A5068706792- Advanced X-ray Imaging Techniques
- Advanced X-ray and CT Imaging
- Medical Imaging Techniques and Applications
- X-ray Spectroscopy and Fluorescence Analysis
- Advanced MRI Techniques and Applications
- Advanced Electron Microscopy Techniques and Applications
- Radiation Dose and Imaging
- Wireless Networks and Protocols
- Digital Holography and Microscopy
- Nuclear Physics and Applications
- Crystallography and Radiation Phenomena
- Laser-Plasma Interactions and Diagnostics
- Power Line Communications and Noise
- Photoacoustic and Ultrasonic Imaging
- Advanced Wireless Network Optimization
- Digital Radiography and Breast Imaging
- Calibration and Measurement Techniques
- Atomic and Subatomic Physics Research
- Optical measurement and interference techniques
- Infrared Thermography in Medicine
- Advanced Radiotherapy Techniques
- Mobile Ad Hoc Networks
- Cell Image Analysis Techniques
- Radiomics and Machine Learning in Medical Imaging
- Seismic Imaging and Inversion Techniques
Technical University of Munich
2016-2025
University Hospital Regensburg
2025
Bayer (Germany)
2024
Ludwig-Maximilians-Universität München
2011-2022
Klinikum rechts der Isar
2016-2022
Karlsruhe Institute of Technology
2022
Philips (Germany)
2022
NXP (Netherlands)
2022
Philips (Netherlands)
2022
Swisscom (Switzerland)
2016
Although advanced medical imaging technologies give detailed diagnostic information, a low-dose, fast, and inexpensive option for early detection of respiratory diseases follow-ups is still lacking. The novel method x-ray dark-field chest might fill this gap but has not yet been studied in living humans. Enabling the assessment microstructural changes lung parenchyma, technique presents more sensitive alternative to conventional x-rays, requires only fraction dose applied CT. We application...
In early stages of various pulmonary diseases, such as emphysema and fibrosis, the change in X-ray attenuation is not detectable with absorption-based radiography. To monitor morphological changes that alveoli network undergoes progression these we propose using dark-field signal, which related to small-angle scattering sample. Combined image, signal enables better discrimination between healthy emphysematous lung tissue a mouse model. All measurements have been performed at 36 keV...
Purpose To investigate the feasibility of using spectral photon-counting computed tomography (CT) to differentiate between gadolinium-based and nonionic iodine-based contrast material in a colon phantom by characteristic k edge gadolinium. Materials Methods A custom-made was filled with material, gadolinium-filled capsule representing material-enhanced polyp positioned on wall. The scanned preclinical CT system obtain conventional data. By fully multibin information, decomposition performed...
Significance Three-dimensional histology of soft-tissue samples has proven to provide crucial benefits for the understanding tissue structure. Nevertheless, low attenuation soft impaired use computed tomography (CT) as a tool nondestructive and 3D visualization external internal structural details. We present cytoplasm-specific staining method tailored X-ray CT that enables routine efficient volume screening at high resolutions. Our technique is fully compatible with conventional allows...
Abstract X-ray chest radiography is an inexpensive and broadly available tool for initial assessment of the lung in clinical routine, but typically lacks diagnostic sensitivity detection pulmonary diseases their early stages. Recent dark-field (XDF) imaging studies on mice have shown significant improvements imaging-based diagnostics. Especially case diagnosis chronic obstructive disease (COPD), XDF clearly outperforms conventional radiography. However, a translation this technique towards...
Disorders of the lungs such as chronic obstructive pulmonary disease (COPD) are a major cause morbidity and mortality third leading death in world. The absence sensitive diagnostic tests for early stages COPD results under-diagnosis this treatable an estimated 60–85% patients. In recent years grating-based approach to X-ray dark-field contrast imaging has shown be very detection quantification emphysema small animal models. However, translation technique systems suitable humans remains...
In this paper we present the results of a dosimetric evaluation 2D ionization chamber array with objective its implementation for quality assurance in clinical routine. The pixel MatriXX (Scanditronix Wellhofer, Germany) consists 32x32 chambers distance 7.6 mm between centres. effective depth measurement under surface detector was determined. dose and energy dependence, behaviour device during initial phase time stability as well lateral response single cross-plane diagonal directions were...
Over the last few years, differential phase-contrast x-ray computed tomography (PC-CT) using a hard grating interferometer and polychromatic tube sources has been developed. The method allows for simultaneous determination of attenuation coefficient refractive index decrement distribution inside an object in three dimensions. Here we report experimental results our investigation on quantitativeness accuracy this method. For study, phantom consisting several tubes filled with chemically...
SUMMARY Sponges constitute one of the two metazoan phyla that are able to contract their bodies despite a complete lack muscle cells. Two competing hypotheses on mechanisms behind this have been postulated date: (1) mesohyl-mediated contraction originating from fusiform smooth muscle-like actinocytes (‘myocytes’) and (2) epidermal in pinacocytes. No direct support exists for either hypothesis. The question agonist–antagonist interaction sponge seems completely neglected so far. In present...
