A5102943519- Traditional and Medicinal Uses of Annonaceae
- Phytochemical compounds biological activities
- Immune Cell Function and Interaction
- Listeria monocytogenes in Food Safety
- Bioactive Natural Diterpenoids Research
- Phytochemistry and Bioactivity Studies
- Phytochemistry and Biological Activities
- interferon and immune responses
- Insect Pest Control Strategies
- Synthesis and bioactivity of alkaloids
- Sesquiterpenes and Asteraceae Studies
- Peptidase Inhibition and Analysis
- Immune Response and Inflammation
- Traditional Chinese Medicine Studies
- T-cell and B-cell Immunology
- Cancer Genomics and Diagnostics
- RNA regulation and disease
- MicroRNA in disease regulation
- Gastric Cancer Management and Outcomes
- Ferroptosis and cancer prognosis
- Whipple's Disease and Interleukins
- Phytochemistry and Bioactive Compounds
- Phytochemical Studies and Bioactivities
- Aquaculture disease management and microbiota
- Bacterial biofilms and quorum sensing
Yunnan University
2023-2025
Heilongjiang University
2024
Fujian Agriculture and Forestry University
2019-2024
Kyoto University
2024
Kyoto University Institute for Chemical Research
2024
Center for Life Sciences
2024
Tongji Hospital
2024
Huazhong University of Science and Technology
2024
Chengdu Medical College
2023
University of Chinese Academy of Sciences
2021
Abstract Teleost fish type I IFNs and the associated receptors from cytokine receptor family B (CRFB) are characterized by remarkable diversity complexity. How bind to their is still not fully understood. In this study, we demonstrate that CRFB1 CRFB5 constitute pair through which subgroup d IFN (IFNd) large yellow croaker, Larimichthys crocea, activates conserved JAK-STAT signaling pathway as a part of antiviral response. Our data suggest L. crocea IFNd (LcIFNd) has higher binding affinity...
Abstract Recurrent urinary tract infections (UTIs) are increasingly associated with antibiotic resistance, posing significant clinical challenges. This study evaluates the antimicrobial efficacy of membrane-intercalating conjugated oligoelectrolyte COE-D8 against uropathogenic Escherichia coli (UPEC). Among 93 UPEC isolates, over 50% demonstrated resistance to first-line antibiotics, compound sulfamethoxazole showing highest (75% at a minimum inhibitory concentration (MIC) >512 μg/mL)....
S-1, an oral multicomponent capsule containing tegafur, gimeracil, and potassium oxonate, has demonstrated efficacy in various tumor types. This study aimed to assess the pharmacokinetics, bioequivalence (BE), safety of a newly developed generic S-1 compared original brand-name formulation Chinese cancer patients under fasting fed conditions. A multicenter, randomized, open-label, single-dose, double-cycle crossover was conducted patients. The involved 120 subjects, with 60 assigned group...
BACKGROUND Depression is a disease with significant global social burden. Single nucleotide polymorphisms (SNPs) are correlated the development of depression. This study investigates relationship between in GPHN and ATP6V1D gene promoter regions susceptibility to depression Chinese population. AIM To provide new insights into identifying SNPs for predicting METHODS We conducted case-control involving 555 individuals 509 healthy controls. rs8020095 rs3759755, rs10144417, rs2031564, rs8016024...
Abstract In mammals, type I IFNs, which commonly contain one or two disulfide bonds, activate the JAK-STAT signaling pathway through binding to common cell surface receptor formed by IFN-α/β (IFNAR)1 and IFNAR2 subunits. Although IFNs are also known be essential for antiviral defense in teleost fish, very little is about mechanisms underlying recognition of fish associated receptors. this study, we demonstrate that a IFN large yellow croaker Larimichthys crocea (LcIFNi), belonging new...
Population heterogeneity is an important component of the survival mechanism Listeria monocytogenes, leading to cells in a population with diverse stress resistance levels. We previously demonstrated that several ribosomal gene rpsU mutations enhanced L. monocytogenes and lowered growth rate at 30 °C lower temperatures. This study investigated whether these switches phenotypes could result bias strain detection when standard enrichment-based procedures are applied variety strains. Detailed...
