A5047671718- Gastric Cancer Management and Outcomes
- Gastrointestinal Tumor Research and Treatment
- Metastasis and carcinoma case studies
- Cancer Genomics and Diagnostics
- Inhalation and Respiratory Drug Delivery
- Intraperitoneal and Appendiceal Malignancies
- Colorectal Cancer Surgical Treatments
- Cancer Cells and Metastasis
- 3D Printing in Biomedical Research
- Esophageal and GI Pathology
- Ultrasound and Hyperthermia Applications
- Cancer Mechanisms and Therapy
- Pain Management and Opioid Use
- Antiplatelet Therapy and Cardiovascular Diseases
- Ferroptosis and cancer prognosis
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Neuroendocrine Tumor Research Advances
- Enhanced Recovery After Surgery
- Papaya Research and Applications
- Pediatric Pain Management Techniques
- RNA modifications and cancer
- Chemical Thermodynamics and Molecular Structure
- Cancer and biochemical research
- Innovative Microfluidic and Catalytic Techniques Innovation
- Thermal and Kinetic Analysis
Seoul National University Bundang Hospital
2022-2025
Chung-Ang University
2023
Kookmin University
2003
Abstract Background Three dimensional (3D) cell cultures can be effectively used for drug discovery and development but there are still challenges in their general application to high-throughput screening. In this study, we developed a novel chemotherapeutic 3D screening system gastric cancer, named 'Cure-GA', discover clinically applicable anticancer drugs predict therapeutic responses. Methods Primary cancer cells were isolated from 143 fresh surgical specimens by enzymatic treatment....
This study aimed to evaluate the outcomes and current status of reduced-port laparoscopic distal gastrectomy (RLDG) compared with multiport (MLDG) based on a 2019 nationwide survey surgical gastric cancer treatments by Korean Gastric Cancer Association (KGCA). The was conducted retrospectively from March December 2020 using data KGCA database. To compare RLDG MLDG age, sex, body mass index, American Society Anesthesiologists score, histological type, tumor invasion, lymph node metastasis,...
Abstract Advancements in minimally invasive surgery has led to the development of several surgical instruments, including ArtiSential®. This new instrument provides a greater range motion and improved dexterity laparoscopic procedures, making it an alternative option traditional straight Da Vinci robot system. The purpose this study is compare postoperative outcomes prospective cohort patients who underwent gastrectomy using articulating instruments with those historical same procedure...
Abstract Metastatic gastric cancer (GC) presents significant clinical challenges due to its poor prognosis and limited treatment options. To address this, we conducted a targeted protein biomarker discovery study identify markers predictive of metastasis in advanced GC (AGC). Serum samples from 176 AGC patients (T stage 3 or higher) were analyzed using the Olink Proteomics Target panels. Patients retrospectively categorized into nonmetastatic, metastatic, recurrence groups, differential...
Abstract Extrachromosomal DNA (ecDNA) drives substantial copy number increases in focal regions harboring oncogenes and its non-Mendelian inheritance during mitosis contributes to cancer heterogeneity a poor prognosis across multiple types. However, the prevalence function of ecDNA gastric (GC) are still largely unknown. Here, we profiled by whole-genome sequencing analysis from 76 GC patients explored functional attributes through whole-transcriptome same tissues. Focal somatic...
Bariatric surgery is the gold standard for treatment of morbid obesity, but postoperative pain impedes recovery. Currently available pain-recovery treatments have patient safety concerns. This led to a noninferiority study Welpass (Genewel Co., Ltd.)
The use of antiplatelet and/or anticoagulant therapies has become common. In rare cases, these may increase the risk dangerous postoperative bleeding. We investigated association antiplatelets anticoagulants with major bleeding in laparoscopic gastric cancer surgery.We retrospectively enrolled 3,663 patients (antiplatelet/anticoagulant group, 518; control 3,145) who had undergone surgery between January 2012 and December 2017. To minimize selection bias, 508 each group were matched using...
Abstract Purpose: The advancement in minimally invasive surgery has led to the development of several surgical instruments, including ArtiSential®. This new instrument provides a greater range motion and improved dexterity laparoscopic procedures, making it an alternative option traditional straight instruments Da Vinci system. purpose this study is compare postoperative outcomes prospective cohort patients who underwent gastrectomy using articulating with those historical same procedure...
The intraoperative estimated blood loss (EBL), an essential parameter for perioperative management, has been evaluated by manually weighing in gauze and suction bottles, a process both time-consuming labor-intensive. As the novel EBL prediction platform, we developed automated deep learning model, utilizing patch-wise crumpled state (P-W CS) of images with texture analysis. proposed algorithm was using animal data obtained from porcine experiment validated on human prospectively collected...
Peritoneal carcinomatosis (PC) presents a major challenge in the treatment of late-stage, solid tumors, with traditional therapies limited by poor drug penetration. We evaluated novel hyperthermic pressurized intraperitoneal aerosol chemotherapy (HPIPAC) system using human abdominal cavity model for its efficacy against AGS gastric cancer cells.
Abstract Background The technical challenges and safety concerns of single-incision laparoscopic gastrectomy for overweight obese gastric cancer patients remain unclear. This study aimed to evaluate the feasibility distal (SIDG) compared multiport (MLDG) in patients. Methods retrospectively analyzed (body mass index ≥ 25 kg/m 2 ) pathologic stage T1 primary adenocarcinoma treated with either SIDG or MLDG. MLDG groups were propensity score matched at a 1:2 ratio using age, sex, height, body...
Abstract To discover clinically applicable anticancer drugs and predict therapeutic response for advanced gastric cancer, we developed a high-throughput drug (HTD) screening system that could rapidly evaluate reactivity using 3D cultured primary cells derived from cancer (GC) patients. Primary were isolated fresh surgical specimens resected 143 GC patients Gentle Max tissue dissociation system. mixed with Matrigel, placed on micropillar three-dimensional (3D) culture. After the stabilized in...
Abstract Introduction: Nutritional deficiency and weight loss after gastrectomy are important detrimental factors for gastric cancer survivorship, which is avoided by endoscopic resection (ER). On the other hand, chronic metabolic or cardiovascular diseases in long term survivors may require appropriate reduction. The purpose of this study to evaluate survival, cumulative incidence, medical expenses between who underwent ER using Korean National Health Insurance (KNHI) database. Methods: Big...
According to the American Joint Committee on Cancer cancer staging system, positive peritoneal washing cytology (PWC) indicates stage IV gastric cancer. However, rapid intraoperative diagnosis of PWC has no established reliable method. This study evaluated and compared diagnostic accuracy Shorr modified ultrafast Papanicolaou (MUFP) methods for PWC.This included patients with who were clinically diagnosed cT3 or higher. The MUFP performed all specimens, results those conventional (PAP)...