A5100373463- Glioma Diagnosis and Treatment
- Immune cells in cancer
- Coronary Interventions and Diagnostics
- Adipokines, Inflammation, and Metabolic Diseases
- Vascular Procedures and Complications
- Meningioma and schwannoma management
- Adenosine and Purinergic Signaling
- Endometrial and Cervical Cancer Treatments
- Ferroptosis and cancer prognosis
- Peripheral Artery Disease Management
- GABA and Rice Research
- Neurofibromatosis and Schwannoma Cases
- RNA modifications and cancer
- Immunotherapy and Immune Responses
- Neuroscience and Neural Engineering
- Chronic Disease Management Strategies
- CAR-T cell therapy research
- Galectins and Cancer Biology
- Orthopedic Surgery and Rehabilitation
- Antimicrobial Peptides and Activities
- Neuroinflammation and Neurodegeneration Mechanisms
- Cardiac Valve Diseases and Treatments
- Microtubule and mitosis dynamics
- Nanoplatforms for cancer theranostics
- Vascular Malformations Diagnosis and Treatment
Chinese Academy of Medical Sciences & Peking Union Medical College
2025
Sun Yat-sen University
2021-2024
Southern Medical University
2024
PLA Academy of Military Science
2022-2024
Shanghai Institute of Optics and Fine Mechanics
2024
Shenzhen University
2024
Changchun University of Chinese Medicine
2024
University of Chinese Academy of Sciences
2024
Nanfang Hospital
2024
South China University of Technology
2024
Abstract Background Sustained yet intractable immunosuppression is commonly observed in septic patients, resulting aggravated clinical outcomes. However, due to the substantial heterogeneity within precise indicators deciphering trajectories and immunological alterations for patients remain largely lacking. Methods We adopted cross-species, single-cell RNA sequencing (scRNA-seq) analysis based on two published datasets containing circulating immune cell profile of as well atlas murine model...
Significance Overnutrition leads to metabolic disorders including obesity and diabetes. Studies have shown that enhanced inflammation is an essential player in the progression of diseases. However, how immune cells sense nutritional status contribute whole-body metabolism are largely unknown. Protein O -linked β- N -acetylglucosamine ( -GlcNAc) modification thought be a sensor modulates cell signaling. Here, we show overnutrition stimulates -GlcNAc signaling macrophages. suppresses...
Abstract Aims Glioblastoma is the most frequent and aggressive primary brain tumor, characterized by rapid disease course poor treatment responsiveness. The abundance of immunosuppressive macrophages in glioblastoma challenges efficacy novel immunotherapy. Methods Bulk RNA‐seq single‐cell glioma patients from public databases were comprehensively analyzed to illustrate macrophage infiltration patterns molecular characteristics podoplanin (PDPN). Multiplexed fluorescence immunohistochemistry...
Abstract Aims Polypoid giant cancer cells (PGCCs) represent a unique subgroup of stem‐like cells, acting as critical factor in promoting the recurrence various solid tumors. The effect PGCCs on tumor malignancy glioma and its immune microenvironment remains unclear. Methods Bioinformatic analysis was performed to investigate relationship between M2 tumor‐associated macrophages (TAMs) infiltration survival glioblastoma (GBM) patients. spatial location TAMs GBM also investigated using Ivy...
Radiation-induced brain injury (RIBI) is a debilitating sequela after cranial radiotherapy. Research on the topic of RIBI has gradually entered public eye, with more innovations and applications evidence-based research biological mechanism in field that. This was first bibliometric analysis RIBI, assessing related to radiation articles that were published during 1998–2023, provide an emerging theoretical basis for future development RIBI. Literature obtained from Web Science Core Collection...
Tumor electric fields therapy (TTFields) is emerging as a novel anti-cancer physiotherapy. Despite recent breakthroughs of TTFields in glioma treatment, the average survival time for glioblastoma patients with <2 years, even when used conjugation traditional therapies. To optimize TTFields-afforded efficacy against glioblastoma, we investigated cancer cell-killing effects various paradigms using vitro and vivo models glioblastoma.For studies, U251 cell line or primary cultures prepared from...
Recent evidence demonstrated that the circulating adipokines were associated with onset of acute coronary syndrome (ACS) including unstable angina pectoris (UAP) and myocardial infarction (AMI). As a novel adipokine, chemerin has been related to atherosclerosis presence artery disease. However, plasma levels in patients ACS have yet be investigated. Plasma adiponectin measured by an enzyme-linked immunosorbent assay (ELISA) 60 stable (SAP), UAP, AMI 40 control patients. Left ventricular...
