A5046917995- Advanced X-ray and CT Imaging
- Radiation Dose and Imaging
- Advanced X-ray Imaging Techniques
- Medical Imaging Techniques and Applications
- Protease and Inhibitor Mechanisms
- Peptidase Inhibition and Analysis
- Renal cell carcinoma treatment
- Digital Radiography and Breast Imaging
- Neuroendocrine Tumor Research Advances
- Musculoskeletal pain and rehabilitation
- Medical Imaging and Analysis
- Lymphadenopathy Diagnosis and Analysis
- Advanced Electron Microscopy Techniques and Applications
- Genital Health and Disease
- Advanced MRI Techniques and Applications
- Salivary Gland Tumors Diagnosis and Treatment
- Vascular Procedures and Complications
- Spine and Intervertebral Disc Pathology
- Radiopharmaceutical Chemistry and Applications
- Signaling Pathways in Disease
- Cerebrovascular and Carotid Artery Diseases
- Knee injuries and reconstruction techniques
- Research on Leishmaniasis Studies
- X-ray Spectroscopy and Fluorescence Analysis
- Hemostasis and retained surgical items
Klinikum rechts der Isar
2020-2025
Klinik und Poliklinik für Nuklearmedizin
2025
Technical University of Munich
2017-2024
Ludwig-Maximilians-Universität München
2012-2023
LMU Klinikum
2012-2022
München Klinik
2021
General Electric (Spain)
2016
Our previous study has demonstrated the feasibility of noninvasive imaging fibroblast activation protein (FAP)-expression after myocardial infarction (MI) in MI-territory a rat model with
This study aimed to assess the impact of dedicated cardiac protocol (DCP) on diagnostic accuracy state-of-the-art digital [
Ziel/Aim: Die Diagnose der kardialen Sarkoidose (KS) mittels 18F-FDG-PET erfordert eine gezielte Vorbereitung mit einer mindestens 12-stündigen kohlenhydratarmen, fett- und proteinreichen Diät. Da diese Diät oft nicht vollständig eingehalten wird, kann die Unterscheidung zwischen KS-Granulomen unvollständiger Suppression physiologischen FDG-Aufnahme erschwert sein. Unsere Hypothese lautet, dass regionale Kontraktionsfunktion des Myokards bei KS im Vergleich zu gesundem Myokard deutlich...
Ziel/Aim: [18F]SiTATE is a novel somatostatin receptor-targeting PET-agent with potential clinical advantages based on its F18-label consisting in large batch production, longer half-life and the to be shipped over larger distances. In this retrospective analysis, we investigated whether time between synthesis injection resulting decrease specific activity affects normal organ uptake.
Abstract Current clinical imaging methods face limitations in the detection and correct characterization of different subtypes renal cell carcinoma (RCC), while these are important for therapy prognosis. The present study evaluates potential grating-based X-ray phase-contrast computed tomography (gbPC-CT) visualization human RCC subtypes. results 23 ex vivo formalin-fixed kidney specimens obtained with CT were compared to absorption-based (gbCT), a 3T MRI validated using histology. Regions...
Vascular graft/endograft infection (VGEI) is a serious complication after aortic surgery. This study investigates VGEI and patient characteristics, PET/CT quantification before surgical or conservative management of post-intervention outcomes in order to identify patients who might benefit from such procedure. PET standard uptake values (SUV) were quantitatively assessed compared non-VGEI cohort. The primary endpoints in-hospital mortality reintervention-free survival at six months....
Introduction: Currently, the diagnosis of salivary gland tumors using imaging techniques is unreliable. Methods: In this monocentric retrospective study, we examined patients who received a 68Ga-DOTATOC PET/CT and subsequently underwent tumor resection between 1 January 2010 31 December 2021. image assessment was compared with somatostatin receptor (SSTR) expression histology. Results: Thirteen (five pleomorphic adenoma (PA) eight other parotid lesions (OPL)) PET/CT. Imaging displayed strong...
Background Mesothelial cells are critical in the pathogenesis of post-surgical intraabdominal adhesions as well deterioration peritoneal membrane associated with long-term dialysis. denudation is a pathophysiolocigally important finding these processes. Matrix metalloproteinase (MMP) biology underlies aspects mesothelial homeostasis wound repair. The endogenous tissue inhibitors metalloproteinases (TIMPs) moderate MMP activity. Methods and Finding By modifying human TIMP-1 through addition...
