A5066017268- Nanoplatforms for cancer theranostics
- Nanoparticle-Based Drug Delivery
- RNA Interference and Gene Delivery
- Cancer-related molecular mechanisms research
- MicroRNA in disease regulation
- Immune cells in cancer
- Aerogels and thermal insulation
- Extracellular vesicles in disease
- Advanced Nanomaterials in Catalysis
- Ear Surgery and Otitis Media
- Ferroptosis and cancer prognosis
- Advanced Photocatalysis Techniques
- Luminescence and Fluorescent Materials
- Spinal Fractures and Fixation Techniques
- Radiation Dose and Imaging
- ATP Synthase and ATPases Research
- Vestibular and auditory disorders
- Advanced biosensing and bioanalysis techniques
- Facial Nerve Paralysis Treatment and Research
- Glioma Diagnosis and Treatment
- Inflammasome and immune disorders
- Ultrasound Imaging and Elastography
- Photodynamic Therapy Research Studies
- Immune Response and Inflammation
- Heat shock proteins research
Nanjing Medical University
2020-2025
Nanjing Brain Hospital
2020-2025
Harbin Institute of Technology
2010-2025
Guilin University of Technology
2024
First Affiliated Hospital of GuangXi Medical University
2017-2023
Guangxi Medical University
2017-2023
Nanjing Tech University
2016-2019
Human glioblastoma (GBM), the most aggressive brain tumor, comprises six major subtypes of malignant cells, giving rise to both inter-patient and intra-tumor heterogeneity. The interaction between different tumor non-malignant cells collectively shape a microenvironment has not been systematically characterized. Herein, we sampled cellular milieu surgically resected primary tumors from 7 GBM patients using single-cell transcriptome sequencing. A lineage relationship analysis revealed that...
Radiotherapy-resistant glioblastoma (rrGBM) remains a significant clinical challenge because of high infiltrative growth characterized by activation antiapoptotic signal transduction. Herein, we describe an efficiently biodegradable selenium-engineered mesoporous silica nanocapsule, initiated high-energy X-ray irradiation and employed for at-site RNA interference (RNAi) to inhibit rrGBM invasion achieve maximum therapeutic benefit. Our radiation-triggered RNAi nanocapsule showed...
By overcoming drug resistance and subsequently enhancing the treatment, combination therapy of photodynamic (PDT) chemotherapy has promising potential for cancer treatment. However, major challenge is how to establish an advanced nanoplatform that can be efficiently guided tumor sites then stably release both drugs a photosensitizer simultaneously precisely. In this study, which considered possibility targeting efficiency magnetic strategy, novel Fe3O4@mSiO2(DOX)@HSA(Ce6) was successfully...
Contact lens sensors provide a noninvasive approach for intraocular pressure (IOP) monitoring in patients with glaucoma. Accurate measurement of this imperceptible variation requires highly sensitive the absence simultaneously amplifying IOP signal and blinking-induced noise. However, current noise-reduction methods rely on external filter circuits, which thicken contact lenses reduce quality. Here, we introduce strain sensor an anti-jamming ability by utilizing self-lubricating layer to...
Existing multimodal sentiment analysis models are effective at capturing commonalities across different modalities and discerning emotions. However, these still face significant challenges when analyzing samples with polarity differences modalities. Neural networks struggle to process such divergent samples, particularly they scarce within datasets. While larger datasets could help address this limitation, collecting annotating them is resource-intensive. To overcome challenge, we propose...
The gully region of the Loess Plateau is among most ecologically fragile areas in China, where rapid urbanization and unique geographical characteristics have intensified territorial spatial conflicts. Characterizing evolution factors driving these conflicts crucial for promoting sustainable development region. This study utilizes land use remote sensing data from 1990, 2000, 2010, 2020 to examine Qingyang City, Gansu Province. A transfer probability matrix a comprehensive conflict index...
Radiotherapy (RT) has been the standard-of-care treatment for patients with glioblastoma (GBM); however, clinical effectiveness is hindered by therapeutic resistance. Here, we demonstrated that tumor immune microenvironment (TIME) exhibited immunosuppressive properties and high expression of Golgi phosphoprotein 3 like (GOLPH3L) in RT-resistant GBM. Our study showed GOLPH3L interacted stimulator interferon genes (STING) at aspartic acid residue 184 after RT, leading to coat protein complex...
