A5032821596- Immunotherapy and Immune Responses
- Immune Cell Function and Interaction
- T-cell and B-cell Immunology
- Immune Response and Inflammation
- Neuroinflammation and Neurodegeneration Mechanisms
- Tryptophan and brain disorders
- Reproductive System and Pregnancy
- Vitamin C and Antioxidants Research
- CAR-T cell therapy research
- COVID-19 Clinical Research Studies
- Cancer-related cognitive impairment studies
- Long-Term Effects of COVID-19
- Antimicrobial Peptides and Activities
- Alzheimer's disease research and treatments
- Vitamin D Research Studies
- SARS-CoV-2 and COVID-19 Research
- Extracellular vesicles in disease
- Monoclonal and Polyclonal Antibodies Research
- Prostate Cancer Treatment and Research
- Cytomegalovirus and herpesvirus research
- Immune responses and vaccinations
- Vitamin K Research Studies
- Cancer Immunotherapy and Biomarkers
- Venous Thromboembolism Diagnosis and Management
- IL-33, ST2, and ILC Pathways
University of California, Irvine
2016-2025
Datta Meghe Institute of Medical Sciences
2020-2024
Moscow Institute of Thermal Technology
2024
Mansoura University
2023
Queen's University
2023
Emory University
2004-2022
UC Irvine Health
2018-2020
Irvine University
2020
University of California System
2010-2020
Irvine Valley College
2020
Dendritic cells (DCs) are pivotal in determining the class of an adaptive immune response. However, molecular mechanisms within DCs that determine this decision-making process unknown. Here, we demonstrate distinct Toll-like receptor (TLR) ligands instruct human to induce Th cell responses by differentially modulating mitogen-activated protein kinase signaling. Thus, Escherichia coli LPS and flagellin, which trigger TLR4 TLR5, respectively, stimulate Th1 via IL-12p70 production, depends on...
Abstract The adaptive immune system can generate distinct classes of responses, but the mechanisms that determine this are poorly understood. In study, we demonstrate different Toll-like receptor (TLR) ligands induce dendritic cell (DC) activation and responses in vivo. Thus, Escherichia coli LPS (TLR-4 stimulus), activates DCs to produce abundant IL-12(p70), little IL-10, stimulates Th1 Tc1 responses. contrast, Pam-3-cys (TLR-2 stimulus) elicits less favors Th2 T cytotoxic 2 (Tc2) These...
Abstract Aging represents a state of paradox where chronic inflammation is associated with declining immune responses. Dendritic cells (DCs) are the major APCs responsible for initiating an response. However, DC functions in aging have not been studied detail. In this study, we compared innate monocyte-derived myeloid DCs from elderly subjects young individuals. We show that although phenotypically comparable, functionally different young. contrast to young, individuals display 1)...
Summary Muscle stem (satellite) cells are relatively resistant to cell‐autonomous aging. Instead, their endogenous signaling profile and regenerative capacity is strongly influenced by the aged P‐Smad3, differentiated niche, circulation. With respect muscle fibers, we previously established that a shift from active Notch excessive transforming growth factor‐beta (TGF‐β) induces CDK inhibitors in satellite cells, thereby interfering with productive myogenic responses. In contrast, systemic...
Abstract Diminished immune functions and chronic inflammation are hallmarks of aging. The underlying causes not well understood. In this investigation, we show an increased reactivity dendritic cells (DCs) from aged subjects to self-Ags as one the potential mechanisms contributing age-associated inflammation. Consistent with this, DCs display intracellular human DNA, a self-Ag, by secreting enhanced quantities type I IFN IL-6 compared young subjects. Furthermore, is accompanied up-regulation...
Increased susceptibility to infections, particularly respiratory viral is a hallmark of advancing age. The underlying mechanisms are not well understood, and there scarcity information regarding the contribution innate immune system, which first line defense against infections. In present study, we have investigated effect age on plasmacytoid dendritic cell (PDC) function because they critical in generating robust antiviral response via secretion interferons (IFN). Our results indicate that...
Hindawi Publishing Corporation BioMed Research International Volume 2013, Article ID 835105, 2 pages http://dx.doi.org/10.1155/2013/835105 Editorial Novel Vaccine Adjuvants Anshu Agrawal, 1 Mohammad Owais, and Udai P. Singh 3 Division of Basic Clinical Immunology, Department Medicine, University California, Irvine, CA 92697, USA Interdisciplinary Biotechnology Unit, Aligarh Muslim University, Aligarh, Uttar Pradesh 202002, India Pathology, Microbiology South Carolina, School Building 1, Room...
The water-soluble biotin (vitamin B7) is indispensable for normal human health. vitamin acts as a cofactor five carboxylases that are critical fatty acid, glucose, and amino acid metabolism. Biotin deficiency associated with various diseases, mice deficient in this display enhanced inflammation. Previous studies have shown affects the functions of adaptive immune T NK cells, but its effect(s) on innate cells not known. Because because vitamins such A D profound effect dendritic cell (DC)...
Regenerative therapies to mitigate Alzheimer's disease (AD) neuropathology have shown very limited success. In the recent era, extracellular vesicles (EVs) derived from multipotent and pluripotent stem cells considerable promise for treatment of dementia many neurodegenerative conditions.Using 5xFAD accelerated transgenic mouse model AD, we now show regenerative potential human neural cell (hNSC)-derived EVs on neurocognitive neuropathologic hallmarks in AD brain. Two- or 6-month-old mice...
Abstract Activation of MAPK ERK1/2 has been shown to play an important role in Th1/Th2 polarization and regulating cytokine production from APCs. The ERK family consists two members ERK1 ERK2, which share ∼84% identity at the amino acid level can compensate for each other most functions. Despite these features, ERK2 do serve different functions, but there is very little information on contribution individual forms innate adaptive immune responses. In this study, we describe that ERK1−/− mice...
Recent studies have unequivocally identified multipotent stem/progenitor cells in mammary glands, offering a tractable model system to unravel genetic and epigenetic regulation of epithelial cell development homeostasis. In this study, we show that Pygo2, member an evolutionarily conserved family plant homeo domain–containing proteins, is expressed embryonic postnatal progenitor cells. Pygo2 deficiency, which achieved by complete or epithelia-specific gene ablation mice, results defective...
Transcriptional control plays a key role in regulating epidermal proliferation and differentiation. Although ample information has been obtained on how homeostasis is controlled adult skin, less known about the of proliferation/differentiation stem/progenitor cells developing embryo. Ovol1, encoding zinc finger protein homologous to Drosophila melanogaster Ovo, expressed embryonic progenitor that are transiting from terminal In this study, we demonstrate function for Ovol1 interfollicular...
Chronic inflammation, increased reactivity to self-antigens and incidences of cancer are hallmarks aging. However, the underlying mechanisms not well understood. Age-associated alterations in DNA either due oxidative damage, defects repair or epigenetic modifications such as methylation that lead mutations changes expression genes thought be partially responsible. Here we report aged also increase its immunogenicity rendering it more reactive innate immune system cells dendritic cells. We...
Background Dendritic cells capture antigens through PRRs and modulate adaptive immune responses. The type of T cell response generated is dependent upon the PRR activated by microbes. Dectin-1 a C-type lectin receptor present on dendritic cells. Methodology/Principal Findings Here we show that selective dectin-1 agonist Curdlan can activate human DCs induce secretion large amounts IL-23, IL-1β, IL-6 low levels IL-12p70 as determined ELISA. Curdlan-stimulated are efficient at priming naïve...