A5100422733- Respiratory Support and Mechanisms
- Circular RNAs in diseases
- Natural product bioactivities and synthesis
- Bioinformatics and Genomic Networks
- MicroRNA in disease regulation
- Bioactive Natural Diterpenoids Research
- Cancer-related molecular mechanisms research
- Cancer-related gene regulation
- RNA modifications and cancer
- Extracellular vesicles in disease
- Intensive Care Unit Cognitive Disorders
- Cardiac Arrest and Resuscitation
- Phytochemical compounds biological activities
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Eicosanoids and Hypertension Pharmacology
- Ubiquitin and proteasome pathways
- Genetic and Kidney Cyst Diseases
- Histone Deacetylase Inhibitors Research
- Metabolomics and Mass Spectrometry Studies
- Protein Degradation and Inhibitors
- DNA Repair Mechanisms
- Kruppel-like factors research
- Hippo pathway signaling and YAP/TAZ
- Phytochemistry and Bioactivity Studies
- Medicinal Plant Pharmacodynamics Research
Anhui Normal University
2024
University Hospital Carl Gustav Carus
2021-2024
Soochow University
2018-2024
First Affiliated Hospital of Soochow University
2018-2024
Affiliated Hospital of Southwest Medical University
2018-2024
Chengdu University of Traditional Chinese Medicine
2024
Southwest Medical University
2023
University of Mississippi Medical Center
2023
Xian Yang Central Hospital
2023
Wannan Medical College
2023
Viral myocarditis (VM) is a clinically common inflammatory disease. Accumulating literature has indicated that M2 macrophages protect mice from Coxsackievirus B3 (CVB3)-induced VM. However, mechanisms underlie alleviating myocardial inflammation remain largely undefined. We found macrophage-derived exosomes (M2-Exo) can effectively attenuate The long non-coding RNA (lncRNA) AK083884 in M2-Exo was to be involved the regulation of macrophage polarization by exosome lncRNA sequencing combined...
Thirteen new ent-kaurane diterpenoids, stigmaydenes A–M (1-13), together with two known compounds (14, 15), were isolated from the crude extract of corn silk (Zea mays). The structures confirmed by comprehensive spectroscopic analyses. absolute configuration compound 1 was defined single-crystal X-ray diffraction. configurations also comparison experimental and calculated specific rotations. evaluated for their neuroprotective effects against H2O2-induced SH-SY5Y cell injury, 8 active at 100...
Chromatographic purification of the roots Daphne genkwa led to 11 new guaiane-type sesquiterpenoids (1–11), named genkwanoids A–K, and six known analogues (12–17). A comprehensive set spectroscopic methods including IR, UV, HRESIMS, 1D/2D NMR were used elucidate structures relative configurations 1–11. The absolute determined by optical rotation calculations modified Mosher's method. possible biosynthetic pathways for 1–11 are proposed. Furthermore, neuroprotective effects 1–17 on...
Tctn3 belongs to the Tectonic (Tctn) family and is a single-pass membrane protein localized at transition zone of primary cilia as an important component ciliopathy-related complexes. Previous studies showed that mutations in Tctn1 Tctn2, two members tectonic family, have been reported disrupt neural tube development humans mice, but functions brain remain elusive. In this study, knockout (KO) mice were generated by utilizing piggyBac (PB) transposon system. We found KO exhibited abnormal...
Abstract Aims Diabetic nephropathy (DN) is a leading cause of end‐stage renal disease. BASP1 (brain acid‐soluble protein) up‐regulated in podocyte‐specific protein phosphatase 2A knockout mice (Pod‐PP2A‐KO) that develop kidney dysfunction. Here, we explore the role for podocytes DN. Methods was assessed kidneys from DN patients and mouse models, podocyte specific (Pod‐BASP1‐KO mice) were generated studied vivo. Furthermore, injury apoptosis measured after knockdown overexpression cell line...
Hepatocellular carcinoma (HCC) is a malignant tumour associated with high mortality rate and poor prognosis worldwide. Uridine diphosphate-glucose pyrophosphorylase 2 (UGP2), key enzyme in glycogen biosynthesis, has been reported to be the occurrence development of various cancer types. However, its diagnostic value prognostic HCC remain unclear. The present study observed that UGP2 expression was significantly downregulated at both mRNA protein levels tissues. Receiver operating...