We report on an experimental characterization of the spatial resolution a commercial X-ray micro-computed tomography scanner. have measured full modulation transfer function (MTF) to assess resolution. The MTF and those frequencies corresponding contrast loss 50% were determined as different applied tube parameters magnification-dependent pixel sizes. A significant influence focal spot enlargement achievable could be shown. Our results allow for designation optimal specific application requirement.
Accounting for about 1.5 million deaths annually, lung cancer is the prevailing cause of worldwide, mostly associated with long-term smoking effects. Numerous small-animal studies are performed currently in order to better understand pathogenesis disease and develop treatment strategies. Within this letter, we propose exploit X-ray dark-field imaging as a novel diagnostic tool detection on projection radiographs. Here, demonstrate living mice bearing tumors, that radiography provides...
The Ediacaran fossil Corumbella is important because it hypothesized to be a scyphozoan cnidarian, and thus might one of the rare examples bona fide Neoproterozoic animals. Unfortunately, its mode life, style skeletonization, taxonomic affinity have been very controversial. Here, we use X-ray micro-CT, SEM, taphonomic analysis compare preservational modes Corumbella, in order better understand symmetry, construction, style, taxonomy this group. Results suggest that articulated disarticulated...
X-ray phase-contrast imaging has received growing interest in recent years due to its high capability visualizing soft tissue. Breast became the focus of particular attention as it is considered most promising candidate for a first clinical application this contrast modality. In study, we investigate quantitative breast tissue characterization using grating-based computed tomography (CT) at conventional polychromatic x-ray sources. Different specimens have been scanned laboratory setup and...
Purpose To evaluate the potential of phase-contrast computed tomography (CT) for atherosclerotic plaque imaging in human carotid arteries an experimental ex vivo study. Materials and Methods The study was approved by institutional review board, informed consent obtained from patients' relatives. Seven postmortem artery specimens were imaged at a laboratory setup using conventional x-ray tube grating interferometer. After histologic processing, histopathologic data matched. Characteristics...
Abstract The possibility to perform high-sensitivity X-ray phase-contrast imaging with laboratory grating-based computed tomography (gbPC-CT) setups is of great interest for a broad range high-resolution biomedical applications. However, achieving high sensitivity gbPC-CT still poses challenge because several factors such as the reduced flux, polychromaticity spectrum and limited coherence source reduce performance in comparison at synchrotron facilities. In this work, we present our...
Abstract The performance of a recently introduced spectral computed tomography system based on dual‐layer detector has been investigated. A semi‐anthropomorphic abdomen phantom for CT evaluation was imaged the at different radiation exposure levels ( CTDI vol 10 mG y, 20 y and 30 y). equipped with specific low‐contrast tissue‐equivalent inserts including water‐, adipose‐, muscle‐, liver‐, bone‐like materials variation in iodine concentrations. Additionally, size varied using extension rings...
To assess the feasibility of dual-contrast spectral photon-counting computed tomography (SPCCT) for liver imaging.We present an SPCCT in-silico study simultaneous mapping complementary distribution in two contrast agents (CAs) subsequently intravenously injected: a gadolinium-based agent and iodine-based agent. Four types simulated lesions with characteristic arterial portal venous pattern (haemangioma, hepatocellular carcinoma, cyst, metastasis) are presented. A material decomposition was...
Achieving precise control in laser-based powder bed fusion of polymers is crucial for ensuring the structural integrity aerospace and automotive components. Closed-loop feedback systems using process monitoring techniques, such as infrared thermography, have potential to provide reliable production by controlling temperature melt. However, challenges arise from complex interactions among variables, part geometry, scan strategy, laser parameters, affecting melted polymer's temperatures...
Abstract Background A significant proportion of false positive recalls mammography‐screened women is due to benign breast cysts and simple fibroadenomas. These lesions appear mammographically as smooth‐shaped dense masses require the recalling for a ultrasound obtain complementary imaging information. They can be identified safely by with no need further assessment or treatment. Purpose Grating‐based x‐ray dark‐field allows contrast formation based on both attenuation small‐angle scattering...
Phase-contrast micro-tomography ([Formula: see text]CT) with synchrotron radiation can aid in the differentiation of subtle density variations weakly absorbing soft tissue specimens. Modulation-based imaging (MBI) extracts phase information from distortion reference patterns, generated by periodic or randomly structured wavefront markers (e.g., gratings sandpaper). The two approaches have already found application for virtual inspection biological samples. Here, we perform high-resolution...
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The dark-field signal obtained with X-ray grating interferometry combines the object's small-angle scattering auto-correlation function an imaging modality. Here we report on measurement of such correlation functions a laboratory system. By fitting theoretical model to data are able determine size and short-range order structures. Thus, quantitative interpretation is also possible polychromatic divergent beam. We further show how microscopic information for mesoscale objects can be...
The imaging beamline (IBL/P05) operated by Helmholtz Zentrum Geesthacht (HZG) at the DESY PETRA III storage ring consists of two experimental stations: A micro tomography and a nano end station. Here an overview setups data acquisition will be given. In addition some first results out wide range applications using station P05 shown. Furthermore, we present These were obtained with x–ray microscopy setup, which currently operates energies 17.4 30 keV polymer compound refractive lenses (CRLs)...