A5023731170- Spine and Intervertebral Disc Pathology
- Spinal Fractures and Fixation Techniques
- Medical Imaging and Analysis
- Adipose Tissue and Metabolism
- Pancreatic function and diabetes
- Scoliosis diagnosis and treatment
- Peroxisome Proliferator-Activated Receptors
- Ubiquitin and proteasome pathways
- Musculoskeletal pain and rehabilitation
- Metabolism, Diabetes, and Cancer
- Bone Tissue Engineering Materials
- Cervical and Thoracic Myelopathy
- Orthopaedic implants and arthroplasty
- Adipokines, Inflammation, and Metabolic Diseases
- Pelvic and Acetabular Injuries
- Dental Implant Techniques and Outcomes
- Shoulder Injury and Treatment
- Cancer, Hypoxia, and Metabolism
- Lipid metabolism and biosynthesis
- Autophagy in Disease and Therapy
- Diabetes and associated disorders
- Cannabis and Cannabinoid Research
- Immunotherapy and Immune Responses
- Radiation Effects in Electronics
- Peptidase Inhibition and Analysis
Seoul National University Hospital
2014-2025
Bumin Hospital Group
2021-2024
Seoul National University
2010-2019
Sungkyunkwan University
2006-2018
Samsung Medical Center
2005-2018
New Generation University College
2013-2018
Biomedical Research Institute
2013-2018
Zero to Three
2011
Wonkwang University
2010
Kyungpook National University
2006
Oxidative stress plays an important role in the pathogenesis of insulin resistance and type 2 diabetes mellitus diabetic vascular complications.Thiazolidinediones (TZDs), a class peroxisome proliferatoractivated receptor ␥ (PPAR␥) agonists, improve sensitivity are currently used for treatment mellitus.Here, we show that TZD prevents oxidative stress-induced human skeletal muscle cells, as indicated by increase insulin-stimulated glucose uptake signaling.Importantly, TZD-mediated activation...
Radiological analysis and classification of normal patterns sagittal alignment the spine.To classify spine in young asymptomatic adults analyze differences various spinal pelvic parameters according to these patterns.Previous studies reported that overall pattern balance were more important than normative values. There are few on white populations, classifying curvature, no Asian populations.Whole spine, standing lateral radiographs 86 Korean volunteers taken. The (total thoracic kyphosis,...
Here, we demonstrate that SENP2, a desumoylating enzyme, plays critical role in the control of adipogenesis. SENP2 expression was markedly increased upon induction adipocyte differentiation, and this increase dependent on protein kinase A activation. Remarkably, knockdown led to dramatic attenuation adipogenesis with marked decrease PPARgamma C/EBPalpha mRNA levels. Knockdown also caused reduction level C/EBPbeta but not mRNA. Interestingly, sumoylation dramatically its ubiquitination...
Impaired revascularization of transplanted islets is a critical problem that leads to progressive islet loss. Since endothelial progenitor cells (EPCs) are known aid neovascularization, we aimed enhance engraftment by cotransplanting EPCs with islets. Porcine islets, (islet-EPC group) or without (islet-only human cord blood–derived EPCs, were into diabetic nude mice. The islet-EPC group reached euglycemia ∼11 days posttransplantation, whereas the islet-only did not. Also, had higher serum...
Small ubiquitin-like modifier (SUMO)-specific proteases (SENPs) that reverse protein modification by SUMO are involved in the control of numerous cellular processes, including transcription, cell division, and cancer development. However, physiological function SENPs energy metabolism remains unclear. Here, we investigated role SENP2 fatty acid C2C12 myotubes vivo. In myotubes, treatment with saturated acids, like palmitate, led to nuclear factor-κB–mediated increase expression SENP2. This...
There has been much controversy, in the surgical treatment of idiopathic thoracolumbar and lumbar scoliosis, about whether anterior or posterior instrumentation produced a better result. This study compared Zielke ventral derotation system (VDS) Cotrel-Dubousset (CDI) correction frontal, sagittal, roattional deformity, defined advantage disadvantage each instrument scoliosis. The was used 20 patients (VDS group) (CDI group). average age VDS group at time surgery 16.7 years, that CDI 18.5...
Activation of the Wnt/β‐catenin signaling pathway inhibits adipogenesis, while disruption Wnt leads to spontaneous adipogenesis. CCAAT/enhancer binding protein β (C/EBPβ) is rapidly induced in early stages adipogenesis and responsible for transcriptional induction two major adipogenic transcription factors, peroxisome proliferator‐activated receptor γ (PPARγ) C/EBPα. In this study, we examined whether C/EBPβ involved suppression during Knockdown expression not only inhibited but also...
Abnormally high levels of circulating free fatty acids can lead to pancreatic islet β-cell dysfunction and apoptosis, contributing failure in Type 2 diabetes. The NAD+-dependent protein deacetylase Sirtuin-3 (SIRT3) has been implicated In this study, we tested whether SIRT3 overexpression affects palmitate-induced cells line NIT1, which are derived from mouse β-cells. Two different lengths were overexpressed: full length (SIRT3LF), was preferentially targeted mitochondria partially the...
Abstract Retinol-binding protein 4 (RBP4), the sole specific carrier for retinol (vitamin A) in circulation, is highly expressed liver and adipose tissues. Previous studies have demonstrated that RBP4 plays a role cold-mediated tissue browning thermogenesis. However, of brown its metabolic significance remain unclear. Here we generated studied transgenic mice express human (hRBP4), specifically adipocytes (UCP1-RBP4 mice), to better understand these uncertainties. When fed chow diet,...
A lumbar total disc replacement (TDR) is believed to be a promising substitute in the surgical treatment for degenerative disease. The purpose of this study report clinical and radiographic outcomes 36 consecutive patients who underwent TDR using ProDisc II, factors associated with better outcome after 2-year minimum follow-up. At time latest follow-up, success rate was 94% according criteria US Food Drug Administration. Of 10 unable work preoperatively, 7 returned work. Moreover, mean score...
There is still debate as to whether antiatherosclerotic effect of PPARgamma ligands dependant on gene itself or some other pathway.To investigate the modulation neointima formation after balloon injury, we delivered adenoviral vectors expressing wild-type (WT) dominant negative (DN) PPARgamma, a control (beta-galactosidase [BG]) into carotid artery injury in rosiglitazone (a ligand)-treated (R+) (3 mg/kg/d) and nontreated (R-) rats. Two weeks delivery, both R+ R- animals, PPARgamma-WT...
A retrospective study.To determine the critical length of fusion that warrants additional stronger fixation in lumbosacral (L-S) fusion, and to analyze risk factors nonunion at L-S junction.Long lever arm down S1 requires than short fusion. However, no published criteria are available about requiring ilium or S2 obtain adequate stability for union junction.A total 327 adult patients with degenerative lumbar disease, who were treated instrumented including junction, included this study. Mean...
Increasing evidence has shown that small ubiquitin-like modifier (SUMO) modification plays an important role in metabolic regulation. We previously demonstrated SUMO-specific protease 2 (SENP2) is involved lipid metabolism skeletal muscle and adipogenesis. In this study, we investigated the function of SENP2 pancreatic β cells by generating a cell-specific knockout (Senp2-βKO) mouse model. Glucose tolerance insulin secretion were significantly impaired Senp2-βKO mice. addition,...