A5015734300- Cancer-related gene regulation
- Wnt/β-catenin signaling in development and cancer
- Epigenetics and DNA Methylation
- Bone Metabolism and Diseases
- Immune Cell Function and Interaction
- Bone health and treatments
- Cytokine Signaling Pathways and Interactions
- Glycosylation and Glycoproteins Research
- T-cell and B-cell Immunology
- Rheumatoid Arthritis Research and Therapies
- Proteoglycans and glycosaminoglycans research
- Osteomyelitis and Bone Disorders Research
- Skin and Cellular Biology Research
- Gastrointestinal disorders and treatments
- Respiratory Support and Mechanisms
- Fibroblast Growth Factor Research
- Chemokine receptors and signaling
- Cancer Cells and Metastasis
- Pancreatic and Hepatic Oncology Research
- Immunotherapy and Immune Responses
- Mitochondrial Function and Pathology
- Cancer and Skin Lesions
- Pancreatitis Pathology and Treatment
- Systemic Lupus Erythematosus Research
- Ubiquitin and proteasome pathways
Shanghai Jiao Tong University
2012-2025
Kao Yuan University
2012
Xiamen University
2005-2010
University of California, Irvine
2009-2010
University of California System
2009
Developmental Studies Center
2009
Recent studies have unequivocally identified multipotent stem/progenitor cells in mammary glands, offering a tractable model system to unravel genetic and epigenetic regulation of epithelial cell development homeostasis. In this study, we show that Pygo2, member an evolutionarily conserved family plant homeo domain–containing proteins, is expressed embryonic postnatal progenitor cells. Pygo2 deficiency, which achieved by complete or epithelia-specific gene ablation mice, results defective...
Cytokeratins are intermediate filament proteins found in most epithelial cells including the mammary epithelium. Specific cytokeratin expression has been to mark different cell lineages and also associate with putative stem/progenitor cells. However, a comparative analysis of cytokaratins during embryonic postnatal development is currently lacking. Moreover, it not clear whether classes exist development. Here, we use double/triple-label immunofluorescence immunohistochemistry systematically...
Resent studies have identified Pygopus as a core component of the β-catenin/T-cell factor (TCF)/lymphoid-enhancing 1 (LEF) transcriptional activation complex required for expression canonical Wg/Wnt target genes in Drosophila. However, biochemical involvement mammalian proteins β-catenin/TCF/LEF gene remains controversial. In this study, we perform series molecular/biochemical experiments to demonstrate that Pygo2 associates with histone-modifying enzymatic complexes, specifically MLL2...
Rationale: Protein arginine methyltransferase 5 (PRMT5) is an oncogene that promotes tumor cell proliferation, invasion and metastasis. However, the underlying mechanisms by which PRMT5 contributes to progression of cervical cancer especially microenvironment remain poorly understood. Methods: expression level was analyzed Q-PCR, western blot, immunohistochemistry, TCGA database. The role in growth observed transplanted models, function T cells vitro co-culture system investigated through...
Summary Paeoniflorin (PF), extracted from the root of Paeonia lactiflora Pall, exhibits anti‐inflammatory properties in several autoimmune diseases. Osteoclast, only somatic cell with bone resorbing capacity, was direct cause destruction rheumatoid arthritis (RA) and its mouse model, collagen‐induced (CIA). The objective this study to estimate effect PF on CIA mice, explore mechanism destruction. We demonstrated that treatment significantly ameliorated through inflammatory response...
Abstract Paeoniflorin (PF) is a monoterpene glycoside and exhibits multiple effects, including anti-inflammation immunoregulation. To date, the effect of PF on sclerosis (MS) has not been investigated. In this study, we investigated in experimental autoimmune encephalomyelitis (EAE), an animal model for MS. After administered with PF, onset clinical symptoms EAE mice were significantly ameliorated, number Th17 cells infiltrated central nervous system (CNS) spleen was also dramatically...
Sin1 or MAPKAP1 is a key component of mTORC2 signaling complex which necessary for AKT phosphorylation at the S473 and T450 sites, also downstream as well. A number splicing variants have been reported that can produce different isoforms due to exon skipping alternative transcription initiation. In this report, we characterized four isoforms, including novel isoform 3' termination 9a, termed Sin1γ. Sin1γ expression be detected in multiple adult mouse tissues, it encodes C-terminal truncated...
Abstract The IL‐7/IL‐7R pathway plays a vital role in the immune system, especially inflammatory response. Monocytes/macrophages (osteoclast precursors) have been recently recognized as important participants osteoclastogenesis of rheumatoid arthritis (RA) patients. Here, we aimed to investigate therapeutic potential RA and determine whether it could restrain osteoclastogenic functions therefore ameliorate RA. Firstly, collagen‐induced (CIA) mice were administered with IL‐7Rα‐target...
Rheumatoid arthritis (RA) is a complex systemic autoimmune disorder that primarily involves joints, further affects the life quality of patients, and has increased mortality. The pathogenesis RA multiple pathways, resulting in some patients showing resistance to existing drugs. Salubrinal small molecule compound recently been shown exert beneficial effects on bone tissue. However, effect not clearly confirmed. Hence, we induced collagen-induced (CIA) DBA/1J mice found treatment decreased...
[Introduction] Branched Chain Amino Acids (BCAAs), including leucine, isoleucine, and valine, modulate mTOR activity that controls protein synthesis cell growth. PP2Cm is a mitochondrial phosphatase regulates the rate limiting step of BCAA degradation. Loss leads to accumulation. [Hypothesis] downregulation by hypertrophic signal impairs catabolism thus hypertrophy response in heart. [Methods Results] High level expressed heart through all development stages. expression was reduced induced...