Background: Mechanical ventilation (MV) may initiate or worsen lung injury, so-called ventilator-induced injury (VILI). Although different mechanisms of VILI have been identified, research mainly focused on single ventilator parameters. The mechanical power (MP) summarizes the potentially damaging effects parameters in one variable and has shown to be associated with damage. However, date, association MP pulmonary neutrophilic inflammation, as assessed by positron-emission tomography (PET),...
Intestinal fibrosis is the main pathological process in Crohn’s disease (CD); acupuncture and moxibustion can inhibit of CD rats, but regulatory mechanism remains unknown. The present study observed effect on extracellular signal-regulated kinase (ERK) signaling pathway rat. result shows that phosphorylation Ras, Raf-1, MEK-1, ERK-1/2 proteins expression corresponding mRNAs colon tissue rat were significantly higher than normal control group. Both treatments with mild herb-separated reduced...
Stress hyperglycemia ratio (SHR) can reduce the impact of baseline glucose on stress level. Studies have shown that SHR is associated with adverse outcomes. However, its relationship prognosis trauma/surgical ICU patients has not been fully studied. The objective this study was to explore between and short-term long-term mortality in patients. Clinical data were extracted from MIMIC-IV. primary outcome 28-day all-cause mortality, secondary 365-day mortality. Boruta algorithm used screen...
Background: Circular RNAs (circRNAs) have increasingly been investigated in different cancers due to their regulatory roles. In this study, hsa_circ_0046263 will be detailedly researched non-small cell lung cancer (NSCLC). Methods: The analyses of hsa_circ_0046263, microRNA-940 (miR-940), and neuro-oncological ventral antigen 2 (NOVA2) levels were administrated by quantitative real-time polymerase chain reaction (qRT-PCR). proliferation detection was conducted using Cell Counting Kit-8...
Our study aims to investigate the effect of microRNA-183 (miR-183) on human umbilical vascular endothelial cells (HUVECs) injury by targeting IRS1. HUVECs was induced oxidized low-density lipoprotein (ox-LDL). were grouped so as explore role ox-LDL and miR-183 in injury, with expression IRS1 detected. Additionally, related factors oxidative stress inflammation, well angiogenesis ability, proliferation, cell cycle, apoptosis, invasion, migration abilities also measured. Ox-LDL treatment could...
Abstract The potential biological relationship between type‐2 diabetes mellitus (T2DM) has been focused in numerous studies. To investigate the molecular associations among T2DM, prostate cancer (PCa), and chronic myeloid leukemia (CML), using a biomolecular network enrichment analysis. We obtained list of disease‐related genes constructed disease networks. Then, GO analysis was performed to identify significant functions pathways overlapping modules Database for Annotation, Visualization...
Background: The incidence of hypoxemia during one-lung ventilation (OLV) is as high 10%. It also partially determined by the distribution perfusion. During thoracic surgery, different body positions are used, such supine, semilateral, lateral, and prone positions, with potentially influencing Furthermore, hypovolemia can impair hypoxic vasoconstriction. However, effects position on perfusion remain poorly defined. We hypothesized that, OLV, relative ventilated lung higher in lateral...
Circular RNAs (circRNAs) participate in the genesis and progression of tumors, including non-small cell lung cancer (NSCLC). At present, role regulatory mechanisms circRNAs NSCLC have not been fully elucidated. The aim this study was to explore mechanism circRNA hsa_circ_0008037 (circ_0008037) NSCLC.Expression circ_0008037 tissues cells detected by quantitative real-time polymerase chain reaction (RT-qPCR). Loss-of-function experiments were performed analyze influence knockdown on...
Recent evidence demonstrates that a double dose of Jasminoidin (2·JA) is more effective than (JA) in cerebral ischemia therapy, but its dosage-effect mechanisms are unclear. In this study, the software GeneGo MetaCore was used to perform pathway analysis differentially expressed genes obtained microarrays mice belonging four groups (Sham, Vehicle, JA, and 2·JA), aiming elucidate differences JA 2·JA's dose-dependent pharmacological mechanism from system's perspective. The top 10 enriched...