A5039924915- Bone health and osteoporosis research
- Adrenal and Paraganglionic Tumors
- Hormonal Regulation and Hypertension
- Bone Metabolism and Diseases
- Parathyroid Disorders and Treatments
- Bone health and treatments
- Pituitary Gland Disorders and Treatments
- Adrenal Hormones and Disorders
- Semiconductor materials and devices
- Advancements in Semiconductor Devices and Circuit Design
- Vitamin D Research Studies
- Growth Hormone and Insulin-like Growth Factors
- Hormonal and reproductive studies
- Cancer, Hypoxia, and Metabolism
- Genetic Syndromes and Imprinting
- Nutrition and Health in Aging
- Wnt/β-catenin signaling in development and cancer
- Sexual Differentiation and Disorders
- Metabolism, Diabetes, and Cancer
- Peroxisome Proliferator-Activated Receptors
- Pancreatic and Hepatic Oncology Research
- Mesenchymal stem cell research
- Hip and Femur Fractures
- Bone and Joint Diseases
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
Boramae Medical Center
2016-2025
Seoul National University
2016-2025
Seoul Metropolitan Government
2013-2024
New Generation University College
2003-2024
National University College
2012-2024
Korea Advanced Institute of Science and Technology
2024
Samsung Medical Center
2004-2017
Seoul National University Hospital
2003-2017
Sungkyunkwan University
1996-2017
Seoul National University Bundang Hospital
2015
Abstract Intermittent administration of parathyroid hormone (PTH) increases bone mass, at least in part, by increasing the number osteoblasts. One possible source osteoblasts might be conversion inactive lining cells to osteoblasts, and indirect evidence is consistent with this hypothesis. To better understand effect PTH on cell activation, a lineage tracing study was conducted using an inducible gene system. Dmp1-CreERt2 mice were crossed ROSA26R reporter render targeted mature their...
Trabecular bone score (TBS) is a novel texture index that evaluates the pixel gray-level variations in lumbar spine dual-energy X-ray absorptiometry images and related to microarchitecture independent of mineral density (BMD).We investigated TBS as an indicator for skeletal deterioration diabetes.Cross-sectional data were collected from subjects participating ongoing prospective, community-based, cohort study 2009 2010.We included 1229 men 1529 postmenopausal women older than 50 years Ansung...
Sclerostin antibody (Scl-Ab) increases osteoblast activity, in part through increasing modeling-based bone formation on previously quiescent surfaces. Histomorphometric studies have suggested that this might occur conversion of lining cells into active osteoblasts. However, direct data demonstrating Scl-Ab-induced osteoblasts are lacking. Here, we used vivo lineage tracing to determine if Scl-Ab promotes the periosteal and endocortical surfaces mice. Two independent, tamoxifen-inducible...
Background Patients have the highest risk of subsequent fractures in first few years after an initial fracture, yet models to predict short-term not been developed. Purpose To develop and validate a deep learning prediction model for fracture using digitally reconstructed radiographs from hip CT patients with recent fractures. Materials Methods This retrospective study included adult who underwent three-dimensional due January 2004 December 2020. Two-dimensional frontal, lateral, axial were...
ABSTRACT Farnesoid X receptor (FXR) is a nuclear that functions as bile acid sensor controlling homeostasis. We investigated the role of FXR in regulating bone metabolism. identified expression calvaria and marrow cells, which gradually increased during osteoblastic differentiation vitro. In male mice, deletion (FXR−/−) vivo resulted significant reduction mineral density by 4.3% to 6.6% mice 8 20 weeks age compared with FXR+/+ mice. Histological analysis lumbar spine showed deficiency...
Aminopyrazoles are a new class of antimalarial compounds identified in cellular antiparasitic screen with potent activity against Plasmodium falciparum asexual and sexual stage parasites. To investigate their unknown mechanism action thus identify target, we cultured parasites the presence representative member aminopyrazole series, GNF-Pf4492, to select for resistance. Whole genome sequencing three resistant lines showed that each had acquired independent mutations P-type cation-transporter...
