A5060879844- Advanced X-ray Imaging Techniques
- X-ray Spectroscopy and Fluorescence Analysis
- Advanced Electron Microscopy Techniques and Applications
- Laser-Plasma Interactions and Diagnostics
- Crystallography and Radiation Phenomena
- Advanced X-ray and CT Imaging
- Radio Frequency Integrated Circuit Design
- Advancements in Photolithography Techniques
- Microwave Engineering and Waveguides
- Medical Imaging Techniques and Applications
- Microwave and Dielectric Measurement Techniques
- Astrophysical Phenomena and Observations
- Optical measurement and interference techniques
- Nuclear Physics and Applications
- Advanced Surface Polishing Techniques
- Ion-surface interactions and analysis
- Photonic and Optical Devices
- Advanced optical system design
- Astrophysics and Star Formation Studies
- Electron and X-Ray Spectroscopy Techniques
- Advanced Measurement and Metrology Techniques
- Optical Coatings and Gratings
- Particle Accelerators and Free-Electron Lasers
- Semiconductor Quantum Structures and Devices
- 3D IC and TSV technologies
GlobalFoundries (Germany)
2015-2024
Paul Scherrer Institute
2018-2022
GSI Helmholtz Centre for Heavy Ion Research
2022
Karlsruhe Institute of Technology
2013-2018
We present a method for x-ray phase-contrast imaging and metrology applications based on the sample-induced modulation subsequent computational demodulation of random or periodic reference interference pattern. The proposed unified modulated pattern analysis (UMPA) technique is versatile approach allows tuning signal sensitivity, spatial resolution, scan time. characterize demonstrate its potential high-sensitivity, quantitative phase imaging, to overcome limitations existing methods.
Abstract X-ray chest radiography is an inexpensive and broadly available tool for initial assessment of the lung in clinical routine, but typically lacks diagnostic sensitivity detection pulmonary diseases their early stages. Recent dark-field (XDF) imaging studies on mice have shown significant improvements imaging-based diagnostics. Especially case diagnosis chronic obstructive disease (COPD), XDF clearly outperforms conventional radiography. However, a translation this technique towards...
Abstract The possibility to perform high-sensitivity X-ray phase-contrast imaging with laboratory grating-based computed tomography (gbPC-CT) setups is of great interest for a broad range high-resolution biomedical applications. However, achieving high sensitivity gbPC-CT still poses challenge because several factors such as the reduced flux, polychromaticity spectrum and limited coherence source reduce performance in comparison at synchrotron facilities. In this work, we present our...
X-ray grating-based interferometry promises unique new diagnostic possibilities in medical imaging and materials analysis. To transfer this method from scientific laboratories or small-animal applications to clinical radiography applications, compact setups with a large field of view (FoV) are required. Currently the FoV is limited by grating area, which restricted due complex manufacturing process. One possibility increase tiling individual tiles create one area mounted on carrier...
The availability of intense soft x-ray beams with tunable energy and polarization has pushed the development highly sensitive, element-specific, noninvasive microscopy techniques to investigate condensed matter high spatial temporal resolution. short wavelengths x-rays promise reach resolutions in deep single-digit nanometer regime, providing unprecedented access magnetic phenomena at fundamental length scales. Despite considerable efforts techniques, a two-dimensional resolution 10 nm not...
Here a direct comparison is made between various X-ray wavefront sensing methods with application to optics alignment and focus characterization at free-electron lasers (XFELs). Focus optimization XFEL beamlines presents unique challenges due high peak powers as well beam pointing instability, meaning that techniques capable of single-shot measurement probe the an out-of-focus location are desirable. The chosen for include single-phase-grating Talbot interferometry (shearing interferometry),...
Imaging large areas of a sample non-destructively and with high resolution is great interest for both science industry. For scanning coherent X-ray diffraction microscopy, i. e., ptychography, the achievable scan area at given spatial limited by photon flux modern sources. Multibeam ptychography can improve speed several parallel mutually incoherent beams, e. g., generated illuminating multiple focusing optics in partially beam. The main difficulty this scheme robust separation superimposed...
Journal Article 7 nm Spatial Resolution in Soft X-ray Microscopy Get access Benedikt Rösner, Rösner Paul Scherrer Institut, 5232 Villigen PSI, Switzerland benedikt.roesner@psi.ch Search for other works by this author on: Oxford Academic Google Scholar Frieder Koch, Koch Florian Döring, Döring Vitaliy A Guzenko, Guzenko Markus Meyer, Meyer Department Chemistry and Pharmacy, FAU Erlangen-Nürnberg, Egerlandstr. 3, 91058 Erlangen, Germany Joshua L Ornelas, Ornelas Andreas Späth, Späth Rainer H...
The recent success in the development of high precision printing techniques allows one to manufacture free-standing polymer structures quality. Two-photon polymerization lithography is a mask-less technique with down 100 {\mu}m resolution that provides full geometric freedom. It has recently been applied nanofabrication X-ray compound refractive lenses (CRLs). In this article we report on characterization two sets CRLs different design produced by two-photon induced lithography.
