A5089965877- Genomics and Phylogenetic Studies
- Protein Structure and Dynamics
- Microbial Natural Products and Biosynthesis
- Protein Hydrolysis and Bioactive Peptides
- RNA Interference and Gene Delivery
- RNA and protein synthesis mechanisms
- Cryptography and Data Security
- Virus-based gene therapy research
- Respiratory Support and Mechanisms
- Intracranial Aneurysms: Treatment and Complications
- Phagocytosis and Immune Regulation
- Consumer Behavior in Brand Consumption and Identification
- Seed and Plant Biochemistry
- Sleep and Work-Related Fatigue
- Fungal Biology and Applications
- Chaos-based Image/Signal Encryption
- Algorithms and Data Compression
- Tuberculosis Research and Epidemiology
- Biochemical effects in animals
- Machine Learning in Bioinformatics
- Media Influence and Health
- Molecular Biology Techniques and Applications
- Topology Optimization in Engineering
- Obstructive Sleep Apnea Research
- Contact Mechanics and Variational Inequalities
University of South China
2024-2025
Nankai University
2013-2025
Nanjing University
2011-2025
Nanjing General Hospital of Nanjing Military Command
2017-2025
Shanghai Tenth People's Hospital
2025
Tongji University
2025
Wuhan University
2025
Renmin Hospital of Wuhan University
2025
Sichuan Agricultural University
2025
Nanjing Medical University
2024
The identification of protein-ligand binding sites is critical to protein function annotation and drug discovery. consensus algorithm COACH developed by us represents one the most efficient approaches prediction. One commonly seen issues with prediction are low quality predicted ligand-binding poses, which usually have severe steric clashes structure. Here, we present COACH-D, an enhanced version utilizing molecular docking refine poses. input COACH-D server amino acid sequence or...
Abstract Motivation Almost all protein residue contact prediction methods rely on the availability of deep multiple sequence alignments (MSAs). However, many proteins from poorly populated families do not have sufficient number homologs in conventional UniProt database. Here we aim to solve this issue by exploring rich data metagenome sequencing projects. Results Based improved MSA constructed data, developed MapPred, a new learning-based method. MapPred consists two component methods,...
Abstract Sleep apnea syndrome (SAS) is a disorder in which respiratory airflow frequently stops during sleep. Alterations electroencephalogram (EEG) signal are one of the physiological changes that occur apnea, and can be used to diagnose monitor sleep events. Herein, we proposed method automatically distinguish events using characteristics EEG signals order categorize obstructive (OSA) events, central (CSA) normal breathing Through use an Infinite Impulse Response Butterworth Band pass...
Subarachnoid hemorrhage induces extensive neuronal cell death, leading to the release of damage-associated molecular patterns (DAMPs). These DAMPs, along with hemoglobin and corpses, trigger localized inflammation. Signal regulatory protein alpha (SIRPα) plays a crucial role in efferocytosis by acting as "don't eat-me" signal, modulating inflammation tissue homeostasis. However, precise function mechanisms SIRPα remain unclear. Proteomic analysis cerebrospinal fluid (CSF) reveals that levels...
Spinal cord injury is followed by glial scar formation, which was long seen mainly as a physical barrier preventing axonal regeneration. Glial astrocytes lead to formation and produce inhibitory factors prevent axons from growing through the scar, while inhibiting conversion of reactive into scar-forming may represent an ideal treatment for CNS injury. Exercise non-invasive effective therapeutic intervention clinical rehabilitation spinal However, its precise mechanisms still need be...
Spinal cord injury (SCI) is a serious trauma of the central nervous system. The clearance myelin debris critical step in functional recovery following spinal (SCI). Recent studies have begun to reveal roles for professional phagocytes system, microglia, and their receptors control neurodegenerative disease. Repeated trans-spinal magnetic stimulation (rTSMS) has been demonstrated as noninvasive SCI treatment that enhances tissue repair recovery. In this study, we investigated role molecular...
Pseudallescheria boydii residing in the gut of coleopteran (Holotrichia parallela) larva produces four new epipolythiodioxopiperazine (ETP) boydines A-D (3-6) and two novel sesquiterpene boydenes A (7) B (10), addition to bisdethiobis(methylthio)-deacetylaranotin (1), bisdethiodi(methylthio)-deacetylapoaranotin (2), AM6898 (8) ovalicin (9). The structure elucidation was accomplished by a combination spectral methods with quantum chemical calculations optical rotations electronic circular...
The de novo prediction of RNA tertiary structure remains a grand challenge. Predicted solvent accessibility provides an opportunity to address this To the best our knowledge, there is only one method (RNAsnap) available for prediction. However, its performance unsatisfactory protein-free RNAs.We developed RNAsol, new algorithm predict accessibility. RNAsol was built based on improved sequence profiles from covariance models and trained with long short-term memory (LSTM) neural networks....
Abstract The limited selection of immunosuppressants in the clinic hampers efficient management immune disorders such as rejections after organ transplantations. However, search for new immunosuppressive compounds remains random and creates inevitably financial laborious wastes. Herein, we present an immunity‐inspired discovery strategy that rationally allows identification from endophyte culture, exemplified by peptide trichomide A. This compound exerts its action more selectively than...
Threading is one of the most effective methods for protein structure prediction. In recent years, increasing accuracy in contact map prediction opens a new avenue to improve performance threading algorithms. Several preliminary studies suggest that with predicted contacts, algorithms can be improved greatly. There still much room explore make better use contacts.We have developed contact-assisted algorithm named CATHER using both conventional sequential profiles and by deep learning-based...
This paper describes improved optimization method that combines the one-factor-at-a-time (OFAT), Plackett-Burman design, and response surface (RSM), which were used to optimize medium for production of fumigaclavine C (FC) helvolic acid (HA) from endophytic Aspergillus fumigatus CY018 simultaneously. The ideal carbon nitrogen sources two compounds assessed initially via method. Three key cultivation factors (pH, phosphate, inoculum size) chosen based on results subsequently optimized by...
Objective * These authors contributed equally to this work. To test the hypothesis that there would be better clinical outcomes following treatment of patients with acute lung injury (ALI) using noninvasive positive-pressure mechanical ventilation (NIPPV) delivered via a complex critical care ventilator compared conventional mini-ventilator. Methods Patients ALI who required NIPPV were prospectively enrolled and randomly divided between three intervention groups: group A was ventilated...
This paper briefly introduces the concept of RSA algorithm, and presents flaws other existing implementations Algorithm in Java, thereby designs our improved implementation analyzes performance implementation. Wepsilave developed a piece software for encrypting decrypting text files.
A number of alignment-free methods have been proposed for phylogeny reconstruction over the past two decades. But there are some long-standing challenges in these methods, including requirement huge computer memory and CPU time, existence duplicate computations. In this article, we address with idea compressed vector, fingerprint scalable management. With ideas developed DLTree algorithm efficient implementation dynamical language model whole genome-based phylogenetic analysis. The was...