A5076849307- Advanced X-ray Imaging Techniques
- Advanced X-ray and CT Imaging
- X-ray Spectroscopy and Fluorescence Analysis
- Medical Imaging Techniques and Applications
- Digital Holography and Microscopy
- Advanced MRI Techniques and Applications
- Crystallography and Radiation Phenomena
- Radiation Dose and Imaging
- Advanced Electron Microscopy Techniques and Applications
- Laser-Plasma Interactions and Diagnostics
- Radiomics and Machine Learning in Medical Imaging
- Adipose Tissue and Metabolism
- Digital Radiography and Breast Imaging
- Astrophysical Phenomena and Observations
- Renal cell carcinoma treatment
- Calibration and Measurement Techniques
- Nuclear Physics and Applications
- Exercise and Physiological Responses
- Veterinary Equine Medical Research
- Bone health and osteoporosis research
- Cardiac Imaging and Diagnostics
- Infrared Thermography in Medicine
- Dental Radiography and Imaging
- Cryospheric studies and observations
- Heat shock proteins research
Technical University of Munich
2015-2025
Klinikum rechts der Isar
2020-2023
Ludwig-Maximilians-Universität München
2017
Abstract The possibility to perform high-sensitivity X-ray phase-contrast imaging with laboratory grating-based computed tomography (gbPC-CT) setups is of great interest for a broad range high-resolution biomedical applications. However, achieving high sensitivity gbPC-CT still poses challenge because several factors such as the reduced flux, polychromaticity spectrum and limited coherence source reduce performance in comparison at synchrotron facilities. In this work, we present our...
Abstract Background A significant proportion of false positive recalls mammography‐screened women is due to benign breast cysts and simple fibroadenomas. These lesions appear mammographically as smooth‐shaped dense masses require the recalling for a ultrasound obtain complementary imaging information. They can be identified safely by with no need further assessment or treatment. Purpose Grating‐based x‐ray dark‐field allows contrast formation based on both attenuation small‐angle scattering...
Phase-contrast mammography using laboratory X-ray sources is a promising approach to overcome the relatively low sensitivity and specificity of clinical, absorption-based screening. Current research mostly centered on identifying potential diagnostic benefits arising from phase-contrast dark-field benchmarking latter with conventional state-of-the-art imaging methods. So far, little effort has been made adjust this novel technique clinical needs. In article, we address key points for...
Breast microcalcifications play an essential role in the detection and evaluation of early breast cancer clinical diagnostics. However, digital mammography, are merely graded with respect to their global appearance within mammogram, while interior microstructure remains spatially unresolved therefore not considered risk stratification. In this article, we exploit sub-pixel resolution sensitivity X-ray dark-field contrast for microcalcification assessment. We demonstrate that micromorphology,...
Conventional X-ray attenuation-based contrast is inherently low for the soft-tissue components of female breast. To overcome this limitation, we investigate diagnostic merits arising from dark-field mammography by means certain tumour structures enclosed within freshly dissected mastectomy samples. We performed grating-based absorption, absolute phase and three samples containing bi- multifocal carcinoma using a compact, laboratory Talbot-Lau interferometer. Preoperative in vivo imaging...
Phase-contrast x-ray imaging is a promising improvement of conventional absorption-based mammography for early tumor detection. This potential has been demonstrated recently, utilizing structured gratings to obtain differential phase and dark-field scattering images. However, the inherently anisotropic sensitivity proposed mono-directional approach yields only insufficient diagnostic information, low highly oriented structures. To overcome these limitations, we present two-directional...
Background Fibroadenoma is the most common benign solid breast lesion type and a very cause for histologic assessment. To justify conservative therapy, highly specific discrimination between fibroadenomas other lesions crucial. Phase-contrast imaging offers improved soft-tissue contrast differentiability of fine structures combined with potential 3-dimensional imaging. In this study we assessed grating-based phase-contrast CT visualizing diagnostically relevant features fibroadenomas....
The conventional form of computed tomography using X-ray attenuation without any contrast agents is limited use for the characterization soft tissue in many fields medical and biological studies. Grating-based phase-contrast (gbPC-CT) a promising alternative imaging method solving low need agent. While highly sensitive measurements are possible sources spatial resolution does often not fulfill requirements specific tasks, such as visualization pathologies. focus this study increase loss...
Grating-based X-ray phase-contrast (gbPC) is an imaging method involving optical gratings that typically employs the Talbot self-imaging effect. phase contrast known to provide significant benefits for biomedical imaging. To investigate these gbPC, a high-sensitivity gbPC micro-CT setup small biological samples has been constructed. A projection measurement simultaneously retrieves transmittance, differential-phase and dark-field modalities of sample. Phase stepping, most common acquisition...
The demand for quantitative medical imaging is increasing in the ongoing digitalization. Conventional computed tomography (CT) energy-dependent and therefore of limited comparability. In contrast, dual-energy CT (DECT) allows determination absolute image contrast quantities, namely electron density effective atomic number, already established clinical radiology radiation therapy. Grating-based phase-contrast (GBPC-CT) an experimental X-ray technique that also measurement number. However,...