Little is known about the interactions between dietary calcium intake and bone strength parameters in populations or areas with low intake.The objective of study was to investigate relationship mineral density (BMD) geometry an Asian population intake.This a cross-sectional data from Korea National Health Nutrition Examination Survey, 2008-2010.A total 3448 men 3812 women older than 50 years were stratified by daily intake: less 400 mg/d, 400-799 800-1199 1200 mg/d greater.BMD measured...
Peroxisome proliferator-activated receptor γ (PPARγ) is a member of the nuclear superfamily. It functions as ligand-activated transcription factor and plays important roles in regulation adipocyte differentiation, insulin resistance, inflammation. Here, we report crystal structures PPARγ complex with lobeglitazone, novel agonist, rosiglitazone for comparison. The thiazolidinedione (TZD) moiety lobeglitazone occupies canonical ligand-binding pocket near activation function-2 (AF-2) helix...
The prevalence of silent corticotroph adenomas (SCAs) is not rare among nonfunctioning pituitary (NFPAs); however, it unknown whether the clinical significance SCAs differs from that NFPAs without ACTH immunoreactivity (non-SCAs). Our goal was to compare characteristics and natural history between patients with non-SCAs.We reviewed medical records all who underwent transsphenoidal surgery for January 1990 October 2007 at Seoul National University Hospital.We analysed manifestations...
Osteoporosis is a systemic skeletal disorder characterized by reduced bone mineral density (BMD) and increased risk of fracture. We studied the effects transplantation mesenchymal stem cells (MSCs) overexpressing receptor activator nuclear factor-kappaB (RANK)-Fc CXC chemokine receptor-4 (CXCR4) using retrovirus on ovariectomy (OVX)-induced loss in mice. Ten-week-old adult female C57BL/6 mice were divided into six groups as follows: Sham-operated treated with phosphate-buffered saline (PBS)...
ABSTRACT Growing evidence shows the possibility of a role microRNAs (miRNA) in regulating bone mass. We investigated change miRNAs and mRNA expression profiles tissue an ovariectomized mice model evaluated regulatory mechanism mass mediated by estrogen-deficiency state. Eight-week-old female C3H/HeJ underwent ovariectomy (OVX) or sham operation (Sham-op), their femur tibia were harvested to extract total RNAs after 4 weeks for microarray analysis. Eight (miR-127, -133a, -133a*, -133b, -136,...
This study was conducted to review the clinical characteristics of parathyroid carcinoma (PC) and evaluate potential preoperative predictive factors for PC in patients with primary hyperparathyroidism (PHPT). We performed a retrospective electronic medical records 194 pathologically confirmed PHPT affiliated teaching hospitals Seoul National University from January 2000 March 2011. Adenoma diagnosed 171 patients, hyperplasia 12, 11. Several biochemical measurements were higher than benign...
Osteoblasts are derived from mesenchymal progenitors. Differentiation to osteoblasts and adipocytes is reciprocally regulated. Transcriptional coactivator with a PDZ-binding motif (TAZ) transcriptional that induces differentiation of cells into while blocking adipocytes. To investigate the role TAZ on bone metabolism in vivo, we generated transgenic mice overexpress under control procollagen type 1 promoter (Col1-TAZ). Whole body mineral density (BMD) 6- 19-week-old Col-TAZ was 4% 7% higher...
Recently, the European Society of Endocrinology (ESE), in collaboration with Network for Study Adrenal Tumors (ENSAT), asserted that adrenal incidentalomas (AIs) <4 cm and ≤10 Hounsfield units (HU) do not require further follow-up imaging. To validate clinical application strategies suggested by 2016 ESE-ENSAT guidelines, we explored characteristics natural course AIs a single center over 13 years.This retrospective cohort study included total 1149 patients diagnosed between 2000 2013...