Tibetans have lived at very high altitudes for thousands of years, and a distinctive suite physiological traits that enable them to tolerate environmental hypoxia. Expanding awareness knowledge the differences in hematology, hypoxia-associated genes, immune system people living different from ethnic groups may provide evidence prevention mountain sickness.Ninety-five Han mid-altitude, ninety-five Tibetan high-altitude ninety-eight were recruited. Red blood cell parameters, cells, contents...

Rationale: Protein arginine methyltransferase 5 (PRMT5) is an oncogene that promotes tumor cell proliferation, invasion and metastasis. However, the underlying mechanisms by which PRMT5 contributes to progression of cervical cancer especially microenvironment remain poorly understood. Methods: expression level was analyzed Q-PCR, western blot, immunohistochemistry, TCGA database. The role in growth observed transplanted models, function T cells vitro co-culture system investigated through...

The objective of this study was to investigate the potential molecular mechanisms ATPase H+ transporting V1 subunit A (ATP6V1A) underlying Alzheimer's disease (AD).Microarray expression data human temporal cortex samples from GSE118553 dataset were profiled screen for differentially expressed genes (DEGs) between AD/control and ATP6V1A-low/high groups. Correlations coexpression modules with AD ATP6V1A assessed by weight gene correlation network analysis (WGCNA). DEGs strongly interacting...

Bacteriophages are viruses that specifically infect target bacteria. Recently, bacteriophages have been considered potential biological control agents for bacterial pathogens due to their host specificity. Pseudomonas syringae pv. actinidiae (Psa) is a reemerging pathogen causes canker of kiwifruit (Actinidia sp.). The economic impact this pest and the development resistance antibiotics copper sprays in Psa other pathovars led investigation alternative management strategies. Phage therapy...

Objective. The inability to intervene in Alzheimer’s disease (AD) forces the search for promising gene-targeted therapies. This study was aimed at exploring molecular signatures and mechanistic pathways improve diagnosis treatment of AD. Methods. Microarray datasets were collected filter differentially expressed genes (DEGs) between AD nondementia controls. Weight gene correlation network analysis (WGCNA) employed analyze coexpression modules with phenotype. A global regulatory established...

Alzheimer’s disease (AD) and Huntington’s (HD) are destructive worldwide diseases. Efforts have been made to elucidate the process of these two diseases, yet pathogenesis remains elusive as it involves a combination multiple factors, including genetic environmental ones. To explore potential role forkhead box O1 (FOXO1) in development AD HD, we identified 1,853 differentially expressed genes (DEGs) from 19,414 background both AD&HD/control FOXO1-low/high groups. Four coexpression modules...

BackgroundThere is an urgent need for the identification of new, clinically useful biomarkers CRC to enhance diagnostic and prognostic capabilities.MethodsWe performed proteomic profiling on serum samples from paired pre- post-operative patients, colorectal polyps patients healthy controls using approach combining magnetic bead-based weak cation exchange matrix-assisted laser desorption ionization-time flight mass spectrometry. We next liquid chromatography-electrospray ionization-tandem...

The inability to halt or even delay the course of Alzheimer’s disease (AD) forces development new molecular signatures and therapeutic strategies. Insulin like growth factor 1 (IGF1) is a promising target for AD treatment, yet exact mechanisms ascribed IGF1 remain elusive. Herein, gene expression profiles 195 samples were analyzed 19,245 background genes generated, among which 4,424 differentially expressed (DEGs) overlapped between AD/control IGF1-low/high groups. Based on such DEGs, seven...

To investigate the molecular function of phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta (PIK3CB) underlying Alzheimer's disease (AD). RNA sequencing data were used to filtrate differentially expressed genes (DEGs) in AD/nondementia control and PIK3CB-low/high groups. An unbiased coexpression network was established evaluate module-trait relationships by using weight gene correlation analysis (WGCNA). Global regulatory constructed predict protein-protein interaction....

The present study investigated the molecular changes and related regulatory mechanisms in response of skeletal muscle to exercise. microarray dataset 'GSE109657' high‑intensity intermittent exercise training (HIIT) was downloaded from Gene Expression Omnibus database. Differentially expressed genes (DEGs) were screened analyzed using weighted gene co‑expression network analysis (WGCNA) identify significant functional co‑expressed modules. Moreover, enrichment performed for DEGs In addition,...

Tuberculosis remains one of the deadliest infectious diseases worldwide. Only 5-15% people infected with Mycobacterium tuberculosis develop active TB disease (ATB), while others remain latently (LTBI) during their lifetime, which has a completely different clinical treatment schedule. However, most current diagnostic methods are based on immune response M. infections and cannot distinguish ATB from LTBIs. Thus, rapid diagnosis or latent serious challenge for clinicians. In this work, test...

Phenotypic plasticity enables individuals to develop different phenotypes in a changing environment and promotes adaptive evolution. Genome-wide association study (GWAS) facilitates the of genetic basis bacterial phenotypes, provides new opportunity for phenotypic research. To investigate relationship between growth genotype bacteria, 41 Staphylococcus aureus strains, including 29 vancomycin-intermediate S. (VISA) were inoculated absence or presence vancomycin 48 h. Growth curves maximum...

Genetic mutations play a crucial role in the development and progression of myelodysplastic syndromes (MDS), impacting immune microenvironment influencing choice treatment regimen, as well efficacy prognosis patients. The objective this study was to examine variations hematological immunological characteristics associated with common gene MDS patients establish foundation for precise MDS.

Oxidative stress is known to be involved in and possibly a key driver of the development numerous chronic diseases, including cancer. It highly desired have capability reliably estimate level intracellular oxidative as it can help identify functional changes disease phenotypes associated with such stress, but problem proves very challenging. We present novel computational model for quantitatively estimating tissues cells based on their transcriptomic data. The consists (i) three sets marker...

Alzheimer's disease (AD) is associated with cell cycle reentry of mature neurons that subsequently undergo degeneration. This study aimed to identify key regulators the and their underlying pathways for developing optimal treatment AD.RNA sequencing data were profiled screen differentially expressed genes in cycle. Correlation created modules AD phenotype was computed by weight gene correlation network analysis (WGCNA). Signature trophic factor receptors determined using Pearson coefficient...

The linear dependence of the logarithm capacity factor (log k‵) on composition aqueous binary mobile phase is examined systematically in reversed-phase liquid chromatography. In discussing physical significance intercept kw) and slope (S), it found that log kw linearly related to S by regression analysis. Simultaneously, nonlinear quantitative relationships between either or structure parameters solutes are derived from chromatographic thermodynamic theory, which involves two-parameter...

Hypoxia exposure is responsible for the high incidence of congenital heart defects (CHDs) in high-altitude areas, which nearly 20 times higher than that low-altitude areas. However, genetic factors involved are rarely reported. Sestrin2 ( SESN2 ), a hypoxia stress-inducible gene, protects cardiomyocyte viability under stress; thus, polymorphism may be potential risk factor CHD. We performed an association study polymorphisms with CHD two independent groups Han Chinese population from...

Objective. To determine the risks of induced term delivery to mother and neonate at different gestational ages in absence obstetric indications. Study Design. All deliveries New South Wales (NSW) between 1998 2008 were reviewed from MDC. Uncomplicated pregnancies which for non-obstetric reasons after 37 completed weeks reviewed. This was a retrospective, historical cohort study, both maternal neonatal outcomes analysed compared age groups. Results. An analysis data shows that induction...