Four pairs of β-carboline enantiomers (1A: /1B: -4A: /4B: ), 2 derivatives (5: - 6: ) with a single enantiomeric configuration, together known achiral congeners (7: 8: were isolated from the stems Picrasma quassioides. Their structures elucidated on basis extensive spectroscopic analyses and quantum mechanical calculations. Compound 5: possesses 4,5-seco framework represents first example this type alkaloids nature. A possible biosynthetic pathway is proposed to generate racemate 4:...
Microbial multispecies communities consisting of background microbiota and Listeria monocytogenes could be established on materials used in food processing environments. The presence, abundance diversity the strains within these microbial may affected by mutual interactions differences resistance towards regular cleaning disinfection (C&D) procedures. Therefore, this study aimed to characterize growth a L. strain cocktail (n = 6) during biofilm formation polyvinyl chloride (PVC) stainless...
Abstract The pan-genome consists of core genes shared by all members a taxonomy and accessory found in only subset, holding the keys to advancing our understanding evolution tackling medical challenges. Here, we discovered strong intra-genomic correlation among bacterial within each Escherichia coli , Listeria monocytogenes Staphylococcus aureus Campylobacter jejuni . With convolutional neural network assisted genome knock-out simulation, that different combinations fewer than 20 highly...
Chemical investigation of 75% EtOH exact the root bark Ailanthus altissima (Mill.) Swingle led to isolation and identification two new phenylpropanoids (1–2), along with six known compounds (3–8). Their chemical structures were elucidated by extensive spectroscopic data analyses including NMR experiments HRESIMS analyses, as well computer-assisted structure elucidation software (ACD/Spectrus Processor). All evaluated for cytotoxic activities against Hep 3B G2 cells. Compound 1 7 displayed...
Summary of main observation and conclusion Genkwadane F—I ( 1 — 4 ), four new diterpenes, along with known ones 5 8 were isolated from the flower buds D. genkwa . The structures including absolute configurations determined based on analysis NMR ECD calculations. All compounds evaluated for their cytotoxicities against MCF‐7 Hep3B cell lines, among which 3 showed significant activities. Compound exhibited most potent activity IC 50 values 1.33 μM MCF‐7, compound 5.54 8.73 μM, respectively....
Histone methylation is dynamically regulated to shape the epigenome and adjust central nuclear processes including transcription, cell cycle control DNA repair. Lysine-specific histone demethylase 2 (LSD2) has been implicated in multiple types of human cancers. However, its functions remain poorly understood. This study investigated LSD2 homolog AMX-1 C . elegans uncovered a potential link between H3K4me2 modulation interstrand crosslink (ICL) mainly localizes embryonic cells, mitotic gut...
Abstract Sputnik virophages are small double-stranded DNA (dsDNA) viruses that replicate only inside host amoebae infected with giant dsDNA viruses, mimiviruses. infection affects mimivirus replication, but their molecular interaction remains poorly understood. Here, we performed a time-course transcriptome analysis of Acanthamoeba castellanii cells polyphaga (APMV) (hereafter referred to as − cells) and those both APMV 3 virophage (Sputnik + cells). The gene expression patterns the were...
Vascular smooth muscle cell (VSMC) ferroptosis is a pivotal event in the process of aortic dissection (AD), and number agents have protective role against AD by inhibiting VSMC ferroptosis. While glycolysis an ancient pathway related to almost all biological processes, its precise involvement remains unclear.
ABSTRACT Sugar beet ( Beta vulgaris L.) is the main source of white sugar in northern China, and an optimal harvesting time key for maximising its yield content. The goal this study was to investigate effect gradually extending harvest times on growth, physiological characteristics, sucrose accumulation identify time. We conducted a 3‐year experiment across different from 23 Sep 28 Oct (harvest every 7 days) examine effects magnitudes temperature reduction. content were highest III (the...