A5041014714- Herpesvirus Infections and Treatments
- SARS-CoV-2 and COVID-19 Research
- Immune Cell Function and Interaction
- Immunotherapy and Immune Responses
- T-cell and B-cell Immunology
- COVID-19 Clinical Research Studies
- Reproductive System and Pregnancy
- Cytomegalovirus and herpesvirus research
- Immune Response and Inflammation
- Climate Change and Health Impacts
- Global Health Care Issues
- vaccines and immunoinformatics approaches
- Animal Virus Infections Studies
- Global Maternal and Child Health
- Health disparities and outcomes
- Renal Diseases and Glomerulopathies
- interferon and immune responses
- Pregnancy and preeclampsia studies
- Renal and Vascular Pathologies
- Ocular Surface and Contact Lens
- Global Public Health Policies and Epidemiology
- COVID-19 epidemiological studies
- Tuberculosis Research and Epidemiology
- Injury Epidemiology and Prevention
- Adipokines, Inflammation, and Metabolic Diseases
University of California, Irvine
2012-2025
Centennial College
2023
Sanjay Gandhi Post Graduate Institute of Medical Sciences
2012-2022
Institute of Neurosciences Kolkata
2022
Institute for Health Metrics and Evaluation
2018-2020
National Institute of Technology Calicut
2020
UC Irvine Health
2020
Mario Negri Institute for Pharmacological Research
2020
Istituti di Ricovero e Cura a Carattere Scientifico
2020
The Royal Melbourne Hospital
2020
Background The coronavirus disease 2019 (COVID-19) pandemic has created one of the largest global health crises in almost a century. Although current rate Severe acute respiratory syndrome 2 (SARS-CoV-2) infections decreased significantly, long-term outlook COVID-19 remains serious cause morbidity and mortality worldwide, with still substantially surpassing even that recorded for influenza viruses. continued emergence SARS-CoV-2 variants concern (VOCs), including multiple heavily mutated...
Since early 2020, several SARS-CoV-2 variants of concern (VOCs) continue to emerge, evading waning antibody mediated immunity produced by the current Spike-alone based COVID-19 vaccines. This caused a prolonged and persistent pandemic that is going enter its fifth year. Thus, need remains for innovative next generation vaccines would incorporate protective Spike-derived B-cell epitopes resist immune evasion. Towards goal, in this study we (i) Screened sequences Spike among many VOCs...
Abstract Over the last two decades, there have been three deadly human outbreaks of coronaviruses (CoVs) caused by SARS-CoV, MERS-CoV, and SARS-CoV-2, which has current COVID-19 global pandemic. All CoVs originated from bats transmitted to humans via various intermediate animal reservoirs. It remains highly possible that other COVID pandemics will emerge in coming years yet another spillover a bat-derived SARS-like coronavirus (SL-CoV) into humans. Determining Ag B cells, CD4+ CD8+ T cell...
Background Cross-reactive SARS-CoV-2-specific memory CD4 + and CD8 T cells are present in up to 50% of unexposed, pre-pandemic, healthy individuals (UPPHIs). However, the characteristics cross-reactive associated with subsequent protection asymptomatic coronavirus disease 2019 (COVID-19) patients (i.e., unvaccinated who never develop any COVID-19 symptoms despite being infected SARS-CoV-2) remains be fully elucidated. Methods This study compares antigen specificity, frequency, phenotype,...
The crosstalk between the host's inflammasome system and invading virulent/less-virulent viruses determines outcome of ensuing inflammatory response. An appropriate activation inflammasomes triggers antiviral responses that clear virus heal inflamed tissue. However, an aberrant can result in a harmful overwhelming inflammation could damage infected underlying immune mechanisms viral virulent factors impact severe clinical disease remain to be fully elucidated. In this study, we used herpes...
Abstract SARS-CoV-2 variants of concern (VOCs) continue to evolve and reemerge with chronic inflammatory long COVID sequelae, necessitating the development anti-inflammatory therapeutic molecules. Therapeutic effects receptor for advanced glycation end products (RAGE) were reported in many diseases. However, a effect RAGE COVID-19 has not been reported. In present study, we investigated whether how RAGE-Ig fusion protein would have an antiviral system. The protective was determined vivo...
