A5100373460- Coronary Interventions and Diagnostics
- Acute Myocardial Infarction Research
- Cardiac Imaging and Diagnostics
- Cardiovascular Function and Risk Factors
- Lipoproteins and Cardiovascular Health
- Vascular Procedures and Complications
- Antiplatelet Therapy and Cardiovascular Diseases
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Cardiac Valve Diseases and Treatments
- Inflammatory Biomarkers in Disease Prognosis
- Venous Thromboembolism Diagnosis and Management
- Traditional Chinese Medicine Analysis
- Cardiovascular Disease and Adiposity
- Health disparities and outcomes
- Epigenetics and DNA Methylation
- Diabetes Management and Research
- Cancer-related gene regulation
- Cerebrovascular and Carotid Artery Diseases
- Phytochemistry and Biological Activities
- Cancer, Lipids, and Metabolism
- Gut microbiota and health
- Atherosclerosis and Cardiovascular Diseases
- RNA Interference and Gene Delivery
- Intergenerational Family Dynamics and Caregiving
Capital Medical University
2015-2025
Beijing Anzhen Hospital
2016-2025
Heilongjiang University of Chinese Medicine
2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2022-2025
The University of Sydney
2020-2024
Shenyang Pharmaceutical University
2015-2024
Jilin University
2024
Institute of Process Engineering
2024
Nanjing Tech University
2020-2024
Sun Yat-sen University
2020-2024
The systemic inflammatory response index (SIRI) is a novel biomarker in many diseases.The aim of this study was to examine the association between SIRI and adverse events patients with acute coronary syndrome (ACS) undergoing percutaneous intervention.A total 1724 ACS enrolled from June 2016 November 2017 at single centre were included study, calculated for each patient. primary endpoint composite major cardiovascular (MACE), including overall death, non-fatal myocardial infarction, stroke,...
More recently, evidence showed that the novel anti-inflammatory cytokine interleukin- (IL-) 37 was expressed in foam-like cells of atherosclerotic coronary and carotid artery plaques, suggesting IL-37 is involved atherosclerosis-related diseases. However, plasma levels patients with acute syndrome (ACS, including unstable angina pectoris myocardial infarction) have yet to be investigated.Plasma IL-37, IL-18, IL-18BP were measured 50 stable (SAP), 75 (UAP), 67 infarction (AMI), 65 control...
Radiotherapy-resistant glioblastoma (rrGBM) remains a significant clinical challenge because of high infiltrative growth characterized by activation antiapoptotic signal transduction. Herein, we describe an efficiently biodegradable selenium-engineered mesoporous silica nanocapsule, initiated high-energy X-ray irradiation and employed for at-site RNA interference (RNAi) to inhibit rrGBM invasion achieve maximum therapeutic benefit. Our radiation-triggered RNAi nanocapsule showed...
Abstract Enhancer of zeste homolog 2 ( EZH 2) has been characterized as a critical oncogene and promising drug target in human malignant tumors. The current inhibitors strongly suppress the enhanced enzymatic function mutant some lymphomas. However, recent identification PRC 2‐ methyltransferase‐independent role indicates that complete suppression all oncogenic functions is needed. Here, we report unique 2‐targeting strategy by identifying gambogenic acid GNA ) derivative novel agent...
Herein, we explored an unprecedented mild, nonirritating, conveniently available, and recyclable coupling reagent NDTP, which could activate the carboxylic acids via acyl thiocyanide enable rapid amide peptide synthesis at very mild conditions. In addition, methodology was compatible with Fmoc-SPPS, may provide alternative to manufacturing.
Abstract Background Heterozygous familial hypercholesterolemia (HeFH) is largely underdiagnosed and undertreated in China where few patients achieved recommended target levels of low density lipoprotein cholesterol (LDL-C). We conducted the first randomized, placebo-controlled clinical trial Chinese with HeFH to assess efficacy safety tafolecimab, a novel fully human proprotein convertase subtilisin/kexin type 9 (PCSK9) monoclonal antibody. Methods Patients diagnosed by Simon Broome criteria...
Large Language Models (LLMs), including GPT-x and LLaMA2, have achieved remarkable performance in multiple Natural Processing (NLP) tasks. Under the premise that protein sequences constitute language, Protein (ProLLMs) trained on corpora excel at de novo sequence generation. However, as of now, unlike LLMs NLP, no ProLLM is capable tasks (PLP) field. This prompts us to delineate inherent limitations current ProLLMs: (i) lack natural language capabilities, (ii) insufficient instruction...