To evaluate the efficacy and safety of laparoscopic radical hysterectomy (LRH) combined with pelvic lymph node dissection (PLND) in patients early-stage cervical cancer. This retrospective study analyzed 58 cases early cancer who underwent surgical treatment at Western Theater Command General Hospital between January 2019 September 2020. Patients were divided into two groups based on approach: observation group (n=26) received LRH PLND without uterine manipulator, while control (n=32)...
Transradial approach, which is now widely used in coronary angiography and intervention, may be advantageous with respect to the femoral access due lower incidence of vascular complications. Transulnar approach has been proposed for elective procedures patients not suitable transradial approach. The objective this study was evaluate safety efficacy transulnar versus intervention.Two hundred forty undergoing angiography, followed or by were randomized (TUA) (TRA). Doppler ultrasound...
Valsartan has a protective effect against hypertension and atherosclerosis in humans experimental animal models. This study aimed to determine the of prolonged treatment with angiotensin II (Ang II) on valsartan activity CD4(+) T lymphocyte subsets. The results showed that (8 wks) exogenous Ang resulted an increased atherosclerotic plaque size switch stable-to-unstable via modulating activity, including increase helper cell type 1 (Th1) Th17 cells decrease Th2 regulatory (Treg) cells. In...
Abstract Objective To develop and validate an index to quantify the multimorbidity burden in Chinese middle-aged older community-dwelling individuals. Methods We included 20,035 individuals aged 45 from China Health Retirement Longitudinal Study (CHARLS) 19,297 65 Healthy Longevity Survey (CLHLS). outcomes of physical functioning (PF), basic instrumental activities daily living (ADL IADL) mortality were obtained. Based on self-reported disease status, we calculated five commonly used western...
Purinergic ligand-gated ion channel 7 receptor (P2X7R) is an ATP-gated cationic channel. It plays important role in central nervous system diseases such as cerebral hemorrhage and Parkinson's disease, closely related to neuroinflammatory reactions associated with disease progression. In the present study, we evaluated of P2X7R neuroinflammation brain edema after traumatic injury (TBI). We also investigated mechanisms potential therapeutic drugs. vivo experiments, C57BL/6 mice were randomly...
In this study, oleogels were prepared from zein-tea saponin complex nanoparticles (ZTCNP)-stabilized Pickering emulsions template and evaluated their potential as animal fat replacers for application in the beef burger. We utilized tea (TS) to enhance water solubility of zein, then soluble ZTCNP involved hydrogen-bonding interactions fabricated by means microfluidization. The addition TS (0∼7.5 mM) tuned near-neutral wettability increased zein adsorption at oil-water interface, which...
Abstract Background Glioblastoma multiforme (GBM) is the most aggressive primary brain malignancy. Novel therapeutic modalities like tumor electric field therapy (TEFT) have shown promise, but underlying mechanisms remain unclear. The extracellular matrix (ECM) implicated in GBM progression, warranting investigation into TEFT‐ECM interplay. Methods T98G cells were treated with TEFT (200 kHz, 2.2 V/m) for 72 h. Collagen type VI alpha 1 (COL6A1) was identified as hub gene via comprehensive...
Anti-angiotherapy (Bevacizumab) is currently regarded as a promising option for glioma patients who are resistant to temozolomide (TMZ) treatment. But ongoing clinical research failed meet therapeutic expectations. This study aimed explore the pivotal genetic feature responsible TMZ and Bevacizumab resistance in patients.We downloaded transcriptomic methylation data of from The Cancer Genome Atlas (TCGA), Chinese Glioma (CGGA), Gene Expression Omnibus (GEO) databases grouped these into...
Background: Glioma is globally recognised as one of the most frequently occurring primary malignant brain tumours, making identification glioma biomarkers critically significant. The protein KIF18A (Kinesin Family Member 18A) a member kinesin superfamily microtubule-associated molecular motors and has been shown to participate in cell cycle mitotic metaphase anaphase. This first investigation into expression its prognostic value, potential biological functions, effects on immune system...
Despite tremendous progress made in the diagnosis and managements, head neck squamous cell carcinoma (HNSC) remains a global medical dilemma with dismal clinical prognosis high mortality. Gene NT5E encodes ecto-5’-nucleotidase (CD73), which facilitates formation of immunosuppressive tumor microenvironment (TME) permissive for progression various malignancies. Nevertheless, subsets expressed on potential function TME HNSC remain virgin lands HNSC. In this study, we comprehensively performed...
Background: Ecto-5′-nucleotidase (NT5E) encodes the cluster of differentiation 73 (CD73), whose overexpression contributes to formation immunosuppressive tumor microenvironment and is related exacerbated prognosis, increased risk metastasis resistance immunotherapy various tumors. However, prognostic significance NT5E in pan-cancer obscure so far. Methods: We explored expression level cancers adjacent tissues revealed relationship between clinical outcomes by utilizing UCSC Xena database....