A5044205404- Adipose Tissue and Metabolism
- Ubiquitin and proteasome pathways
- Peroxisome Proliferator-Activated Receptors
- Vitamin K Research Studies
- Metabolism, Diabetes, and Cancer
- Vitamin C and Antioxidants Research
- Cancer, Hypoxia, and Metabolism
- Peptidase Inhibition and Analysis
- Semiconductor materials and interfaces
- Pancreatic function and diabetes
- Diet and metabolism studies
- Mitochondrial Function and Pathology
- Wnt/β-catenin signaling in development and cancer
- Microstructure and mechanical properties
- Plant Molecular Biology Research
- Diabetes Treatment and Management
- Genetics and Neurodevelopmental Disorders
- RNA Research and Splicing
- Cancer-related gene regulation
- Pharmacological Effects of Natural Compounds
- Anodic Oxide Films and Nanostructures
- Calcium Carbonate Crystallization and Inhibition
- FOXO transcription factor regulation
- Metabolism and Genetic Disorders
- Phytoestrogen effects and research
University of Ulsan
2022-2025
Cardiovascular Institute Hospital
2019
Jeonbuk National University
2009-2019
Philadelphia University
2019
Seoul National University
2009-2018
International Society for Developmental Origins of Health and Disease
2016
Chonbuk National University Hospital
2015
Government of the Republic of Korea
2015
Nutrasource
2015
New Generation University College
2013
Transcriptional profiling and transcription factor matching reveal potential targets for therapies against diseases associated with mitochondrial dysfunction.
Here, we demonstrate that SENP2, a desumoylating enzyme, plays critical role in the control of adipogenesis. SENP2 expression was markedly increased upon induction adipocyte differentiation, and this increase dependent on protein kinase A activation. Remarkably, knockdown led to dramatic attenuation adipogenesis with marked decrease PPARgamma C/EBPalpha mRNA levels. Knockdown also caused reduction level C/EBPbeta but not mRNA. Interestingly, sumoylation dramatically its ubiquitination...
Intramuscular lipid accumulation is a common manifestation of chronic caloric excess and obesity that strongly associated with insulin resistance. The mechanistic links between in myocytes resistance are not completely understood. In this work, we used high-throughput chemical biology screen to identify small-molecule probe, SBI-477, coordinately inhibited triacylglyceride (TAG) synthesis enhanced basal glucose uptake human skeletal myocytes. We then determined SBI-477 stimulated signaling...
Small ubiquitin-like modifier (SUMO)-specific proteases (SENPs) that reverse protein modification by SUMO are involved in the control of numerous cellular processes, including transcription, cell division, and cancer development. However, physiological function SENPs energy metabolism remains unclear. Here, we investigated role SENP2 fatty acid C2C12 myotubes vivo. In myotubes, treatment with saturated acids, like palmitate, led to nuclear factor-κB–mediated increase expression SENP2. This...
Background Recently, it has been suggested that enhancement of incretin effect improves cardiac function. We investigated the a DPP-IV inhibitor, des-fluoro-sitagliptin, in reducing occurrence restenosis carotid artery response to balloon injury and related mechanisms. Methods Findings Otsuka Long-Evans Tokushima Fatty rats were grouped into four: control (normal saline) sitagliptin 100, 250 500 mg/kg per day (n = 10 group). Sitagliptin or normal saline given orally from 1 week before 2...
Activation of the Wnt/β‐catenin signaling pathway inhibits adipogenesis, while disruption Wnt leads to spontaneous adipogenesis. CCAAT/enhancer binding protein β (C/EBPβ) is rapidly induced in early stages adipogenesis and responsible for transcriptional induction two major adipogenic transcription factors, peroxisome proliferator‐activated receptor γ (PPARγ) C/EBPα. In this study, we examined whether C/EBPβ involved suppression during Knockdown expression not only inhibited but also...