Tissue inhibitors of metalloproteinases exhibit diverse physiological/biological functions including moderation the proteolytic processing growth factors and turnover extracellular matrix. These various biological activities are linked in part to stoichiometry tissue inhibitor metalloprotein/matrix metalloprotein (TIMP/MMP)/surface protein interactions. TIMP-1, a secreted protein, can be detected on cell surface only through its interaction with surface-bound proteins. Proteins anchored by...
Grating-based phase-contrast computed tomography (gb-PCCT) relies on x-ray refraction instead of absorption to generate high-contrast images in biological soft tissue. The aim this study was evaluate the potential gb-PCCT for depiction structural changes heart disease.Four human specimens from patients with hypertensive disease, ischemic dilated and cardiac lipomatosis were examined. setup consisted an tube (40 kV, 70 mA), grating-interferometer, detector, allowed simultaneous acquisition...
Abstract Tissue inhibitor of metalloproteinase 1 (TIMP-1) controls matrix activity through 1:1 stoichiometric binding. Human TIMP-1 fused to a glycosylphosphatidylinositol (GPI) anchor (TIMP-1–GPI) shifts the from extracellular cell surface. TIMP-1–GPI treated renal carcinoma cells show increased apoptosis and reduced proliferation. Transcriptomic profiling regulatory pathway mapping were used identify potential mechanisms driving these effects. Significant changes in DNA binding inhibitors,...
Vaccine-associated lymphadenopathy (VAL) is a common finding on <sup>18</sup>F-FDG PET/CT examinations following Coronavirus disease 2019 (COVID-19) vaccination. However, data regarding VAL <sup>18</sup>F-rhPSMA-7.3-ligand PET are currently lacking. This study assesses its prevalence, temporal response to vaccination and characteristics of VAL. <b>Methods:</b> 233 consecutive vaccinated 41 unvaccinated patients with confirmed prostate cancer who underwent <sup>18</sup>F-rhPSMA-7.3 were...
Multi-frequency processing (MFP) leads to enhanced image quality (IQ) of radiographs. This study is determine the effect third generation MFP (M3) on IQ in comparison standard second-generation (M2). 20 cadavers were examined and post-processing radiographs was performed with both M2 M3. Three readers blinded used for each independently compared corresponding pairs according overall depiction bony structures soft tissue (+ 2: notably better > 0: equal - worse). A significant deviation median...
Abstract The balance between matrix metalloproteinases and their endogenous tissue inhibitors ( TIMP s) is an important component in effective wound healing. biologic action of these proteins linked part to the stoichiometry /matrix metalloproteinases/surface protein interactions. We recently described effect a glycosylphosphatidylinositol GPI ) anchored version ‐1 on dermal fibroblast biology. Here, cell proliferation assays, vitro healing, electrical wound, impedance measurements were used...
Abstract This study investigates the x-ray scattering characteristics of microsphere particles in x-ray-grating-based interferometric imaging at different concentrations, bubble sizes and tube voltages (kV). Attenuation (ATI), dark-field (DFI) phase-contrast (PCI) images were acquired. Signal-to-noise (SNR) contrast-to-noise ratios with water (CNR w ) air as reference a determined. In all modalities, linear relationship between SNR microbubbles concentration, respectively, size was found. A...
Reliable preoperative diagnosis between salivary gland tumor entities is difficult. In this monocentric retrospective study, we examined the somatostatin receptor 2 (SSTR2) status of tumors after resection via immunohistochemistry (IHC), and stains were compared in analogy to HER2 mamma scale. A total 42.3% all pleomorphic adenoma (PA) (42 99, 95% confidence interval 32.5-52.8%) demonstrated ≥20% cells displaying SSTR2 as just 1% other (1/160, CI 0.02-3.4%). The was a neuroendocrine...
The aim of this study was to define optimal tube potential for soft tissue and vessel visualization in dose-reduced chest CT protocols using model-based iterative algorithm average overweight patients.Thirty-six patients receiving according 3 (120 kVp/noise index [NI], 60; 100 kVp/NI, 65; 80 70) were included prospective study, approved by the ethics committee. Patients' physical parameters dose descriptors recorded. Images reconstructed with algorithm. Two radiologists evaluated image...
Background The differentiation of minimal-fat—or low-fat—angiomyolipomas from other renal lesions is clinically challenging in conventional computed tomography. In this work, we have assessed the potential grating-based x-ray phase-contrast tomography (GBPC-CT) for visualization and quantitative minimal-fat angiomyolipomas (mfAMLs) oncocytomas cell carcinomas (RCCs) on ex vivo samples. Materials methods Laboratory GBPC-CT was performed at 40 kVp 28 kidney specimens including five with three...