNA >20 000 IU/mL alanine aminotransferase (ALT) ≤40 IU/L, between 1989 2017 were enrolled from eight institutes. Results The mean age study population (429 men 517 women) was...
Using messenger RNA (mRNA) differential display, we identified a single complementary DNA (cDNA) fragment (HG23T1) that was over-expressed in hepatocellular carcinoma (HCC) specimen. We cloned the full-length HG23T1 gene by rapid amplification of cDNA end (RACE) polymerase chain reaction (PCR) method. It perfectly matched encoding human ribosomal protein L36a (RPL36A also referred to as RPL44). RPL36A mRNA preferentially 34 40 HCC cases (85%, P <.001) and all 8 cell lines. Ectopically...
Evidence of the potential benefits long-term oral branched-chain amino acid (BCAA) supplementation in reducing severity liver disease is limited.Patients who were diagnosed with cirrhosis a Child-Pugh (CP) score 8-10 included. The BCAA group consumed BCAAs daily for at least 6 months, and control diet without BCAA. We analyzed improvements based on model end-stage (MELD) score, CP incidence cirrhosis-related complications, event-free survival over 2 years. Among 867 recruited patients, 307...
MiRNA (miR)-206 plays a tumor suppressor role in various cancer types. Here, we investigated whether miR-206 is involved prostaglandin E2 (PGE2)-induced epithelial–mesenchymal transition (EMT) colorectal (CRC) cells through the targetting of transmembrane 4 L six family member 1 (TM4SF1). The effect PGE2 on growth and apoptosis CRC was evaluated using MTT assay flow cytometry analysis, respectively. TM4SF1 expression levels were determined with quantitative polymerase chain reaction...
Clinical evidence for the benefits of branched-chain amino acids (BCAAs) is lacking in advanced liver disease. We evaluated potential long-term oral BCAA supplementation patients with disease.Liver cirrhosis Child-Pugh (CP) scores from 8 to 10 were prospectively recruited 13 medical centers. Patients supplemented 12.45 g daily granules over 6 months, and consuming a regular diet assigned control groups, respectively. The effects using model end-stage disease (MELD) score, CP serum albumin,...
Abstract Background/aims This study aimed to investigate the factors associated with prolonged hospital stay and in-hospital mortality in patients pyogenic liver abscess. Methods We retrospectively reviewed data from abscess who were admitted between 2005 2018 at three tertiary hospitals Jeonbuk province, South Korea. Prolonged was defined as a duration of admission more than 21 days. Results A total 648 (406 men 242 women) diagnosed enrolled study. The mean maximal diameter 5.4 ± 2.6 cm,...
Background/AimsBesifovir (BSV) showed comparable antiviral activity superior safety profiles to tenofovir disoproxil fumarate (TDF) in treatment-naïve chronic hepatitis B (CHB).However, no data are available regarding the efficacy and of BSV patients with CHB who switched from long-term TDF BSV.This study aimed evaluate outcome a 48-week therapy treatment. MethodsIn this non-inferiority trial, 153 treated for ≥48 weeks had virus (HBV) DNA <20 IU/mL were randomized receive either 150 mg or...
Background/Aims: To eliminate hepatitis B virus (HBV) and C (HCV) according to the World Health Organization (WHO) criteria in 2021, this study investigated national core indicators representing current status of viral South Korea.Methods: We analyzed incidence, linkage-to-care, treatment, mortality rates HBV HCV infection using integrated nationwide big data Korea.Results: According from 2018–2020, incidence acute Korea was 0.71 cases per 100,000 population; tthe linkage-to-care rate only...
Abstract Background Three dimensional (3D) cell cultures can be effectively used for drug discovery and development but there are still challenges in their general application to high-throughput screening. In this study, we developed a novel chemotherapeutic 3D screening system gastric cancer, named 'Cure-GA', discover clinically applicable anticancer drugs predict therapeutic responses. Methods Primary cancer cells were isolated from 143 fresh surgical specimens by enzymatic treatment....
Background/Aims Acute decompensation (AD) is defined as the development of complications related to portal hypertension and liver dysfunction that affect progression chronic disease (CLD) or cirrhosis (LC). Variations exist in patient demographics prognostic outcomes AD based on aetiology CLD, encompassing LC. However, limited research has been conducted analyse these discrepancies across aetiologies.
Hepatitis C virus (HCV) infection causes extrahepatic manifestations involving B-cell dysregulation and autoantibody production. This study aimed to elucidate the positivity rates of four autoantibodies [anti-nuclear antibody (ANA), anti-smooth muscle (ASMA), anti-liver kidney microsomal type 1 (anti-LKM1), anti-mitochondrial (AMA)] in patients with chronic hepatitis (CHC) before after direct-acting antiviral (DAA) therapy compared those healthy controls. enrolled prospectively collected...