The number of diabetic patients worldwide is increasing, and complications such as stroke cardiovascular disease are becoming a serious cause death. Diabetes mellitus classified into two types according to the etiopathogenic mechanism insulin dependence. Type 1 diabetes (T1D), an insulin-dependent mellitus, caused by damage destruction pancreatic β cells that produce insulin. It characterized hyperglycemia hypoinsulinemia. Aronia berry has been used medicinal food in Europe. contains variety...
The pathogenesis of type 2 diabetes mellitus (T2DM) is closely associated with mitochondrial functions in insulin-responsive tissues. proteome, compared the genome, which only contains 37 genes humans, can provide more comprehensive information for thousands proteins regarding T2DM-associated functions. However, protein signatures tissues are still unclear. Here, we performed extensive proteome profiling mitochondria from skeletal muscles nine T2DM patients and nondiabetic controls. A...
Obesity-related insulin resistance is associated with intramyocellular lipid accumulation in skeletal muscle. We hypothesized that contrast to current dogma, this linkage related an upstream mechanism coordinately regulates both processes. demonstrate the muscle-enriched transcription factor MondoA glucose/fructose responsive human myotubes and directs of genes cellular metabolic pathways involved diversion energy substrate from a catabolic fate into nutrient storage including fatty acid...
Although KRASG12C inhibitors have shown promising activity in lung adenocarcinomas harbouring KRASG12C, acquired resistance to these therapies eventually occurs most patients. Re-expression of KRAS is thought be one the main causes resistance. However, mechanism through which cancer cells re-express not fully understood. Here, we report that Hedgehog signal induced by and mediates re-expression treated with a inhibitor. Further, formation primary cilia activated Hedgehog-GLI-1 pathway. GLI-1...
Abstract More than half of tumor patients with high PD-L1 expression do not respond to anti-PD-1/PD-L1 therapy, and the underlying mechanisms are yet be clarified. Here we show that developmentally regulated GTP-binding protein 2 (DRG2) is required for response PD-L1-expressing tumors anti-PD-1 therapy. DRG2 depletion enhanced IFN-γ signaling increased level in melanoma cells. However, it inhibited recycling endosomal reduced surface levels, which led defects interaction PD-1. Anti-PD-1 did...
PPAR (peroxisome-proliferator-activated receptor) γ, a nuclear receptor, can be conjugated with SUMO (small ubiquitin-like modifier), which results in the negative regulation of its transcriptional activity. In present study, we tested whether de-SUMOylation PPARγ affects expression target genes mouse muscle cells and investigated mechanism by increases We found that SUMO-specific protease SENP2 [SUMO1/sentrin/SMT3 (suppressor mif two 3 homologue 1)-specific peptidase 2] effectively...
Vitamins K<sub>1</sub>, MK-4 and MK-7 have anti-osteoporotic properties, while their regulation effects on osteoclastogenesis are somewhat different.
The molecular mechanisms underlying the pathogenesis of neurodegenerative diseases such as Alzheimer's disease, Parkinson's disease (PD), and Huntington's remain enigmatic, resulting in an unmet need for therapeutics development. Here, we suggest that filbertone, a key flavor compound found fruits hazel trees genus Corylus, can ameliorate PD via lowering abundance aggregated α-synuclein. We previously reported inhibition hypothalamic inflammation by filbertone is mediated suppression nuclear...
Sulfonylurea primarily stimulates insulin secretion by binding to its receptor on the pancreatic β-cells. Recent studies have suggested that sulfonylureas induce sensitivity through peroxisome proliferator-activated γ (PPARγ), one of nuclear receptors. In this study, we investigated effects sulfonylurea PPARγ transcriptional activity and glucose uptake via PPARγ.Transcription reporter assays using Cos7 cells were performed determine if specific stimulate transactivation. Glimepiride,...
Thiazolidinediones (TZDs) are synthetic ligands of peroxisome proliferator-activated receptor-γ (PPARγ), a member the nuclear receptor superfamily. TZDs known to increase insulin sensitivity and also have an antioxidative effect. In this study, we tested whether protect pancreatic β-cells from oxidative stress, investigated mechanism involved in process. To generate stress (INS-1 βTC3) or isolated islets, glucose oxidase was added media. The extracellular intracellular reactive oxygen...