The extension of transient grating spectroscopy to the x-ray regime will create numerous opportunities, ranging from study thermal transport in ballistic charge, spin, and energy transfer processes with atomic spatial femtosecond temporal resolution. Studies involving complicated split-and-delay lines have not yet been successful achieving this goal. Here we propose a novel, simple method based on Talbot effect for converging beams, which can easily be implemented at current free electron...
Modern subtractive and additive manufacturing techniques present new avenues for X-ray optics with complex shapes patterns. Refractive phase plates acting as glasses have been fabricated, spherical aberration in refractive lenses made from beryllium has successfully corrected. A diamond plate by femtosecond laser ablation was found to improve the Strehl ratio of a lens stack numerical aperture (NA) 0.88 × 10 −3 at 8.2 keV 0.1 0.7. polymer printing achieved an increase 35 NA 0.18 0.15 0.89,...
Nondestructive imaging with both a large field of view and high spatial resolution is crucial to understand complex materials processes in science technology. X-ray ptychography can provide highest but limited the by acquisition time coherent flux at modern x-ray sources. By multi-beam ptychography, sample be imaged parallel several spatially separated mutually incoherent beams. We have implemented this method using 3D nanoprinted optics create tailor-made arrays. The use printing allows us...
Grating based X-ray differential phase contrast imaging (DPCI) allows for high of materials with similar absorption characteristics. In the last years' publications, small animals or parts human body like breast, hand, joints blood vessels have been studied. Larger object s could not be investigated due to restricted field view limited by available grating area. this paper, we report on a new stitching method increase area significantly: individual gratings are merged carrier substrate....
We report on the implementation and characterization of grating interferometry operating at an x-ray energy 183 keV. With possibility to use this technique high energies, bigger specimens could be studied in a quantitative way. Also, imaging strongly absorbing will benefit from advantages phase dark-field signals provided by interferometry. However, especially these photon energies performance absorption becomes key point quality system, because lines need keep their small width couple...
Grating based X-ray phase contrast imaging is on the verge of being applied in clinical settings. To achieve this goal, compact setups with high sensitivity and dose efficiency are necessary. Both can be increased by eliminating unwanted absorption beam path, which mainly due to grating substrates. Fabrication gratings via deep lithography address issue replacing commonly used silicon substrate materials lower that fulfill certain boundary conditions. Gratings were produced both graphite...
Refractive X-ray lenses are in use at a large number of synchrotron experiments. Several materials and fabrication techniques available for their production, each having own strengths drawbacks. We present grating interferometer the quantitative analysis single refractive employ it study beryllium point focus lens polymer line lens, highlighting differences outcome methods. The residuals fit to phase gradient used quantify local defects, while shape aberrations quantified by decomposition...
Grating-based x-ray differential phase-contrast imaging (DPCI) is capable of acquiring information based on phase-shift and dark-field signal, in addition to conventional absorption-contrast. Thus DPCI gives an advantage investigate composite materials with component wise similar absorption properties like soft tissues. Due technological challenges fabricating high quality gratings over a large extent, the field view (FoV) systems limited grating area couple square centimeters. For many...
A provisional setup for X-ray microprobe experiments at 35 keV is described. It based on compound refractive lenses (CRLs) nanofocusing and a Vortex silicon drift detector with 2 mm sensor thickness increased sensitivity high energies. The Microprobe experiment (PETRA III) generally uses Kirkpatrick-Baez mirrors submicrometer focusing in the energy range of 5–21 keV. However, various types scanning microscopy require higher excitation CRL optics were characterized by ptychography...
The current advances in new generation X-ray sources are calling for the development and improvement of high-performance optics. Techniques high-sensitivity phase sensing wavefront characterisation, preferably performed at-wavelength, increasingly required quality control, optimisation such devices. We here show that recently proposed unified modulated pattern analysis (UMPA) can be used these purposes. characterised two polymer refractive lenses quantified effect beam damage shape errors on...
X-ray differential phase-contrast imaging (DPCI) using a Talbot–Lau interferometer at conventional tube source has continuously found applications since its first demonstration. It requires high aspect ratio grating structures with feature size in the micrometer range that are fabricated lithographie, galvanik und abformung technology. To overcome current limitation area, an exposure strategy—continuous exposure—has been developed. In this case, mask is fixed respect to synchrotron beam and...
The transmission X-ray microscope (TXM) on the Anatomix beamline welcomed its first nano-tomography users in 2019. instrument is based diffractive optics and works range of energies from 7 keV to 21 keV. A spatial resolution 3D volumes better than 100 nm can be achieved. design allows imaging samples air, local tomography as well off-axis scans are possible. Scans below above K-edges made access elemental distribution. TXM serves materials science bio-medical field.
Point focus x-ray mosaic lenses are limited in aperture by the aspect ratio that can be reached micro fabrication process. In lithography based processes, which used to fabricate lens pillar structures, achievable is restricted structure collapse due capillary forces occur during drying after development. Capillary avoided freeze drying, hence avoiding direct phase change from liquid gas. Substituting conventional using cyclohexane at a temperature of −10 °C, we could increase for triangular...