Photon-counting detectors provide several potential advantages in biomedical x-ray imaging including fast and readout noise free data acquisition, sharp pixel response, high dynamic range. Grating-based phase-contrast is a method, which delivers soft-tissue contrast strongly benefits from photon-counting properties. However, silicon sensors commonly used have low quantum efficiency for mid- to high-energies, limits throughput capabilities when combined with grating-based phase imaging. In...
X-ray phase-contrast imaging is a novel technology that achieves high soft-tissue contrast. Although its clinical impact still under investigation, the technique may potentially improve diagnostics. In conventional attenuation-based computed tomography, radiological diagnostics are quantified by Hounsfield units. Corresponding units for have been recently introduced, enabling setup-independent comparison and standardized interpretation of results. Thus far, experimental values few tissue...
Grating based X-ray differential phase contrast imaging (DPCI) allows for high of materials with similar absorption characteristics. In the last years' publications, small animals or parts human body like breast, hand, joints blood vessels have been studied. Larger object s could not be investigated due to restricted field view limited by available grating area. this paper, we report on a new stitching method increase area significantly: individual gratings are merged carrier substrate....
The extent of intraductal carcinoma in situ (DCIS) is commonly underestimated due to the discontinuous growth and lack microcalcifications. Specimen radiography has been established reduce rate re-excision. However, predictive value for margin assessment with conventional specimen DCIS low. In this study we assessed potential grating-based phase-contrast computed tomography (GBPC-CT) at X-ray sources containing samples.GBPC-CT was performed on four ex-vivo breast specimens invasive...
Currently, the detection of retained wood is a frequent but challenging task in emergency care. The purpose this study to demonstrate improved foreign-body with novel approach preclinical X-ray dark-field radiography.At x-ray radiography, setup resolution and sensitivity for simultaneous wooden metallic particles have been evaluated phantom study. A clinical setting has simulated formalin fixated human hand where different typical materials inserted. Signal-to-noise ratios (SNR) determined...
Grating based X-ray phase contrast imaging is on the verge of being applied in clinical settings. To achieve this goal, compact setups with high sensitivity and dose efficiency are necessary. Both can be increased by eliminating unwanted absorption beam path, which mainly due to grating substrates. Fabrication gratings via deep lithography address issue replacing commonly used silicon substrate materials lower that fulfill certain boundary conditions. Gratings were produced both graphite...
Differential phase-contrast X-ray imaging using a Talbot-Lau interferometer has recently shown promising results for applications in medical imaging. However, reducing the applied radiation dose remains major challenge. In this study, we consider realization of high Talbot order to increase signal-to-noise ratio low-dose applications. The quantitative performance π and π/2 systems at orders is analyzed through simulations, design energy spectrum are optimized mammography. It found that...
Abstract Current clinical imaging methods face limitations in the detection and correct characterization of different subtypes renal cell carcinoma (RCC), while these are important for therapy prognosis. The present study evaluates potential grating-based X-ray phase-contrast computed tomography (gbPC-CT) visualization human RCC subtypes. results 23 ex vivo formalin-fixed kidney specimens obtained with CT were compared to absorption-based (gbCT), a 3T MRI validated using histology. Regions...
X-ray phase-contrast imaging is an effective approach to drastically increase the contrast and sensitivity of microtomographic techniques. Numerous approaches depict real part complex-valued refractive index a specimen are nowadays available. A comparative study using experimental data from grating-based interferometry propagation-based phase combined with single-distance retrieval applied non-homogeneous sample presented (acquired at beamline ID19-ESRF). It shown that can handle density...
Grating-based x-ray differential phase-contrast imaging (DPCI) is capable of acquiring information based on phase-shift and dark-field signal, in addition to conventional absorption-contrast. Thus DPCI gives an advantage investigate composite materials with component wise similar absorption properties like soft tissues. Due technological challenges fabricating high quality gratings over a large extent, the field view (FoV) systems limited grating area couple square centimeters. For many...
In this article, we report on a novel acquisition scheme for time- and dose-saving retrieval of dark-field data in grating-based phase-contrast imaging. comparison to currently available techniques, the proposed approach only requires two phase steps. More importantly, our method is capable accurately retrieving signal where conventional approaches fail, instance case very low photon statistics. Finally, successfully extend two-shot imaging tomographic investigations, by implementing an...
Grating-based phase-contrast computed tomography (gb-PCCT) relies on x-ray refraction instead of absorption to generate high-contrast images in biological soft tissue. The aim this study was evaluate the potential gb-PCCT for depiction structural changes heart disease.Four human specimens from patients with hypertensive disease, ischemic dilated and cardiac lipomatosis were examined. setup consisted an tube (40 kV, 70 mA), grating-interferometer, detector, allowed simultaneous acquisition...