A5018593677- Respiratory Support and Mechanisms
- Medical Imaging Techniques and Applications
- Radiomics and Machine Learning in Medical Imaging
- Radiopharmaceutical Chemistry and Applications
- Cardiac Arrest and Resuscitation
- Neonatal Respiratory Health Research
- Advanced X-ray and CT Imaging
- Thermal Regulation in Medicine
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Intensive Care Unit Cognitive Disorders
- Lung Cancer Diagnosis and Treatment
- Advanced Radiotherapy Techniques
- Atomic and Subatomic Physics Research
- Asthma and respiratory diseases
- Peptidase Inhibition and Analysis
- Prostate Cancer Treatment and Research
- Hemodynamic Monitoring and Therapy
- Inhalation and Respiratory Drug Delivery
- Electrical and Bioimpedance Tomography
- Advanced MRI Techniques and Applications
- Mechanical Circulatory Support Devices
- Advanced Thermodynamic Systems and Engines
- Model-Driven Software Engineering Techniques
- Advanced Chemical Sensor Technologies
- Ultrasound in Clinical Applications
Klinik und Poliklinik für Nuklearmedizin
2019-2025
Helmholtz-Zentrum Dresden-Rossendorf
2025
University Hospital Carl Gustav Carus
2013-2024
TU Dresden
2014-2024
Dräger (Germany)
2023
Klinik und Poliklinik für Psychotherapie und Psychosomatik
2018
Harvard University
2014-2017
University of Genoa
2017
Merck (Germany)
2017
Universidade Federal do Rio de Janeiro
2017
Objective: Volutrauma and atelectrauma promote ventilator-induced lung injury, but their relative contribution to inflammation in injury is not well established. The aim of this study was determine the impact volutrauma on distribution experimental acute respiratory distress syndrome. Design: Laboratory investigation. Setting: University-hospital research facility. Subjects: Ten pigs (five per group; 34.7–49.9 kg) Interventions: Animals were anesthetized intubated, saline lavage performed....
The analysis aimed to compare the radiotracers [68Ga]-Ga-PSMA-11 and [18F]-F-PSMA-1007 intraindividually in terms of malignant lesions, mi(molecular-imaging)TNM staging presumable unspecific lesions retrospectively as used routine clinical practice.A retrospective 46 prostate cancer patients (median age: 71 years) who underwent consecutive [68Ga]-Ga-PSMA-11- [18F]-F-PSMA-1007-PET/CT or PET/MRI within a mean 12 ± 8.0 days was performed. MiTNM performed both studies by two nuclear medicine...
PET nuclides can have a considerable influence on the spatial resolution and image quality of PET/CT scans, which diagnostics in oncology, for example. The individual impact positron energy 18F, 68Ga, 64Cu was compared scans acquired using clinical, digital scanner.A Jaszczak phantom NEMA body were filled with 18F-FDG, 68Ga-HCl, or 64Cu-HCl, performed Siemens Biograph Vision. Acquired images analyzed regarding (recovery coefficients (RC), coefficient variation within background, contrast...
Abstract Background Residual image noise is substantial in positron emission tomography (PET) and one of the factors limiting lesion detection, quantification, overall quality. Thus, improving reduction remains considerable interest. This especially true for respiratory-gated PET investigations. The only broadly used approach imaging has been application low-pass filters, usually Gaussians, which however leads to loss spatial resolution increased partial volume effects affecting...
Spontaneous breathing (SB) in the early phase of acute respiratory distress syndrome is controversial. Biphasic positive airway pressure/airway pressure release ventilation (BIPAP/APRV) commonly used, but level SB necessary to maximize potential beneficial effects unknown.Experimental was induced by saline lung lavage anesthetized and mechanically ventilated pigs (n = 12). By using a Latin square crossover design, animals were with BIPAP/APRV at four different levels total minute (60 min...
Asymmetry and heterogeneity in the branching of human bronchial tree are well documented, but their effects on bronchoconstriction ventilation distribution asthma unclear. In a series seminal studies, Venegas et al. have shown that may lead to self-organized patterns patchy computational model could explain areas poor [ventilation defects (VDefs)] observed positron emission tomography images during induced bronchoconstriction. To investigate anatomic asymmetry emergence VDefs we used...