Background Transradial coronary intervention has been widely used because of its effects in lowering the incidence complications vascular access site and improving patient satisfaction compared to femoral approach. This study aimed investigate safety feasibility transradial approach for primary percutaneous (PCI) elderly patients with acute myocardial infarction (AMI). Methods A total 103 consecutive (age ≥65 years) who were diagnosed as having AMI indicated PCI. Among them, 57 received PCI...
Interleukin (IL)-37 is a newly discovered member of the cytokine IL-1 family. Recent evidence suggests that IL-37, an anti-inflammatory factor, may have role in atherosclerosis. In this study we used apoE-deficient diabetic mice, established animal model, to examine effects IL-37 on progression vascular calcification and Compared with control groups, IL-37-treated (with injection recombinant protein for 16 weeks) animals had significantly less areas detected by both von Kossa Alizarin Red...
Intestinal neutrophil recruitment is a characteristic feature of the earliest stages inflammatory bowel disease (IBD). Neutrophil elastase (NE) and myeloperoxidase (MPO) mediate formation extracellular traps (NETs); NETs produce bactericidal oxidant hypochlorous acid (HOCl), causing host tissue damage when unregulated. The project aim was to investigate relationship between NET clinical IBD in humans.Human intestinal biopsies were collected from Crohn's (CD) patients, endoscopically...
Curcuma wenyujin is the source plant of three traditional Chinese medicines, which have been widely used in clinical treatment over 1000 years. The content terpenes, major medicinal active ingredients, relatively low this plant. Studies shown that MeJA can promote terpenes biosynthesis plants. However, mechanism underlying effect C . remains unclear. In work, transcriptome leaves with was analyzed to elucidate regulation MeJA-mediated terpene biosynthesis. Based on RNA-seq data, 7,246...
Cardiovascular disease remains the leading cause of mortality in women, yet it has not raised awareness from public. The pathogenesis cardiovascular differs significantly between females and males concerning effect sex hormones. Estrogen progestogen impact system through genomic non-genomic effects. Before menopause, protective effects estrogens have been well described. Progestogens were often used combination with hormone therapy. Fluctuations levels, particularly estrogen deficiency,...
The prognostic value of triglyceride-glucose (TyG) has been well described in patients with coronary artery disease (CAD). Hyperhomocysteinemia (HHcy) promotes insulin resistance and also regarded as a potential risk factor for cardiovascular disease. However, the TyG acute syndrome (ACS) undergoing percutaneous intervention (PCI) interaction between HHcy remain unclear. A total 1,734 ACS PCI were continuously enrolled June 2016 November 2017 at Beijing Anzhen Hospital. Patients categorized...
Introduction Constipation is a common gastrointestinal disorder that can affect quality of life. Probiotics have garnered substantial attention for their potential to alleviate constipation. This study investigates the preventive effects Bifidobacterium animalis subsp. lactis TG11 on loperamide-induced constipation in mice. Methods Mice were randomly assigned normal control (NC), model (CM), and low, medium, high-dose treatment groups (LG, MG, HG). From days 1–14, LG, HG received 10 6 , 7 8...
The Ediacaran Dengying Formation in the Sichuan Basin exhibits well-developed microbial mound–shoal complex (MMSC) sedimentation. Its abundant outcrops, core samples, and thin section data provide advantageous conditions for sedimentary architecture studies. Based on these data, this study elucidates typical lithofacies, identifies architectural elements, summarizes MMSC stacking styles, describes evolution characteristics, explores controlling factors of different styles reservoir...
This study aims to comprehensively analyze the material basis of toad visceral oil(hereafter referred as oil), and explore pharmacological effect oil on atopic dermatitis(AD). Ultra-high performance liquid chromatography-linear ion trap/orbitrap high-resolution mass spectrometry(UHPLC-LTQ-Orbitrap-MS) gas chromatography-mass spectrometry(GC-MS) were employed identify chemical components in oil. The animal model AD was prepared by hapten stimulation method. modeled animals respectively...
Abstract. Precise continuous measurements of relative humidity (RH) vertical profiles in the troposphere have emerged as a considerable scientific issue. In recent years, combination diverse ground-based remote sensing devices has effectively facilitated RH profiling, leading to enhancements spatial resolution and, certain instances, measurement accuracy. This work introduces newly developed approach for obtaining by integrating data from Raman lidar, microwave radiometer, and satellite...
Background Cardiovascular disease and insulin resistance are closely related. The triglyceride-glucose (TyG) index is frequently used as an indicator of resistance. However, there scant information on the TyG in prediabetic population, nor prognostic significance known for prediabetes acute coronary syndrome (ACS) patients. Methods clinical endpoint was a major adverse cardiovascular cerebrovascular event (MACCEs), including cardiac-related death, non-fatal myocardial infarction,...