A5025712718- Advanced X-ray and CT Imaging
- Medical Imaging Techniques and Applications
- Radiation Dose and Imaging
- Bone health and osteoporosis research
- Dental Radiography and Imaging
- Radiomics and Machine Learning in Medical Imaging
- Medical Imaging and Analysis
- Electrical and Bioimpedance Tomography
- Advanced Radiotherapy Techniques
- Anatomy and Medical Technology
- Spinal Fractures and Fixation Techniques
- Spine and Intervertebral Disc Pathology
- Shoulder Injury and Treatment
- Elbow and Forearm Trauma Treatment
- Bone and Joint Diseases
- Pelvic and Acetabular Injuries
- Orthopedic Surgery and Rehabilitation
- Osteoarthritis Treatment and Mechanisms
- Education, Psychology, and Social Research
- Vascular Tumors and Angiosarcomas
- Cardiac Imaging and Diagnostics
- MicroRNA in disease regulation
- Sarcoma Diagnosis and Treatment
- Welding Techniques and Residual Stresses
- COVID-19 diagnosis using AI
Klinikum rechts der Isar
2015-2025
Technical University of Munich
2015-2025
University of Pennsylvania
2020-2025
Hubei University of Arts and Science
2025
Xiangyang Central Hospital
2025
Zhongnan Hospital of Wuhan University
2025
Wuhan University
2025
California University of Pennsylvania
2021-2024
Jiangsu University
2018-2024
University Radiology
2018
Abstract The performance of a recently introduced spectral computed tomography system based on dual‐layer detector has been investigated. A semi‐anthropomorphic abdomen phantom for CT evaluation was imaged the at different radiation exposure levels ( CTDI vol 10 mG y, 20 y and 30 y). equipped with specific low‐contrast tissue‐equivalent inserts including water‐, adipose‐, muscle‐, liver‐, bone‐like materials variation in iodine concentrations. Additionally, size varied using extension rings...
To investigate the in vivo applicability of non-contrast-enhanced hydroxyapatite (HA)-specific bone mineral density (BMD) measurements based on dual-layer CT (DLCT).A spine phantom containing three artificial vertebral bodies with known HA densities was measured to obtain spectral data using DLCT and quantitative (QCT), simulating different patient positions grades obesity. BMD calculated from virtual monoenergetic images at 50 200 keV. HA-specific values 174 vertebrae 33 patients (66 ± 18...
Osteoporosis diagnosis using multidetector CT (MDCT) is limited to relatively high radiation exposure. We investigated the effect of simulated ultra-low-dose protocols on in-vivo bone mineral density (BMD) and quantitative trabecular assessment.Institutional review board approval was obtained. Twelve subjects with osteoporotic vertebral fractures 12 age- gender-matched controls undergoing routine thoracic abdominal MDCT were included (average effective dose: 10 mSv). Ultra-low examinations...
Background Mild stroke may lead to cognitive impairment, and it remains unclear whether intravenous thrombolysis (IVT) can mitigate deficits. This study investigates IVT help alleviate function impairment in patients further explores changes the topological properties of cerebral blood flow (CBF) networks. Methods observational prospectively enrolled 94 with acute mild ischemic (44 vs. 50 non-IVT) from two hospitals. A battery neuropsychological tests arterial spin labeling were performed...
Objectives Respiratory motion poses a significant challenge for clinical workflows in diagnostic imaging and radiation therapy. Many technologies such as artifact reduction tumor tracking have been developed to compensate its effect. To assess these technologies, respiratory phantoms (RMPs) are required preclinical testing environments, instance, computed tomography (CT). However, current CT RMPs highly simplified do not exhibit realistic tissue structures or deformation patterns. With the...
This study investigated simulated tube current reduction and sparse sampling for low-dose computed tomography (CT) regarding volumetric bone mineral density (vBMD) cortical thickness (Ct.Th) of the proximal femur. Sparse with dose reductions up to 90% may still allow extraction strength parameters clinically acceptable accuracy. We aimed investigate effects CT lowered on trabecular vBMD as well Ct.Th entire femur, its subregions, detailed spatial assessments. Clinical routine multi-detector...
To assess whether phantomless calcium-hydroxyapatite (HA) specific bone mineral density (BMD) measurements with dual-layer spectral computed tomography are accurate in phantoms and vertebral specimens. Ex-vivo human vertebrae (n = 13) a phantom containing different known HA concentrations were placed semi-anthropomorphic abdomen extension rings simulating degrees of obesity. Phantomless CT was performed at tube current settings (500, 250, 125 50 mAs). HA-specific BMD derived from...
. Deep learning reconstruction (DLR) algorithms exhibit object-dependent resolution and noise performance. Thus, traditional geometric CT phantoms cannot fully capture the clinical imaging performance of DLR. This study uses a patient-derived 3D-printed PixelPrint lung phantom to evaluate commercial DLR algorithm across wide range radiation dose levels.