To determine the impact of positive end-expiratory pressure during mechanical ventilation with and without spontaneous breathing activity on regional lung inflammation in experimental nonsevere acute respiratory distress syndrome.Laboratory investigation.University hospital research facility.Twenty-four pigs (28.1-58.2 kg).In anesthetized animals, intrapleural sensors were placed thoracoscopically ventral, dorsal, caudal regions left hemithorax. Lung injury was induced saline lavage followed...
Abstract Purpose Convolutional Neural Networks (CNNs) have emerged as transformative tools in the field of radiation oncology, significantly advancing precision contouring practices. However, adaptability these algorithms across diverse scanners, institutions, and imaging protocols remains a considerable obstacle. This study aims to investigate effects incorporating institution-specific datasets into training regimen CNNs assess their generalization ability real-world clinical environments....
PET imaging with <sup>18</sup>F-FDG followed by mathematic modeling of the pulmonary uptake rate (K<sub>i</sub>) is gold standard for assessment inflammation in experimental studies acute respiratory distress syndrome (ARDS). However, dynamic requires long and allows only 1 cranio-caudal field view (∼15 cm). We investigated whether static PET/CT analysis SUV or standardized ratios (SUR<sub>stat</sub>, time–corrected ratio concentration lung tissue blood plasma) might be an alternative to...
To investigate the role of ultraprotective mechanical ventilation (UP-MV) and extracorporeal carbon dioxide removal with without spontaneous breathing (SB) to improve respiratory function lung protection in experimental severe acute distress syndrome.Severe syndrome was induced by saline lavage (MV) higher tidal volume (VT) 28 anesthetized pigs (32.8 52.5 kg). Animals (n = 7 per group) were randomly assigned 6 h MV (airway pressure release ventilation) with: (1) conventional P-MV VT ≈6 ml/kg...
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Background: Mechanical ventilation (MV) may initiate or worsen lung injury, so-called ventilator-induced injury (VILI). Although different mechanisms of VILI have been identified, research mainly focused on single ventilator parameters. The mechanical power (MP) summarizes the potentially damaging effects parameters in one variable and has shown to be associated with damage. However, date, association MP pulmonary neutrophilic inflammation, as assessed by positron-emission tomography (PET),...
Quantitative lung computed tomography (CT) provides fundamental information about aeration in critically ill patients. We tested a scanning protocol combining reduced number of CT slices and tube current, comparing quantitative analysis radiation exposure to conventional CT. In pigs, scans were performed during breath hold model injury with three different protocols: standard spiral 180 mAs current-time product (Spiral180), sequential 20-mm distance between either (Sequential180) or 50...
Vascular graft/endograft infection (VGEI) is a serious complication after aortic surgery. This study investigates VGEI and patient characteristics, PET/CT quantification before surgical or conservative management of post-intervention outcomes in order to identify patients who might benefit from such procedure. PET standard uptake values (SUV) were quantitatively assessed compared non-VGEI cohort. The primary endpoints in-hospital mortality reintervention-free survival at six months....
Abstract Aim 68Ga-PSMA-11 is the gold standard for molecular imaging of prostate cancer. However, recurrent tumor manifestations or metastases cannot be detected in every case. Therefore, we investigated if there an additive value gastrin-releasing peptide receptor (GRP-R) ligand 68Ga-RM2 compared to well-established patients with (Group 1) and without 2) pathologic PSMA-expression different stages. Patients Methods Sixteen men (median age: 74 years, range 50–80 years) cancer stages who had...
Web browsers are promising candidates for the OPC's SOAP-HTTP WS-SC UA XML StackProfile to execute visualization solutions. First tests could demonstrate applicability of native web without any plugins but required cryptographic algorithms cause unacceptable response times. The enormous performance improvement JavaScript engines lets expect an adequate reduction operating times; this may be strengthen by using effective HTTP UA-SC Binary Stack Profile. This paper presents current development...
Background: Computed tomography is the gold standard for lung aeration assessment, but exposure to ionizing radiation limits its application. We assessed ability of magnetic resonance imaging (MRI) detect changes in ex vivo isolated swine and potential translation findings human MRI scans. Methods: performed scans 11 non-injured injured lungs, as well 6 patients both pre- post-operatively. Images were obtained using a 1.5 T scanner, with T1 - weighted volumetric interpolated breath-hold...