A5081966055- Advanced X-ray Imaging Techniques
- Advanced X-ray and CT Imaging
- Medical Imaging Techniques and Applications
- Wnt/β-catenin signaling in development and cancer
- Laser-Plasma Interactions and Diagnostics
- Cancer, Stress, Anesthesia, and Immune Response
- Cancer-related molecular mechanisms research
- Developmental Biology and Gene Regulation
- Axon Guidance and Neuronal Signaling
- Hippo pathway signaling and YAP/TAZ
- Ginseng Biological Effects and Applications
- MicroRNA in disease regulation
- Digital Holography and Microscopy
- Target Tracking and Data Fusion in Sensor Networks
- Redox biology and oxidative stress
- Glioma Diagnosis and Treatment
- Antioxidant Activity and Oxidative Stress
- EEG and Brain-Computer Interfaces
- Cancer Cells and Metastasis
- Ferroptosis and cancer prognosis
- Adaptive optics and wavefront sensing
- Wound Healing and Treatments
- Blind Source Separation Techniques
- Machine Learning in Bioinformatics
- GNSS positioning and interference
Changchun University of Chinese Medicine
2024-2025
Jilin University
2010-2023
Union Hospital
2020-2023
Jilin Province Science and Technology Department
2022
Tsinghua University
2015-2020
Beihang University
2012-2014
Deep learning (DL) has shown explosive growth in its application to bioinformatics and demonstrated thrillingly promising power mine the complex relationship hidden large-scale biological biomedical data.A number of comprehensive reviews have been published on such applications, ranging from high-level with future perspectives those mainly serving as tutorials.These provided an excellent introduction guideline for applications DL bioinformatics, covering multiple types machine (ML) problems,...
Ginsenoside Rd is a tetracyclic triterpenoid derivative, widely existing in
Non-small cell lung cancer (NSCLC) is a malignant tumor with high morbidity and mortality. Ginsenosides have been shown to strong antitumor activity, inhibiting growth promoting apoptosis. In this paper, the effects of ginsenoside CK on proliferation apoptosis NSCLC 95D NCI-H460 cells were investigated by CCK8, colony formation assay, flow cytometry, fluorescence staining Western Blot, it was found that could significantly inhibit non-small cancer, also clarified mechanism its action...
Iterative reconstruction has a wide spectrum of proven advantages in the field conventional X-ray absorption-based computed tomography (CT). In this paper, we report on an algebraic iterative technique for grating-based differential phase-contrast CT (DPC-CT). Due to nature DPC-CT projections, operator and smoothing are added reconstruction, compared one commonly used data. This work comprises numerical study algorithm its experimental verification using dataset measured at two-grating...
Abstract Triple negative breast cancer (TNBC) represents the most malignant subtype of cancer, and yet our understanding about its unique biology remains elusive. We have conducted a comparative computational analysis transcriptomic data TNBC non-TNBC (NTNBC) tissue samples from TCGA database, focused on genes involved in neural functions. Our main discoveries are: (1) while both subtypes involve functions, has substantially more up-regulated than NTNBC, suggesting that is complex NTNBC; (2)...
Most existing differential phase-contrast computed tomography (DPC-CT) approaches are based on three kinds of scanning geometries, described by parallel-beam, fan-beam and cone-beam. Due to the potential compact imaging systems with magnified spatial resolution, cone-beam DPC-CT has attracted significant interest. In this paper, we report a reconstruction method back-projection filtration (BPF) algorithm for DPC-CT. nature phase contrast projections, restrains from differentiation projection...
X-ray phase contrast micro computed tomography (micro-CT) can non-destructively provide the internal structure information of soft tissues and low atomic number materials. It has become an invaluable analysis tool for biomedical specimens. Here in
Oxidative stress is known to be involved in and possibly a key driver of the development numerous chronic diseases, including cancer. It highly desired have capability reliably estimate level intracellular oxidative as it can help identify functional changes disease phenotypes associated with such stress, but problem proves very challenging. We present novel computational model for quantitatively estimating tissues cells based on their transcriptomic data. The consists (i) three sets marker...
Mix/Bix genes are important regulators of mesendoderm formation during vertebrate embryogenesis. Sebox, an additional member this gene family, has been implicated in endoderm early embryogenesis zebrafish. However, it remains unclear whether Sebox plays a unique role Xenopus embryos.In study, we provide evidence that is uniquely required for the mesoderm dynamically expressed involuted gastrulation. It activated by Nodal/Activin signaling and modulated zygotic Wnt/β-catenin signaling....
Data from the SEER reports reveal that occurrence rate of a cancer type generally follows unimodal distribution over age, peaking at an age is cancer-type specific and ranges 30+ through 70+. Previous studies attribute such bell-shaped distributions to reduced proliferative potential in senior years but fail explain why some cancers have their peak or 40+. We present computational model offer new explanation distributions. The uses two factors observed age-dependent rates: risk organ...
Recent studies have revealed that neural functions are involved in possibly every aspect of a cancer development, serving as bridges connecting microenvironmental stressors, activities intracellular subsystems, and cell survival. Elucidation the functional roles played by system could provide missing links developing systems-level understanding biology. However, existing information is highly fragmented scattered across literature internet databases, making it difficult for researchers to...
In order to explore the possibility of using bacterial cellulose (BC) as scaffold in tissue engineering, fibroblasts (FB) were cultured seed cells on hydrated membrane (BC). First, FBs isolated by dispase-collagenase system from dermis back skin newborn (within 24 hours) rats and adherently DMEM medium with calf serum (10%) under 5% CO2 37°C at a density 1.0×105 cell/ml. The growth curve was determined MTT method. Second, subcultured rat inoculated BC scaffold, 3.0×10 <sup...
Brain metastasis of a cancer is malignant disease with high mortality, but the cause and molecular mechanism remain largely unknown. Using samples primary tumors 22 types in TCGA database, we have performed computational study their transcriptomic data to investigate drivers brain metastases at basic physics chemistry level. Our main discoveries are: (i) physical characteristics, namely electric charge, weight, hydrophobicity extracellular structures expressed transmembrane proteins affect...