A5003715286- Advanced X-ray Imaging Techniques
- Advanced X-ray and CT Imaging
- Medical Imaging Techniques and Applications
- Photoacoustic and Ultrasonic Imaging
- Digital Radiography and Breast Imaging
- Advanced Electron Microscopy Techniques and Applications
- Infrared Thermography in Medicine
- Radiation Dose and Imaging
- Advanced MRI Techniques and Applications
- Digital Holography and Microscopy
- X-ray Spectroscopy and Fluorescence Analysis
Technical University of Munich
2018-2025
California University of Pennsylvania
2023
TU Dortmund University
2019
Abstract Background A significant proportion of false positive recalls mammography‐screened women is due to benign breast cysts and simple fibroadenomas. These lesions appear mammographically as smooth‐shaped dense masses require the recalling for a ultrasound obtain complementary imaging information. They can be identified safely by with no need further assessment or treatment. Purpose Grating‐based x‐ray dark‐field allows contrast formation based on both attenuation small‐angle scattering...
Photon-counting detectors provide several potential advantages in biomedical x-ray imaging including fast and readout noise free data acquisition, sharp pixel response, high dynamic range. Grating-based phase-contrast is a method, which delivers soft-tissue contrast strongly benefits from photon-counting properties. However, silicon sensors commonly used have low quantum efficiency for mid- to high-energies, limits throughput capabilities when combined with grating-based phase imaging. In...
With the introduction of screening mammography, mortality rate breast cancer has been reduced throughout last decades. However, many women undergo unnecessary subsequent examinations due to inconclusive diagnoses from mammography. Two pathways appear especially promising reduce number false-positive diagnoses. In a clinical study, mammography using synchrotron radiation was able clarify diagnosis in majority cases. The second highly valued approach focuses on application phase-sensitive...
Accurately monitoring the extent of freezing in biological tissue is an important requirement for cryoablation, a minimally invasive cancer treatment that induces cell death by with cryoprobe. During procedure, required to avoid unnecessary harm surrounding healthy and ensure tumor properly encapsulated. One commonly used method attenuation-based computed tomography (CT), which visualizes ice ball utilizing its hypoattenuating properties compared unfrozen tissue. However, contrast between...
For early breast cancer detection, mammography is nowadays the commonly used standard imaging approach, offering a valuable clinical tool for visualization of suspicious findings like microcalcifications and tumors within breast. However, due to superposition anatomical structures, sensitivity screening limited. Within last couple years, implementation contrast-enhanced spectral (CESM) based on K-edge subtraction (KES) helped improve identification classification uncertain findings. In this...
<title>Abstract</title> The introduction of mammography screening programs has significantly reduced breast cancer mortality rates. Nevertheless, some lesions remain undetected, especially in dense tissue. Studies have shown that phase-contrast imaging can improve diagnosis by increasing soft tissue contrast. Furthermore, grating-based enables the simultaneous acquisition absorption-, phase-contrast, and scattering, so-called dark-field images. latter allows classification...
Abstract The introduction of mammography screening programs has significantly reduced breast cancer mortality rates. Nevertheless, some lesions remain undetected, especially in dense tissue. Studies have shown that phase-contrast imaging can improve diagnosis by increasing soft tissue contrast. Furthermore, grating-based enables the simultaneous acquisition absorption, phase-contrast, and scattering, so-called dark-field images. latter allows classification microcalcifications. In addition,...
In the last decade, grating-based phase-contrast computed tomography (gbPC-CT) has received growing interest. It provides additional information about refractive index decrement in sample. This signal shows an increased soft-tissue contrast. However, resolution dependence of poses a challenge: its contrast enhancement is overcompensated by low low-dose applications such as clinical tomography. As result, implementation gbPC-CT currently tied to higher dose. To reduce dose, we introduce...
Dual-source photon-counting computed tomography (PCCT) enables a novel ultra-high-resolution (UHR) scanning mode that can provide UHR conventional images (0.2 mm) as well spectral results (0.4 mm). To evaluate the spatial resolution and quantitative capabilities of mode, with focus on thoracic imaging, PixelPrint lung phantom mimicking interstitial disease honeycombing iodine rods different diameters concentrations directly attached to were scanned at doses from 1.0 7.5 mGy. Virtual...
Purpose: Although the mortality rate of breast cancer was reduced with introduction screening mammography, many women undergo unnecessary subsequent examinations due to inconclusive diagnoses. Superposition anatomical structures especially within dense breasts in conjunction inherently low soft tissue contrast absorption images compromises image quality. This can be overcome by phase-contrast imaging. Approach: We analyze spatial resolution grating-based multimodal mammography using a...
Abstract Cryoablation is a minimally invasive treatment option for malignancies in which cell death induced by freezing tissue with cryoprobe. However, the extent of frozen region must be monitored to avoid unnecessary damage surrounding healthy and ensure encapsulation tumor. One commonly used monitoring method, attenuation-based computed tomography (CT), allows visualization ice ball using its hypoattenuating properties compared unfrozen tissue. contrast between remains low. We show that...
<p>To increase the detectability of breast cancer, recent efforts have been made in field grating-based phase-contrast computed tomography, which provides additional information about refractive index decrement introduced by sample. Whereas this signal shows an increased soft-tissue contrast, implementation for polychromatic sources is still tied to higher doses, preventing medical application on patients. To lower dose, we introduce self-supervised deep learning network Noise2Inverse...
<p>To increase the detectability of breast cancer, recent efforts have been made in field grating-based phase-contrast computed tomography, which provides additional information about refractive index decrement introduced by sample. Whereas this signal shows an increased soft-tissue contrast, implementation for polychromatic sources is still tied to higher doses, preventing medical application on patients. To lower dose, we introduce self-supervised deep learning network Noise2Inverse...
Inverse Compton scattering of infrared photons from relativistic electrons generates brilliant quasi-monochromatic X-rays with an electron accelerator dimensions only a few meters, e.g. at the storage ring based inverse X-ray source employed Munich Compact Light Source. Availability synchrotron light in laboratory comes along broader access to techniques, especially - but not limited clinical imaging and pre-clinical biomedical applications. We have been exploring latter daily user operation...
Although the mortality rate of breast cancer has been reduced with introduction screening mammography, many women undergo unnecessary subsequent examinations due to inconclusive diagnoses. Therefore, spatial resolution and soft tissue contrast must meet very high standards. The former is necessary in order be able detect distinguish closely spaced microcalcifications from each other. Thus, a demanded. Superposition anatomical structures especially within dense breasts conjunction inherently...