Background: Nucleoside-modified mRNA encapsulated in lipid nanoparticles (LNPs) have emerged as a promising vaccine strategy, especially for COVID-19. While the LNPs protect from degradation and efficiently deliver to antigen-presenting cells, effect of composition on immunogenicity protective efficacy mRNA/LNP vaccines is not well characterized. Studies using platform largely focused nucleic acid cargo with less attention paid LNP vehicle. Whether biophysical properties impact performance...
HSV-specific tissue-resident memory CD8 + T RM cells play a critical role in preventing virus reactivation from latently infected TG and subsequent shedding tears that trigger the recurrent corneal herpetic disease. In this report, we determined how dual blockade of PD-1 LAG-3 immune checkpoints, combined with vaccination, improved function associated significant reduction ocular herpes HLA transgenic (Tg) rabbit model. The appeared to have synergistic effect generating frequent...
Abstract The aim of this study was to investigate the HLA ‐G 14‐bp insertion/deletion (I/D) polymorphism among end‐stage renal disease ( ESRD ) patients. Cytomegalovirus CMV infection, acute allograft rejection AR and overall survival after transplantation investigated in 300 patients 302 age, sex ethnicity‐matched controls. Sequencing performed evaluate impact promoter region single‐nucleotide polymorphisms SNPs whereas semi‐quantitative PCR method used determine probable expression pattern...
Although the current rate of SARS-CoV-2 infections has decreased significantly, COVID-19 still ranks very high as a cause death worldwide. As October 2023, weekly mortality is at 600 deaths in United States alone, which surpasses even worst rates recorded for influenza. Thus, long-term outlook serious concern outlining need next-generation vaccine. This study found that prime/pull coronavirus vaccine strategy increased frequency functional SARS-CoV-2-specific CD4
Abstract Four major mucosal-associated chemokines, CCL25, CCL28, CXCL14, and CXCL17, play an important role in protecting mucosal surfaces from infectious pathogens. However, their protection against genital herpes remains to be fully explored. The CCL28 is a chemoattractant for the CCR10 receptor–expressing immune cells produced homeostatically human vaginal mucosa (VM). In this study, we investigated of CCL28/CCR10 chemokine axis mobilizing protective antiviral B T cell subsets into VM...
ABSTRACT The first-generation Spike-alone-based COVID-19 vaccines have successfully contributed to reducing the risk of hospitalization, serious illness, and death caused by SARS-CoV-2 infections. However, waning immunity induced these failed prevent immune escape many variants concern (VOCs) that emerged from 2020 2024, resulting in a prolonged pandemic. We hypothesize next-generation Coronavirus (CoV) vaccine incorporating highly conserved non-Spike antigens would confer stronger broader...
ABSTRACT Following acute herpes simplex virus type 2 (HSV-2) infection, the undergoes an asymptomatic latent infection of sensory neurons dorsal root ganglia (DRG). Chemical and physical stress cause intermittent reactivation from latently infected DRG recurrent shedding in genital mucosal epithelium causing symptomatic patients. While T cells appear to play a role controlling reducing severity herpes, mechanisms for recruiting these into vaginal mucosa (VM) remain be fully elucidated. The...
Reactivation of herpes simplex virus 2 (HSV-2) from latency causes viral shedding that develops into recurrent genital lesions. The immune mechanisms protection against remain to be fully elucidated. In this preclinical study, we investigated the protective therapeutic efficacy, in guinea pig model herpes, subunit vaccine candidates were based on eight recombinantly expressed HSV-2 envelope and tegument proteins. These protein antigens (Ags) rationally selected for their ability recall strong CD4
To study the prevalence and clinical characteristics of islet antibody-negative (idiopathic) type 1 diabetes mellitus (T1DM) among Indian children adolescents at time diagnosis illness.In a hospital-based cross-sectional study, we studied 110 patients with T1DM aged ≤18 years. This included 61 duration ≤2 weeks (mean ± SD age onset 9.9 4.4 years) 49 2 to 12 weeks. Antibodies against GAD65 (GADA), IA-2 (IA-2A) zinc transporter 8 (ZnT8A), detected by radio-binding assay, were measured in all...