A5032797705- Phytochemistry and Biological Activities
- Natural product bioactivities and synthesis
- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Phytochemical compounds biological activities
- Traditional and Medicinal Uses of Annonaceae
- Bioactive Natural Diterpenoids Research
- Botanical Studies and Applications
- Phytochemicals and Antioxidant Activities
- Fungal Biology and Applications
- Plant biochemistry and biosynthesis
- Marine Sponges and Natural Products
- Cholinesterase and Neurodegenerative Diseases
- Essential Oils and Antimicrobial Activity
- Phytochemistry and Bioactivity Studies
- Phytochemical Studies and Bioactivities
- Phytochemistry and Bioactive Compounds
- Plant-derived Lignans Synthesis and Bioactivity
- Natural Compounds in Disease Treatment
- Sesquiterpenes and Asteraceae Studies
- Epigenetics and DNA Methylation
- Medicinal plant effects and applications
- Bioactive natural compounds
- melanin and skin pigmentation
- Plant-based Medicinal Research
Shenyang Pharmaceutical University
2016-2025
Yantai University
2023-2025
Renmin Hospital of Wuhan University
2023-2025
First Affiliated Hospital of GuangXi Medical University
2024-2025
Zhejiang Chinese Medical University
2023-2025
Wuhan University
2023-2025
Guangxi Medical University
2024-2025
Fudan University
2025
Zhongshan Hospital
2025
Harbin Institute of Technology
2023-2024
Daphnenoids A–C (1–3), three unusual sesquiterpenes with distinctive ring skeletons, together a biogenetically related daphnenoid D (4) were obtained from the herb of Daphne penicillata by molecular networking strategies. Daphnenoid A (1) possesses unique caged tetracyclo [5.3.2.01,6.04,11] dodecane scaffold unexpected cyclizations C-1/C-11 and C-2/C-14. B C (2 3) first discovered natural 5/5 spirocyclic systems in nature. Their structures determined NMR spectroscopic analysis,...
Prunus tomentosa seeds were researched for antioxidant and anti-inflammatory constituents. By activity-guided fractionation of P. seed extract, six new dihydrobenzofuran neolignans, prunustosanans AI-IV (1–4) prunustosanansides AI AII (5 6), together with 10 known compounds (7–16) isolated from bioactive fraction. The structures determined by spectroscopic analyses, especially NMR, HRESIMS, CD spectra. activity was greatest 5, 10, 12 against DPPH radical 8, 9, 13 ABTS radical. Moreover, 7 11...
During the process of manufacturing hawthorn (Crataegus pinnatifida) juice and jam, a significant quantity byproducts (leaves, seeds) is generated. The antioxidant anti-inflammatory bioassay-guided fractionation extract seeds has led to isolation eight new lignans, hawthornnins A-H (1-8), seven known analogues (9-15). Their structures were elucidated by spectroscopic techniques, including 1D 2D NMR CD spectra. radical-scavenging effects all isolated compounds investigated. 1-6 8 showed...
Thirteen new ent-kaurane diterpenoids, stigmaydenes A–M (1-13), together with two known compounds (14, 15), were isolated from the crude extract of corn silk (Zea mays). The structures confirmed by comprehensive spectroscopic analyses. absolute configuration compound 1 was defined single-crystal X-ray diffraction. configurations also comparison experimental and calculated specific rotations. evaluated for their neuroprotective effects against H2O2-induced SH-SY5Y cell injury, 8 active at 100...
Chromatographic purification of the roots Daphne genkwa led to 11 new guaiane-type sesquiterpenoids (1–11), named genkwanoids A–K, and six known analogues (12–17). A comprehensive set spectroscopic methods including IR, UV, HRESIMS, 1D/2D NMR were used elucidate structures relative configurations 1–11. The absolute determined by optical rotation calculations modified Mosher's method. possible biosynthetic pathways for 1–11 are proposed. Furthermore, neuroprotective effects 1–17 on...
Eleucanainones A and B are two structurally complex naphthoquinone-derived dimers whose structure identification is difficult. Large yellow fragments of the preliminary CASE (computer-assisted elucidation) analysis revealed that original structures might be questionable. Structural revisions compounds were proposed on basis NMR analysis, methods, conformation DFT (density functional theory) calculations with a custom DP4+ analysis. In addition, polyketide-folded biosynthetic pathway revised...
Unprecedented sesquiterpenoid scaffolds, furnished by unexpected carbon–carbon linkage formation or cleavage, were targeted and isolated from Daphne aurantiaca following an integrated strategy.
Stigma maydis (corn silk) (S. maydis) is a food-based by-product of maize and possesses great nutritional pharmaceutical value. This study aimed to explore bioactive components from S. maydis. By the guidance bioactivity-guided approach Global Natural Products Social (GNPS) molecular networking, 12 terpenoids were discovered The structures 11 undescribed compounds (1–11) determined by detailed spectroscopic analyses, single-crystal X-ray diffraction analysis, specific rotation calculations,...
Red raspberry (Rubus idaeus L.) is an edible fruit-producing species belonging to the Rosaceae family. In our search for health-promoting constituents from this fruit, four pairs of enantiomeric phenylpropanoids (1a/1b-4a/4b), including three new compounds (1a and 2a/2b), were isolated red raspberry. Their structures elucidated by a combination extensive NMR spectroscopic data analyses, high-resolution electrospray ionization mass spectrometry comparison between experimental measurements...
Quassinoids are a class of highly oxygenated degraded triterpenoids exclusively discovered from plants the Simaroubaceae family. In this study, eight new (1–8) and 15 known quassinoids (9–23) were isolated an extract stems Picrasma quassioides. The structures elucidated by spectroscopic analysis electronic circular dichroism spectra combined with quantum chemical calculations. Compounds 4 5 represent first examples 18-nor-quassinoids P. All isolates screened for their neuroprotective...
Four enantiomeric pairs of highly modified spirocyclohexenone neolignans, (±)-pinnatifidaones A–D, with a novel 2-oxaspiro[4.5]deca-6-en-8-one motif, were isolated from <italic>Crataegus pinnatifida</italic>.