A5077937143- Advanced X-ray and CT Imaging
- Radiation Dose and Imaging
- Medical Imaging Techniques and Applications
- Multiple Sclerosis Research Studies
- Advanced MRI Techniques and Applications
- Heat shock proteins research
- Acute Ischemic Stroke Management
- Peripheral Neuropathies and Disorders
- Pharmacological Effects of Natural Compounds
- Advanced Neuroimaging Techniques and Applications
- Radiomics and Machine Learning in Medical Imaging
- Immune Cell Function and Interaction
- Functional Brain Connectivity Studies
- Long-Term Effects of COVID-19
- Ultrasound Imaging and Elastography
- Ocular Diseases and Behçet’s Syndrome
- Bone and Joint Diseases
- Spine and Intervertebral Disc Pathology
- Dental Radiography and Imaging
- Rheumatoid Arthritis Research and Therapies
- Muscle Physiology and Disorders
- Medical Imaging and Analysis
- Neurobiology of Language and Bilingualism
- Medical Image Segmentation Techniques
- MRI in cancer diagnosis
Technical University of Munich
2016-2025
Klinikum rechts der Isar
2010-2024
Fundação Oswaldo Cruz
2011
Helmholtz Zentrum München
2010
University of Lausanne
2003
Immunization of mice with a 14-mer peptide TKDNNLLGRFELSG, termed “TKD,” comprising amino acids 450–461 (aa ) in the C terminus inducible Hsp70, resulted generation an IgG1 mouse mAb cmHsp70.1. The epitope recognized by cmHsp70.1 mAb, which has been confirmed to be located TKD sequence SPOT analysis, is frequently detectable on cell surface human and tumors, but not isogenic cells normal tissues, membrane Hsp70 might thus serve as tumor-specific target structure. As shown for associated...
Purpose To compare PET/MR hypoperfusion and hypometabolism in patients with Alzheimer disease (AD) mild cognitive impairment (MCI) compared healthy control (HC) participants. Materials Methods Maps of cerebral blood flow (CBF; pulsed arterial spin-labeling [ASL] MRI), glucose metabolism (fluorine 18 [18F] fluorodeoxyglucose [FDG] PET), gray matter (GM) volume (structural T1-weighted MRI) were calculated from integrated data 45 AD (mean age, 69 years ± 9 [standard deviation]; age range, 51-89...
Abstract The performance of a recently introduced spectral computed tomography system based on dual‐layer detector has been investigated. A semi‐anthropomorphic abdomen phantom for CT evaluation was imaged the at different radiation exposure levels ( CTDI vol 10 mG y, 20 y and 30 y). equipped with specific low‐contrast tissue‐equivalent inserts including water‐, adipose‐, muscle‐, liver‐, bone‐like materials variation in iodine concentrations. Additionally, size varied using extension rings...
Abstract Objectives Throughout the pandemic, it has become evident that COVID-19 should be recognized as a systemic disease can affect coagulation system, potentially resulting in arterial thrombotic events (ATE) with partially bulky free-floating clots. This study aimed to investigate incidence and imaging characteristics of ATE hospitalized patients using clinical data. Methods From January 2020 May 2021, databases five German tertiary care centers were retrospectively screened for...
The vast majority of magnetic resonance imaging (MRI) studies on multiple sclerosis (MS) covered the spinal cord (SC), if at all, incompletely. To assess SC involvement in MS, as detectable by whole MRI, with regard to distribution across vertebral levels and relation clinical phenotypes disability. We investigated MRI sagittal axial coverage. Analyzed were brain scans 17 healthy controls (HC) 370 patients either clinically isolated syndrome (CIS, 27), relapsing remitting MS (RRMS, 303) or...
MR imaging plays an important role in diagnosing MS and other related inflammatory diseases; however, of the spinal cord is still challenging. We hypothesized that a 3D double inversion recovery sequence for cervical would be more sensitive detecting lesions than conventional 2D T2-weighted TSE at 3T.On 3T scanner, we examined 30 patients with suspected or established (MS, n = 16; clinically isolated syndrome, 12; myelitis, 2) 10 healthy controls. Newly developed axial sagittal images were...
Functional connectivity of blood oxygenation level dependent signal fluctuations (BOLD-FC) is decreased in Alzheimer’s disease (AD), and suggested to reflect reduced coherence neural population activity; however, as both neuronal vascular-hemodynamic processes underlie BOLD signals, impaired perfusion might also contribute BOLD-FC; 42 AD patients 27 controls underwent simultaneous PET/MR imaging. Resting-state functional MRI assessed co-activity quantify BOLD-FC, pulsed arterial spin...
Objectives To evaluate the accuracy of Spectral Photon-Counting Computed Tomography (SPCCT) in quantification iodine concentrations and its potential for differentiation between blood iodine. Methods Tubes with a concentration series were scanned preclinical SPCCT system (both vitro an ex vivo bovine brain tissue sample). Iodine density maps (IDM) virtual non-contrast (VNC) images generated using multi-bin spectral information to perform material decomposition. Region-of-interest (ROI)...
