A5014041147- Advanced X-ray and CT Imaging
- Radiation Dose and Imaging
- Digital Radiography and Breast Imaging
- Medical Imaging Techniques and Applications
- Diamond and Carbon-based Materials Research
- Advanced X-ray Imaging Techniques
- High-pressure geophysics and materials
- Optical Imaging and Spectroscopy Techniques
- Digital Holography and Microscopy
- X-ray Spectroscopy and Fluorescence Analysis
- Electronic and Structural Properties of Oxides
- Integrated Circuits and Semiconductor Failure Analysis
- Dental Radiography and Imaging
- Advanced Surface Polishing Techniques
- Advanced Radiotherapy Techniques
- Ion-surface interactions and analysis
- Orthopedic Infections and Treatments
- Advanced Semiconductor Detectors and Materials
- CCD and CMOS Imaging Sensors
- Optical Coherence Tomography Applications
- Geophysical Methods and Applications
- Radiomics and Machine Learning in Medical Imaging
Tris Pharma (United States)
2024
German Cancer Research Center
2018
Paul Scherrer Institute
2015-2016
Swiss Light Source
2015
University College London
2013
University of Surrey
2007-2010
Purpose: To provide an x‐ray phase contrast imaging (XPCI) method working with conventional sources that could be readily translated into clinical practice. XPCI shows potential in synchrotron studies but attempts at translating it for use are subject to limitations terms of field view, stability, exposure time, and possibly most importantly, delivered dose. Methods: Following the adaptation our “edge‐illumination” technique through masks, authors have further modified design such masks...
Abstract In X-ray grating interferometry, dark-field contrast arises due to partial extinction of the detected interference fringes. This is also called visibility reduction and attributed small-angle scattering from unresolved structures in imaged object. recent years, analytical quantitative frameworks have been developed for highly diluted monodisperse microsphere suspensions with maximum 6% volume fraction. These assume that particles are separated by large enough distances, which make...
Photon-counting detectors provide several potential advantages in biomedical x-ray imaging including fast and readout noise free data acquisition, sharp pixel response, high dynamic range. Grating-based phase-contrast is a method, which delivers soft-tissue contrast strongly benefits from photon-counting properties. However, silicon sensors commonly used have low quantum efficiency for mid- to high-energies, limits throughput capabilities when combined with grating-based phase imaging. In...
State-of-the-art X-ray breast imaging (BI) modalities such as digital tomosynthesis (DBT), contrast enhanced spectral mammography (CESM) and CT (BCT) impose demanding requirements on detectors. This work studies the performance of a GaAs two-threshold photon-counting detector (PCD) prototype for BI relevant spectra. The has 75 μm pixel size, two calibrated energy thresholds from 8 to 60 keV, x 4 cm<sup>2</sup> area 0.5 mm thick sensor. spectra used were 28 35 kVp with 2 Al filtration...
We have studied the effects of irradiation induced damage on detector response a synthetic single crystal diamond radiation detector. Before introducing damage, spatial variation was investigated using highly focused 2.6 MeV proton beam. A very uniform close to 100% charge collection efficiency (CCE) over whole contact area found at applied electric field strengths as low 0.4 V μm–1. At lower biases, time dependent polarisation phenomena were observed and clearly reduced average signal...
Purpose: The purpose of this study was to evaluate the potential a prototype gallium arsenide (GaAs) photon-counting detector (PCD) for imaging breast. Approach: First, contrast-to-noise ratio (CNR) using different aluminum/poly(methyl methacrylate) (PMMA) phantoms thicknesses were measured. Second, microcalcification detection accuracy receiver operating characteristic with three observers reading an ensemble images Finally, feasibility GaAs system two energy bins contrast-enhanced...
Objectives The aims of this study were to test whether spectral photon-counting radiography (SPCR) is able identify and distinguish different crystals associated with arthropathies in vitro validate findings a gouty human third toe ex vivo. Materials Methods Industry-standard calibration rods calcium pyrophosphate, hydroxyapatite (HA), monosodium urate (MSU) scanned SPCR an experimental setup. Each material was available at 3 concentrations, dedicated detector used for SPCR, whereas...
Raw-data–based material decomposition in spectral CT using photon–counting energy–selective detectors relies on a precise forward model that predicts count–rate given intersection lengths for each material. This re- quires extensive system–specific measurements or calibration techniques. Existing calibrations either estimate detected spectrum and are able to account spectrally distorted assumptions correct the predicted count rate correction function can accommodate rate–dependent effects...
X-ray photon counting detectors featuring high-Z sensor materials such as CdTe, CdZnTe and GaAs have the possibility to greatly improve field of medical imaging. In this work, we investigated energy resolving capabilities imaging performance two novel proof-of-concept hybrid based on IBEX ASIC Chromium-compensated direct-detection material targeted for applications. The sensors feature a pixel size 75 μm different thicknesses — 300 500 μm. Spectral properties were assessed by analyzing...
Photon-counting detector technology using directly converting high-Z sensor materials has recently gained popularity in medical imaging due to its capability reduce patient dose, increase spatial resolution and provide single shot multienergy information. However, applications, the novel is not yet widely used technical challenges manufacturing gap-less detectors with large areas. Here, a nearly gap-less, large-area, multi-energy photoncounting prototype presented which was built existing...
The purpose of this study was to evaluate the performance mammography images acquired with a prototype Gallium Arsenide (GaAs) photon counting detector. contrast noise ratio measured using different aluminum/PMMA phantoms thicknesses. In addition, microcalcification detection accuracy evaluated receiver operating characteristic (ROC) three observers reading an ensemble for each case. For both studies, comparisons were made commercial system. estimated by imaging 18, 36 and 110 μm thick...