A5018992162- Metabolism, Diabetes, and Cancer
- Endodontics and Root Canal Treatments
- Diet, Metabolism, and Disease
- Adipose Tissue and Metabolism
- Natural Antidiabetic Agents Studies
- Carbohydrate Chemistry and Synthesis
- Pancreatic function and diabetes
- Liver Disease Diagnosis and Treatment
- Dental materials and restorations
- Synthesis of Organic Compounds
- Receptor Mechanisms and Signaling
- PI3K/AKT/mTOR signaling in cancer
- Biochemical and Molecular Research
- Alcohol Consumption and Health Effects
- Muscle metabolism and nutrition
- Protein Kinase Regulation and GTPase Signaling
- Calcium signaling and nucleotide metabolism
- Immunotherapy and Immune Responses
- Dental Anxiety and Anesthesia Techniques
- Glycosylation and Glycoproteins Research
- Click Chemistry and Applications
- Enzyme Catalysis and Immobilization
- Dental Erosion and Treatment
- Bioactive natural compounds
- Immune Cell Function and Interaction
Purdue University West Lafayette
2025
University of Pennsylvania
2019-2024
Friedrich Schiller University Jena
2023-2024
Jena University Hospital
2023-2024
Institute of Molecular Biotechnology
2023-2024
Center for Clinical Studies
2023
Central Drug Research Institute
2009-2021
University of California, Irvine
2018-2019
Kothiwal Dental College and Research Centre
2016-2018
University of Lucknow
2016
Glucagon-like peptide 1 (GLP-1) receptor agonists reduce food intake, producing remarkable weight loss in overweight and obese individuals. While much of this is fat mass, there also a lean similar to other approaches that induce calorie deficit. Targeting signaling pathways regulate skeletal muscle hypertrophy promising avenue preserve mass modulate body composition. Myostatin Activin A are TGFβ-like ligands signal via the activin type II receptors (ActRII) antagonize growth. Pre-clinical...
Skeletal muscle insulin signaling is a major determinant of growth and glucose homeostasis. Protein kinase B/Akt plays prominent role in mediating many the metabolic effects insulin. Mice humans harboring systemic loss-of-function mutations Akt2, most abundant Akt isoform tissues, are intolerant resistant. Since skeletal accounts for significant amount postprandial disposal, popular hypothesis diabetes field suggests that reduction Akt, specifically muscle, leads to intolerance resistance....
Long term successful root canal treatment requires effective debridement and disinfection of system. Persistent periradicular lesions are usually associated with Enterococccus faecalis. Prompt research for natural alternatives irrigation is mainly due to the constant increase in antibiotic resistant strains side effects caused by synthetic drugs. Sodium hypochlorite; gold standard has many disadvantages. Therefore, present study was aimed explore newer irrigants probably be as more at same...
Summary Dendritic cells (DCs) are critical antigen-presenting which the initiators and regulators of immune response. Numerous studies support idea that dietary sugars influence DC functions. Increased consumption fructose has been thought to be leading cause metabolic disorders. Although evidence supports their association with dysfunction, specific mechanisms not well understood. Fructose is one main in our diet. Therefore, here we compared effect glucose on functions human DCs. High...
The antidiabetic effect of the ethanolic extract Eclipta alba (EEA) on hyperglycaemia and diabetic nephropathy was investigated in streptozotocin-induced rats. Single-dose treatment EEA to rats lowered blood glucose level by 17.6% (p < 0.05) at 250 mg kg(-1) dose after 5 h post oral administration. Treatment animals 10 weeks STZ-treatment with (250 kg(-1)) for 21 days significantly reduced elevated levels glucose, %HbA1C, urea, uric acid creatinine, increased depressed serum insulin level....
Postprandial hyperglycemia is a prominent and early defect in diabetes regulating blood glucose elevation may attenuate progression towards associated secondary complications.Here we investigated the alphaglucosidase inhibitory potential of ethanolic extract stem bark Acacia nilotica (EEAN).The EEAN showed remarkable alpha-glucosidase effect with IC 50 value around 8 µg/ml.Kinetic studies revealed that inhibited competitive manner caused conformational changes structure enzyme protein.In...
High fructose consumption has implicated in insulin resistance and metabolic syndrome. Fructose is a highly lipogenic sugar that intense effects liver. Recent evidences suggest exposure to other tissues substantial profound consequences predisposing toward chronic conditions such as type 2 diabetes. Since skeletal muscle the major site for glucose utilization, present study we define of on utilization cells. Upon exposure, L6 cells displayed diminished uptake, transporter 4 (GLUT4)...
The purpose of this study was to compare the antibacterial properties Azadirachta indica (neem) or Curcuma longa (turmeric) against Enterococcus faecalis with those 5% sodium hypochlorite 2% chlorhexidine as root canal irrigants in vitro. activity neem, chlorhexidine, hypochlorite, turmeric E. measured on agar plates using diffusion method. tube dilution method used determine minimum inhibitory concentration (MIC) and bactericidal (MBC) used. Chlorhexidine neem exhibited greatest when...
Obesity-related insulin resistance is associated with intramyocellular lipid accumulation in skeletal muscle. We hypothesized that contrast to current dogma, this linkage related an upstream mechanism coordinately regulates both processes. demonstrate the muscle-enriched transcription factor MondoA glucose/fructose responsive human myotubes and directs of genes cellular metabolic pathways involved diversion energy substrate from a catabolic fate into nutrient storage including fatty acid...
<br><b>Introduction:</b> The main objective of adhesive dentistry is to create an effective, durable union between the tooth structure and restorative material. However, degradation dentine interface remains largely responsible for relatively short lifetime colored resin restoration.<br><b>Aim:</b> aim study compare dentin collagen stabilization property Chlorhexidine (CHX) <i>Aloe barbadensis</i> Miller using shear bond strength testing.<br><b>Materials Methods:</b> Occlusal reduction was...
Abstract G protein-coupled receptors (GPCRs) are mainly regulated by GPCR kinase (GRK) phosphorylation and subsequent β-arrestin recruitment. The ubiquitously expressed GRKs classified into cytosolic GRK2/3 membrane-tethered GRK5/6 subfamilies. interact with activated protein βγ-subunits to translocate the membrane. Yet, this need was not linked as a factor for bias, influencing effectiveness of β-arrestin-biased agonist creation. Using multiple approaches such mutants unable Gβγ, inhibitors...