Abstract Background Circular RNAs (circRNAs) play an important role in osteoarthritis (OA). However, the of circRNA OA is still unclear. Here, we explored and mechanism circ_0044235 OA. Methods CHON-001 cells were treated with IL-1β to establish model vitro. The levels circ_0044235, miR-375 phosphoinositide 3-kinase (PI3K) regulatory subunit 3 (PIK3R3) detected by quantitative real-time PCR. Cell count kit-8 assay flow cytometry used detect cell viability apoptosis. concentrations...
Purpose The exciting prospect of Spectral CT (SCT) using photon-counting detectors (PCD) will lead to new techniques in computed tomography (CT) that take advantage the additional spectral information provided. We introduce a method reduce metal artifact X-ray by incorporating knowledge obtained from SCT into statistical iterative reconstruction scheme. call our Spectral-driven Iterative Reconstruction (SPIR). Method proposed algorithm consists two main components: material decomposition and...
In modern clinical decision-support algorithms, heterogeneity in image characteristics due to variations imaging systems and protocols hinders the development of reproducible quantitative measures including for feature extraction pipelines. With help a reader study, we investigate ability provide consistent ground-truth targets by using patient-specific 3D-printed lung phantoms. PixelPrint was developed 3D-printing lifelike computed tomography (CT) phantoms directly translating images into...
X-ray and particle radiation therapy planning requires accurate estimation of local electron density within the patient body to calculate dose delivery tumour regions. We evaluate feasibility accuracy measurement using dual-layer computed tomography (DLCT), a recently introduced dual-energy CT technique.Two calibration phantoms were scanned with DLCT virtual monoenergetic images (VMIs) at 50 keV 200 generated. investigated two approaches obtain relative densities from these VMIs: fit an...
Abstract Multidetector computed tomography–based trabecular bone microstructure analysis ensures promising results in fracture risk prediction caused by osteoporosis. Because multidetector tomography is associated with high radiation exposure, its clinical routine use limited. Hence, this study, we investigated 11 thoracic midvertebral specimens whether texture parameters are comparable derived from (1) images reconstructed using statistical iterative reconstruction (SIR) and filtered back...
To assess whether bone marrow edema in patients with acute vertebral fractures can be accurately diagnosed based on three-material decomposition dual-layer spectral CT (DLCT). Acute (n = 41) and chronic 18) osteoporotic thoracolumbar as by MRI (hyperintense signal STIR sequences) 27 subjects (72 ± 11 years; 17 women) were assessed DLCT. Spectral data decomposed into hydroxyapatite, edema-equivalent, fat-equivalent density maps using an in-house-developed algorithm. Two radiologists, blinded...
To systematically evaluate the effects of virtual tube current reduction and sparse sampling on image quality vertebral fracture diagnostics in multi-detector computed tomography (MDCT). In routine MDCT scans 35 patients (80.0% females, 70.6 ± 14.2 years, 65.7% showing fractures), reduced radiation doses were retrospectively simulated by virtually lowering currents applying sampling, considering 50%, 25%, 10% original projections, respectively. Two readers evaluated items presence fractures....
Abstract Objectives Osteoporosis remains under-diagnosed, which may be improved by opportunistic bone mineral density (BMD) measurements on CT. However, correcting for the influence of intravenous iodine-based contrast agent is challenging. The purpose this study was to assess diagnostic accuracy iodine-corrected vertebral BMD derived from non-dedicated contrast-enhanced phantomless dual-layer spectral CT (DLCT) examinations. Methods Vertebral volumetric DLCT-BMD measured in native,...
Abstract This study aimed to evaluate the effect of dose reduction, by means tube exposure on bone strength prediction from finite-element (FE) analysis. Fresh thoracic mid-vertebrae specimens (n = 11) were imaged, using multi-detector computed tomography (MDCT), at different intensities X-ray exposures (80, 150, 220 and 500 mAs). Bone mineral density (BMD) was estimated mid-slice each specimen MDCT images. Differences in image quality geometry measured. FE analysis performed all predict...
Phantoms are essential tools for assessing and verifying performance in computed tomography (CT). Realistic patient-based lung phantoms that accurately represent textures densities developing evaluating novel CT hardware software. This study introduces PixelPrint, a 3D-printing solution to create patient-specific with accurate contrast textures. PixelPrint converts patient images directly into printer instructions, where density is modeled as the ratio of filament voxel volume emulate local...
The parameters of the spectrometer were analyzed in order to optimize performance spectral-domain optical coherence tomography (SD-OCT). Because probing depth is proportional spectral resolution, it can be increased with choice a higher resolution spectrometer, which implies greater pixel numbers and lower imaging speed, or by sacrificing part spectrum, compromises axial side lobes. With dynamic range 8 bits more, signal-to-noise ratio remains constant for different noise levels. results...
Abstract The objective of this study is to create patient-specific phantoms for computed tomography (CT) that possess accurate densities and exhibit visually realistic image textures. These qualities are crucial evaluating CT performance in clinical settings. builds upon a previously presented 3D printing method (PixelPrint) by incorporating soft tissue bone structures. We converted patient DICOM images directly into printer instructions using PixelPrint utilized calcium-doped filament...