A5101847265- Reproductive Biology and Fertility
- Ovarian function and disorders
- Reproductive Health and Technologies
- Ovarian cancer diagnosis and treatment
- Endometriosis Research and Treatment
- Assisted Reproductive Technology and Twin Pregnancy
- Reproductive System and Pregnancy
- BRCA gene mutations in cancer
- Cancer Risks and Factors
- Reproductive Health and Contraception
- Gynecological conditions and treatments
- Urinary Bladder and Prostate Research
- COVID-19 and healthcare impacts
- T-cell and B-cell Immunology
- Obstructive Sleep Apnea Research
- Peripheral Neuropathies and Disorders
- Bioactive Compounds and Antitumor Agents
- Lymphatic System and Diseases
- Bone health and treatments
- Genetically Modified Organisms Research
- Optical Coherence Tomography Applications
- Immune Cell Function and Interaction
- COVID-19 Impact on Reproduction
- Maternal and fetal healthcare
- Epilepsy research and treatment
Seoul National University Bundang Hospital
2012-2025
Weatherford College
2024
CHA Bundang Medical Center
2019-2024
CHA University
2005-2024
Maria Fertility Hospital
2024
Regeneron (United States)
2023
University of North Carolina at Chapel Hill
2011-2021
CHA Gangnam Medical Center
2014-2015
New York Medical College
2009-2015
Ewha Womans University Medical Center
2015
BACKGROUNDWhile oncologists are aware that cancer treatments may impact fertility, referral rates for fertility preservation consultation (FPC) remain poor. The goal of this study was to identify predictors associated with FPC referral.
BackgroundHypercalcemia of malignancy (HCM), a major metabolic complication cancer, is often managed with bisphosphonates (BP) and, increasingly, denosumab. We aimed to compare the effectiveness and safety denosumab that BP, or without calcitonin, in treating HCM. MethodsThis retrospective cohort study was conducted at tertiary hospital from 2017 2022 included 317 patients treated for Participants were divided into three treatment groups: denosumab, intravenous (IV) BP only, IV combined...
The common γ chain (γc; IL-2RG) is a subunit of the interleukin (IL) receptors for γc cytokines IL-2, IL-4, IL-7, IL-9, IL-15, and IL-21. lack appropriate neutralizing antibodies recognizing IL-2RG has made it difficult to thoroughly interrogate role in inflammatory autoimmune disease settings. Here, we generated cytokine receptor antibody, REGN7257, determine whether might be targeted T cell–mediated prevention treatment. Biochemical, structural, vitro analysis showed that REGN7257 binds...
Purpose Older cancer patients face unique challenges due to age-related physiological changes, increasing their vulnerability treatment-related toxicities. Geriatric assessment (GA) is a validated tool for optimizing care, yet there no consensus on integrating geriatric interventions into oncology. This study evaluates the feasibility of tailored onco-geriatric intervention model incorporating KG-7 screening tool. Materials and Methods prospective included 30 aged ≥70 years with solid tumors...
Abstract Objective: Impaired fertility and reproductive health after cancer treatment is an important quality-of-life issue among female childhood survivors (CCSs). This study aims to measure CCSs' knowledge about their exposure views counseling (RC). Method: a cross-sectional, web-survey of CCSs aged 18 45 years who were diagnosed with before age 21 currently had no evidence disease. Results: Fifty-six participated (response rate = 48%; mean current 26). Knowledge was severely limited...
Objective A beneficial effect on endometrial thickness (EMT) and improvement of pregnancy outcome after intrauterine infusion platelet-rich plasma (PRP) has been suggested. This study assessed the PRP live birth rate obstetrical outcomes analyzed cytokines that can potentially improve through PRP. Method was a prospective cohort conducted in university hospital fertility center. The included ninety-one patients who had history two or more failed vitro fertilization (IVF) attempts refractory...
BRCA mutation carriers will experience early surgically induced menopause following prophylactic bilateral salpingo-oophorectomy (PBSO). This pilot study aimed to investigate their (1) knowledge about the clinical impact of PBSO; (2) views on fertility consultation (FC)/fertility preservation (FP) treatment; and (3) difficulties in conceiving compared non-carriers. A cross-sectional, single institution web-survey was performed at a university-based IVF center. Women aged 18-50 years who were...