Abstract The aim was to evaluate the potential of Spectral Photon-Counting Computed Tomography (SPCCT) differentiate between liquid embolic agents and iodinated contrast medium by using tantalum-characteristic K-edge imaging. Tubes with a concentration series tantalum inserts different concentrations iodine were scanned preclinical SPCCT system. Tantalum density maps (TDM) (IDM) generated from acquisition. Furthermore, region-of-interest (ROI) analysis performed within tubes in conventional...
Despite rapid progress in the treatment of many cancers, glioblastoma remains a devastating disease with dismal prognosis. The aim this study was to identify chaperone- and immune-related biomarkers improve prediction outcome glioblastoma. Depending on its intra- or extracellular localization major stress-inducible heat shock protein 70 (Hsp70) fulfills different tasks. In cytosol Hsp70 interferes pro-apoptotic signaling pathways thereby protects tumor cells from programmed cell death....
Spinal cord (SC) lesions have been associated with unfavourable clinical outcomes in multiple sclerosis (MS). However, the relation of whole SC lesion number (SCLN) and volume (SCLV) to future occurrence type confirmed disability accumulation (CDA) remains largely unexplored.
Nowadays, there is no method to quantitatively characterize the material composition of acute ischemic stroke thrombi prior intervention, but dual-energy CT (DE-CT) offers imaging-based multimaterial decomposition. We retrospectively investigated ex vivo using DE-CT with histological analysis as a reference.
Primary progressive aphasia (PPA) is characterized by profound destruction of cortical language areas. Anatomical studies suggest an involvement cholinergic basal forebrain (BF) in PPA syndromes, particularly the area nucleus subputaminalis (NSP). Here we aimed to determine pattern atrophy and structural covariance as a proxy connectivity BF nuclei variants. We studied 62 prospectively recruited cases with clinical diagnosis 31 healthy older control participants from cohort study German...
The aim was to evaluate Virtual Non-Contrast (VNC)-CT images for the detection of acute infarcts in brain after mechanical thrombectomy using a dual-layer spectral CT. 29 patients between September 2016 and February 2017 with unenhanced head spectral-CT available follow-up (MRI, n:26; CT, n:3) were included. VNC-CT conventional CT (CT) reconstructed dedicated software. Based on those, contrast-to-noise ratio (CNR), volume infarction measured semi-automatically VNC-CT, MRI. Furthermore, two...
(1) Background and Purpose: The skeletal muscles of patients suffering from neuromuscular diseases (NMD) are affected by atrophy, hypertrophy, fatty infiltration, edematous changes. Magnetic resonance imaging (MRI) is an important tool for diagnosis monitoring. Concerning T1-weighted or T2-weighted DIXON turbo spin echo (TSE) sequences enable a qualitative assessment muscle involvement. To achieve higher comparability, semi-quantitative grading scales, such as the four-point Mercuri scale,...
Background Data on the frequency and outcome of mechanical thrombectomy (MT) for large vessel occlusion (LVO) in patients with COVID-19 is limited. Addressing this subject, we report our multicenter experience. Methods A retrospective cohort study was performed consecutive acute stroke infection treated MT at 26 tertiary care centers between January 2020 November 2021. Baseline demographics, angiographic clinical evaluated by modified Rankin Scale (mRS) discharge 90 days were noted. Results...
Background Apart from the platelet/endothelial cell adhesion molecule 1 (PECAM-1, CD31), endoglin (CD105) and a positive factor VIII-related antigen staining, human primary immortalized macro- microvascular endothelial cells (ECs) differ in their surface expression of activating inhibitory ligands for natural killer (NK) cells. Here we comparatively study effects irradiation on phenotype ECs interaction with resting activated NK Methodology/Principal Findings Primary macrovascular umbilical...
Progression of glioma is frequently characterized by increases or enhanced spread a hyperintensity in fluid attenuated inversion recovery (FLAIR) sequences. However, changes FLAIR signal over time can be subtle, and conventional (CONV) visual reading time-consuming. The purpose this monocentric, retrospective study was to compare CONV subtraction maps (SMs) for serial imaging. datasets cranial 3-Tesla magnetic resonance imaging (MRI), acquired at two different points (mean inter-scan...
Abstract Background Somatosensory evoked potentials (SSEP) are still broadly used, although not explicitly recommended, for the diagnostic work-up of suspected multiple sclerosis (MS). Objective To relate disability, SSEP, and lesions on T2-weighted magnetic resonance imaging (MRI) in patients with early MS. Methods In this monocentric retrospective study, we analyzed a cohort relapsing–remitting MS or clinically isolated syndrome, maximum disease duration two years, as well available data...