A5051462025- Advanced X-ray and CT Imaging
- Radiation Dose and Imaging
- Medical Imaging Techniques and Applications
- Dental Radiography and Imaging
- Bone health and osteoporosis research
- Cardiac Imaging and Diagnostics
- Bone health and treatments
- Advanced X-ray Imaging Techniques
- Medical Imaging and Analysis
- Optical Imaging and Spectroscopy Techniques
- Acute Ischemic Stroke Management
- Photoacoustic and Ultrasonic Imaging
- Advanced Radiotherapy Techniques
- Infrared Thermography in Medicine
- Advanced MRI Techniques and Applications
Technical University of Munich
2018-2024
Klinikum rechts der Isar
2018-2024
To investigate the in vivo applicability of non-contrast-enhanced hydroxyapatite (HA)-specific bone mineral density (BMD) measurements based on dual-layer CT (DLCT).A spine phantom containing three artificial vertebral bodies with known HA densities was measured to obtain spectral data using DLCT and quantitative (QCT), simulating different patient positions grades obesity. BMD calculated from virtual monoenergetic images at 50 200 keV. HA-specific values 174 vertebrae 33 patients (66 ± 18...
To assess whether bone marrow edema in patients with acute vertebral fractures can be accurately diagnosed based on three-material decomposition dual-layer spectral CT (DLCT). Acute (n = 41) and chronic 18) osteoporotic thoracolumbar as by MRI (hyperintense signal STIR sequences) 27 subjects (72 ± 11 years; 17 women) were assessed DLCT. Spectral data decomposed into hydroxyapatite, edema-equivalent, fat-equivalent density maps using an in-house-developed algorithm. Two radiologists, blinded...
Abstract Objectives Osteoporosis remains under-diagnosed, which may be improved by opportunistic bone mineral density (BMD) measurements on CT. However, correcting for the influence of intravenous iodine-based contrast agent is challenging. The purpose this study was to assess diagnostic accuracy iodine-corrected vertebral BMD derived from non-dedicated contrast-enhanced phantomless dual-layer spectral CT (DLCT) examinations. Methods Vertebral volumetric DLCT-BMD measured in native,...
Nowadays, there is no method to quantitatively characterize the material composition of acute ischemic stroke thrombi prior intervention, but dual-energy CT (DE-CT) offers imaging-based multimaterial decomposition. We retrospectively investigated ex vivo using DE-CT with histological analysis as a reference.
Abstract Dual-Energy Computed Tomography is of significant clinical interest due to the possibility material differentiation and quantification. In current routine, primarily two materials are differentiated, e.g., iodine soft-tissue. A ventilation-perfusion-examination acquired within a single CT scan requires contrast agents, xenon gadolinium, three-material differentiation. study, we have developed solution for ventilation-perfusion-examination. landrace pig was examined using dual-layer...
The aim of this study is to assess whether perifocal bone marrow edema (BME) in patients with osteoid osteoma (OO) can be accurately detected on dual-layer spectral CT (DLCT) three-material decomposition. To that end, 18 OO (25.33 ± 12.44 years; 7 females) were pairwise-matched (26.72 9.65 9 admitted for suspected pathologies other than the same anatomic location but negative imaging findings. All examined DLCT and MRI. data was decomposed into hydroxyapatite water- fat-equivalent volume...
Abstract The separation of mixtures substances into their individual components plays an important role in many areas science. In medical imaging, one method is the established analysis using dual-energy computed tomography. However, when analyzing consisting more than three basis materials, a physical limit reached that no longer allows this standard analysis. addition, X-ray attenuation coefficients chemically complicated materials may not be known and also cannot determined by other or...
Ischemic heart disease is the globally leading cause of death. When using coronary CT angiography, functional hemodynamics within myocardium remain uncertain. In this study myocardial perfusion imaging iodine contrast agent demonstrated to strongly improve assessment disorders. However, a retrieval such dynamics Hounsfield units from conventional poses concerns with respect beam-hardening effects and low contrast-to-noise ratio (CNR). Dual-energy offers novel approaches overcome...
Abstract Background Dark-field radiography imaging exploits the wave character of x-rays to measure small-angle scattering on material interfaces, providing structural information with low radiation exposure. We explored potential dark-field bone microstructure improve assessment strength in osteoporosis. Methods prospectively examined 14 osteoporotic/osteopenic and 21 non-osteoporotic/osteopenic human cadaveric vertebrae (L2–L4) a clinical system, micro-computed tomography (CT), spectral...
In radiation treatment planning (RTP), CT reconstruction that combats projection truncation artifacts induced by the patient being positioned partially outside scan field-of-view (FOV) needs to maintain high geometric and Hounsfield Unit (HU) accuracy FOV. A new image method has been proposed for clinical helical simulation scans. This generates support images using Discrete Algebraic Reconstruction Technique accurately estimate contours FOV then uses guide extension. The improved in objects...
Abstract Background To investigate the detection capabilities of myocardial perfusion defects dual-energy computed tomography (CT) technology using time-resolved iodine-based maps for functional assessment coronary stenosis in a dynamic heart phantom. Methods An anatomical model was designed three-dimensional (3D) printing technique. The lumen right artery reduced to 25% original areal cross-section. Scans were acquired with 64-slice dual-layer CT equipment protocol 36 time points. For...
Purpose or Learning Objective: To assess whether bone marrow edema in patients with osteoid osteoma (OO) can be accurately diagnosed based on three-material decomposition spectral dual-layer computed tomography (DLCT).
Zielsetzung Mittels 2D Scoutscans aus Dual-Energy-CT Daten sollen Knochendichte (BMD) – Karten berechnet werden und die diagnostische Bedeutung für ein opportunistisches Osteoporose-Screening evaluiert werden.
Abstract Background To determine whether denoised areal bone mineral density (BMD) measurements from scout scans in spectral detector computed tomography (CT) correlate with volumetric trabecular BMD for opportunistic osteoporosis screening. Methods A 64-slice single-source dual-layer CT scanner was used to acquire scan data of 228 lumbar vertebral bodies within 57 patients. Scout anterior–posterior (AP) view were performed a dose < 0.06 mSv and spectrally decomposed into (aBMD) values....
Es sollte untersucht werden, ob Knochenmarködeme und somit frische Wirbelkörperfrakturen nach einer 3-Material-Dekomposition basierend auf spektralen Dual-Layer CT-Bilddaten (SDCT) adäquat diagnostiziert werden können.
Anhand von in-vivo-Messungen sollte die Nutzbarkeit der Hydroxylapatit-(HA)-spezifischen Knochendichtemessung (BMD-Messung) basierend auf Dual-Layer Spektral-CT (DLCT) untersucht werden.
Objectives: To assess the value of opportunistic hydroxyapatite (HA)-specific vertebral bone mineral density (BMD) measurements derived from contrast-enhanced phantomless dual-layer spectral computed tomography (DLCT) examinations.
Zielsetzung Im Rahmen dieser Studie sollte die Möglichkeit einer simultanen Xenon-Ventilation und Gadolinium-Perfusion mittels Computertomografie (CT) evaluiert werden. Hierfür ein Algorithmus zur behelfsmäßigen Dreimaterialdifferenzierung verwendet
Zielsetzung Entwicklung und erste Validierung eines Algorithmus zur quantitativen Bestimmung der myokardialen Perfusion mittels spektraler Computertomografie in einem Schweinemodell.