Despite extensive research on implantation failure, little is known about the molecular mechanisms underlying crosstalk between embryo and maternal endometrium, which critical for successful pregnancy. Profilin 1 (PFN1), expressed both in endometrial epithelium, acts as a potent regulator of actin polymerization cytoskeletal network. In this study, we identified specific role PFN1 during implantation.Morphological alterations depending status expression were assessed PFN1-depleted or control...
ABSTRACT A patient with chronic cerebral paragonimiasis began to have new motor seizures of the right face manifested by clonic contractions that occurred several hundred times a day, consistent simple partial status epilepticus. Ictal electroencephalogram discharges started from left frontal region and then spread hemisphere maximum. But clinical were limited face. The frequent controlled intravenous infusion phenytoin. Brain magnetic resonance imaging showed multiple conglomerated round...
The coronavirus disease 2019 (COVID-19) outbreak caused by SARS-CoV-2 (severe acute respiratory syndrome coronavirus-2) has affected various medical fields worldwide. However, relatively few studies have examined the impact of COVID-19 infection and vaccination on in vitro fertilization (IVF) outcomes changes antibody concentration follicular fluid (FF). A total 45 women were prospectively recruited assigned to 3 groups: uninfected non-vaccinated control group (Control group), infected...
Abstract Study question What are the prevalence, associated factors and pregnancy outcome of chronic endometritis(CE) among infertile women? Summary answer The overal prevalence endometritis in women was 24.7%. Diagnosis rate CE higher primary infertility compared to other groups. is known already Chronic defined as a inflammation uterine endometrium. varies across different groups diagnostic criteria. pathophysiology remained unclear, therefore, uncertain. design, size, duration We perfomed...
Abstract: Korea has become the hub of clinical trials in world. Good Clinical Practice was legislated 1995, with an amendment 2001 to adopt International Council Harmonization (ICH)-Good Practive (GCP). New Trial Authorization (CTA) process, which introduced 2002 streamline regulatory process along faster study start up, facilitated registration Korea. Following 2002, number multinational conducted began increase rapidly. It initially centered on late-phase trials, but subsequently moved...
Purpose: To determine the difference in subfoveal choroidal thickness between two spectral-domain optical coherence tomography (SD-OCT) systems normal eyes and with retinal diseases. Methods: Thirty-three 49 disease (13 diabetic retinopathy, 28 epiretinal membrane eight macular hole) were enrolled study. Subfoveal thicknesses measured by 3 observers using enhanced depth imaging technique of Heidelberg Spectralis high-definition five-line raster scan Cirrus HD-OCT calipers within program....
Purpose: To compare the clinical outcomes between refractive-type multifocal intraocular lenses (IOL) (Lentis Mplus ® LS 313, Oculentis GmbH., Berlin, Germany) and diffractive-type IOL (Acrysof Restor ; SN6AD1, Alcon Lab., Fort Worth, TX, USA) with same near added.Methods: We evaluated 30 eyes implanted Lentis 33 Acrysof after phacoemulsification.The distant, intermediate, uncorrected visual acuities of 2 groups were at weeks 1, 3, 6 months postoperatively.Optical quality obtained using...
In vitro fertilization-embryo transfer (IVF-ET), an expensive option for infertile couples, started to be fully covered by the National Health Insurance (NHI) from October 2017 in South Korea. We investigated association between woman's socioeconomic status (SES) and abortive outcomes pregnancies after IVF-ET setting of universal coverage treatment.Using NHI database Korea, we conducted a retrospective cohort study all women who achieved clinical pregnancy ET February 2019. A total 44,038...
Background and Objective Nocturia is one of the common causes sleep disturbance in adults, often associated with obstructive apnea (OSA). The purpose this study was to investigate association between nocturia OSA, their effects on quality adults. Methods This included 107 patients who visited urology outpatient due lower urinary tract symptoms or without sleep-related symptoms, assessed by using either International Prostate Symptom Score men Overactive Bladder women. Based these...