Abstract Although RNA interference (RNAi) therapy has emerged as a potential tool in cancer therapeutics, the application of RNAi to glioblastoma (GBM) remains hurdle. Herein, improve therapeutic effect on GBM, cell membrane (CCM)-disguised hypoxia-triggered nanomedicine was developed for short interfering (siRNA) delivery sensitize cells chemotherapy and radiotherapy. Our synthesized CCM-disguised showed prolonged blood circulation, high BBB transcytosis specific accumulation GBM sites via...
Astaxanthin (ATX) is a carotenoid that exerts strong anti-oxidant and anti-inflammatory property deriving from its highly unsaturated molecular structures. However, the low stability solubility of ATX results in poor bioavailability, which markedly hampers application as therapeutic agent clinic advancement. This study investigated promising way transferrin conjugated to poly (ethylene glycol) (PEG)-encapsulated nanoparticles (ATX-NPs) on targeted delivery evaluated possible mechanism...
Stable long-wavelength emission carbon dots (R-CDs) have been synthesized to enable effectively visualize deep brain glioblastoma (GBM) by a liposome-formulated delivery system.
Background: Gliomas are the most refractory intracranial disease characterized by high incidence and mortality rates. Therefore, radiotherapy plays a crucial role in treatment of gliomas. However, recent evidence reveals that ferroptosis is highly associated with radiosensitivity tumor cells. this study aimed to investigate radiosensitivity- ferroptosis-associated biomarkers. Moreover, provide new strategies for evaluation prognosis Methods: The mRNA sequencing relevant clinical data were...
Due to the unique chemical properties of metronidazoles under hypoxic conditions, RDPP(Met) liposomes were found promote release TMZ and siMGMT in cells have strong radiosensitivity for GBM.
M2-like tumor-associated macrophages (TAMs) promote the malignant progression of glioblastomas. However, mechanisms responsible for this phenomenon remain unclear.
Understanding the anatomical variations in human cochlea is important for cochlear implants. This study examined these using a reconstructed fusion model of skull and temporal bone. The three-dimensional (3D) digital bone was from multiple axial micro-computed tomography (CT) scans high resolution CT 15 cadavers. A merged with 3D relationship between skull's mid-sagittal plane analyzed. α β angles autogenous rotation bottom position, respectively, further subdivided spatial orientation. base...
Paclitaxel (PTX) modified superparamagnetic Fe<sub>3</sub>O<sub>4</sub> nanoparticles (Fe<sub>3</sub>O<sub>4</sub>/PTX NPs) are obtained and then Fe<sub>3</sub>O<sub>4</sub>/PTX NPs loaded into human serum albumin (HSA) to form novel Fe<sub>3</sub>O<sub>4</sub>/PTX/HSA with pie structure by self-assembly method.
Background and Purpose. Although chemodynamic therapy (CDT) is promising for cancer treatment, its clinical application still limited because of unresolved issues. In this study, an efficient CDT agent synergistic chemo/CDT mediated by the photothermal effect was developed iron oxide self-assembly method. Methods. Superparamagnetic nanoclusters (SPIOCs) were located within core, which resulted in high conversion outstanding generation reactive oxygen species (ROS). The shell consisted a...
Radiotherapy is an effective treatment for local solid tumors, but the mechanism of damage to human body caused by radiation therapy needs further study. In this study, gene expression profiles peripheral blood samples exposed different doses and rates ionizing (IR) were used bioinformatics analysis investigate IR radiation-induced bystander effect (RIBE). Differentially expressed genes analysis, weighted correlation network functional enrichment hypergeometric test, set variation applied...
Background: For patients with posterior semicircular canal (PSC) BPPV, Epley re-position maneuver and some improvement methods are the most efficient treatment methods. But there were still 9.43% who not benefit from maneuver.Objective: To measure angles of canals evaluate its effect on maneuver.Methods: Fifteen skull specimens, containing 30 temporal bone specimens included. After Micro-CT scanning, 3D reconstruction was loaded CT image. The between each standard plane measured....