A5010496598- Neuroscience and Neuropharmacology Research
- Neurotransmitter Receptor Influence on Behavior
- Memory and Neural Mechanisms
- Receptor Mechanisms and Signaling
- Epigenetics and DNA Methylation
- Tryptophan and brain disorders
- Pharmacogenetics and Drug Metabolism
- Neuropeptides and Animal Physiology
- Diet and metabolism studies
- Neuroinflammation and Neurodegeneration Mechanisms
- MicroRNA in disease regulation
- Stress Responses and Cortisol
- Ion channel regulation and function
- Nicotinic Acetylcholine Receptors Study
- Cannabis and Cannabinoid Research
- Cancer-related molecular mechanisms research
- Extracellular vesicles in disease
- Pain Mechanisms and Treatments
- Pain Management and Opioid Use
- Seed and Plant Biochemistry
- Digital Mental Health Interventions
- Cardiac Ischemia and Reperfusion
- Signaling Pathways in Disease
- Engineering Education and Technology
- Cerebrovascular and Carotid Artery Diseases
Zunyi Medical University
2025
Ningbo University
2013-2024
Ningbo Kangning Hospital
2021-2024
Naval University of Engineering
2024
Chongqing University
2024
University of Nottingham Ningbo China
2013-2023
Tianshui Normal University
2023
North Carolina State University
2014-2018
Guangxi Maternal and Child Health Hospital
2015
University of North Carolina at Chapel Hill
2009-2014
Contextual stimulus control over instrumental drug-seeking behavior relies on the reconsolidation of context-response-drug associative memories into long-term memory storage following retrieval-induced destabilization. According to previous studies, basolateral amygdala (BLA) and dorsal hippocampus (DH) regulate cocaine-related reconsolidation; however, it is not known whether these brain regions interact or independently this phenomenon. To investigate question, rats were trained lever...
Single nucleotide polymorphisms (SNPs) in the OPRM1 gene have been associated with vulnerability to opioid dependence. The current study identifies an association of intronic SNP (rs9479757) severity heroin addiction among Han-Chinese male addicts. Individual analysis and haplotype-based additional SNPs locus showed that mild was AG genotype, whereas severe GG genotype. In vitro studies such as electrophoretic mobility shift assay, minigene, siRNA, antisense morpholino oligonucleotide...
The occurrence and development of colorectal cancer (CRC) is an incredibly long process that involves continuous changes in the tumor microenvironment. These constant may ultimately result genetic alterations metabolic processes some symbiotic bacteria as a way to adapt changing environment. Patients with CRC exhibit altered abundance Bacteroides fragilis (B. fragilis) indicated by several studies. To better understand genomic characteristics virulence spectrum B. strains tissues, were...
Orbitofrontal cortex (OFC) damage produces impaired decision-making, impulsivity and perseveration potentially contributes to compulsive drug seeking in cocaine users. To further explore this phenomenon, we assessed the role of lateral OFC (lOFC) context-induced cocaine-seeking behavior reinstatement model relapse. Rats were trained lever press for intravenous infusions a distinct environmental context (cocaine-paired context) followed by extinction training different (extinction-paired...
ABSTRACT The functional integrity of the nucleus accumbens (NAC) core and shell is necessary for contextual cocaine‐seeking behavior in reinstatement animal model drug relapse; however, neuropharmacological mechanisms underlying this phenomenon are poorly understood. present study evaluated contribution metabotropic glutamate receptor subtype 1 (mGluR1) α‐amino‐3‐hydroxy‐5‐methyl‐4‐isoxazolepropionic acid (AMPA)/kainate populations to context‐induced behavior. Rats were trained lever press...
Repeated cocaine exposure enhances glutamatergic output from the medial prefrontal cortex to subcortical brain regions. Loss of inhibitory control cortical pyramidal neurons may partly account for this augmented glutamate output. Recent research indicated that repeated reduced ability Group II metabotropic receptors modulate behavioral and neurochemical responses cocaine. Thus, experiments described below examined whether alters receptor regulation mesocorticolimbic transmission using in...
Despite the well-documented involvement of dopamine D1-like receptor stimulation in cocaine-induced goal-directed behaviours, little is known about specific contribution populations dorsal hippocampus (DH) to drug context-induced cocaine-seeking or drug-reinforced instrumental behaviours. To investigate this question, rats were trained lever press for un-signalled cocaine infusions a distinct context followed by extinction training different context. Cocaine-seeking behaviour (non-reinforced...
Heroin use disorder is a chronic and relapsing disease that induces persistent changes in the brain. The diagnoses of heroin disorders are mainly based on subjective reports no valid biomarkers available. Recent researches have revealed circulating miRNAs useful non-invasive for diagnosing brain diseases such as Alzheimer's disease, multiple sclerosis, schizophrenia, bipolar disorder. However, studies diagnosis rarely reported. In this study, we investigated differential expression plasma 57...