A5039742042- Plant Reproductive Biology
- Plant Physiology and Cultivation Studies
- Plant Molecular Biology Research
- Liver Disease Diagnosis and Treatment
- Plant tissue culture and regeneration
- Cancer-related molecular mechanisms research
- Alcohol Consumption and Health Effects
- Endometrial and Cervical Cancer Treatments
- Plant Stress Responses and Tolerance
- Legume Nitrogen Fixing Symbiosis
- Mycotoxins in Agriculture and Food
- Proteins in Food Systems
- Genomics, phytochemicals, and oxidative stress
- Acute Myeloid Leukemia Research
- Diet, Metabolism, and Disease
- Peroxisome Proliferator-Activated Receptors
- Advances in Cucurbitaceae Research
- Circular RNAs in diseases
- Ovarian cancer diagnosis and treatment
- MicroRNA in disease regulation
- Plant responses to water stress
- Carcinogens and Genotoxicity Assessment
- Pharmacological Effects of Natural Compounds
- Lung Cancer Research Studies
- Endometriosis Research and Treatment
Chongqing Medical University
2016-2025
Sun Yat-sen University
2023-2024
Guangxi Medical University
2020-2024
Sichuan University
2006-2024
Sun Yat-sen University Cancer Center
2023-2024
State Key Laboratory of Oncology in South China
2024
Third Affiliated Hospital of Sun Yat-sen University
2023-2024
West China Hospital of Sichuan University
2024
China Three Gorges University
2022-2023
Nanjing Agricultural University
2019-2023
Olfactory receptors (ORs) are expressed not only in the sensory neurons of olfactory epithelium, where they detect volatile substances, but also various other tissues their potential functions largely unknown. Here, we report physiological characterization human OR51E2, named prostate-specific G-protein-coupled receptor (PSGR) due to its reported up-regulation prostate cancer. We identified androstenone derivatives as ligands for recombinant receptor. PSGR can be activated with odorant...
Abstract MicroRNAs (miRNAs) are important regulators of plant growth and development. Previously, we identified a group conserved novel miRNA families from soybean (Glycine max) roots. Many these miRNAs specifically induced during soybean-Bradyrhizobium japonicum interactions. Here, examined the gene expression levels six investigated their functions in nodule We used northern-blot analyses to study tissue specificity time course expression. Transgenic miR482, miR1512, miR1515 led...
Alternative splicing (AS), as a potent and pervasive mechanism of transcriptional regulatory, expands the genome's coding capacity involves in initiation progression cancer. Systematic analysis alternative colorectal cancer (CRC) is lacking greatly needed.RNA-Seq data corresponding clinical information CRC cohort were downloaded from TCGA portal. Then, java application, known SpliceSeq, was used to evaluate RNA patterns calculate Percent Spliced In (PSI) value. Differently expressed AS...
Auxin action is mediated by a complex signalling pathway involving transcription factors of the auxin response factor (ARF) family. In Arabidopsis, microRNA160 (miR160) negatively regulates three ARF genes (ARF10/ARF16/ARF17) and therefore controls several developmental processes, including primary lateral root growth. Here, we analysed role miR160 in development nodulation Medicago truncatula Gaertn. Bioinformatic analyses identified two main mtr-miR160 variants (mtr-miR160abde mtr-miR160c)...
Fluorophores SYTO 9 and propidium iodide (PI) are extensively applied in medicine, food industry environmental monitoring to assess the viability of bacteria. However, actual performance these dyes remains largely unknown. In addition, their effects on physiology cells have not been elucidated. Here we characterized two Brevibacillus brevis under optimized staining. We found that entered continuously while PI tended adhere cell wall before entering cell. results showed a high amount altered...
Seven-transmembrane receptors typically mediate olfactory signal transduction by coupling to G-proteins. Although insect odorant have seven transmembrane domains like G-protein coupled receptors, they an inverted membrane topology, constituting a key difference between the systems of insects and other animals. While heteromeric ORs form ligand-activated non-selective cation channels in recombinant expression systems, evidence for involvement cyclic nucleotides G-proteins odor reception is...
Single nucleotide polymorphisms (SNPs) in the OPRM1 gene have been associated with vulnerability to opioid dependence. The current study identifies an association of intronic SNP (rs9479757) severity heroin addiction among Han-Chinese male addicts. Individual analysis and haplotype-based additional SNPs locus showed that mild was AG genotype, whereas severe GG genotype. In vitro studies such as electrophoretic mobility shift assay, minigene, siRNA, antisense morpholino oligonucleotide...
Under current climate change, increasing mean temperatures are not only causing hotter summers, but temperature variability is as well. Phenotypic plasticity can help plants to overcome negative effects of and allow them rapidly adjust traits adverse conditions. Moreover, genetic variation in such could provide potential for adaptive evolution response changing variability. Here, we conducted an experiment with 11 Arabidopsis thaliana genotypes investigate intraspecific plant responses two...
Hepatic stellate cells (HSCs) activation is an important step in the process of hepatic fibrosis. NOX4 and reactive oxygen species expressed HSCs play role liver Forsythiaside A (FA), a phenylethanoid glycoside extracted isolated from Forsythiae Fructus, has significant antioxidant activities. However, it not clear whether FA can inhibiting through regulating NOX4/ROS pathway. Therefore, our purpose to explore effect mechanism on alleviate LX2 were activated by TGF-β1 vitro. MTT assay Wound...
Nucleus accumbens-associated protein 1 (NACC1) regulates various types of biological processes. It is a transcription factor associated with cancer. NACC1 overexpressed in many human malignancies and can regulate the progression, metastasis, drug resistance cancer cells. However, its precise role acute myeloid leukemia (AML) remains unknown. This study aimed to unravel basic mechanism AML. Our findings demonstrated that immensely expressed AML Lentiviral vector-mediated knockdown inhibited...
This study aimed to understand the exact function and potential mechanism of miR-4500 in colorectal cancer (CRC). In this study, expression was decreased both CRC cells tissues, downregulated indicated advanced tumor stage poor survival. By bisulfite sequencing analysis, we found that CpG island promoter region hypermethylated tissues compared with normal control non-tumor respectively. Functionally, gain- loss-of-function analyses suppressor role miR-4500: it suppressed cell proliferation,...
The purpose of this study was to find a cut-off value the immunohistochemical parameter Ki67 for stage I-II endometrial cancer.The clinicopathological data 318 patients with stages cancer who received primary surgical treatment were retrospectively analyzed. A predicting recurrence determined by using receiver operating characteristic curve and Youden index. Cox regression performed screen factors associated cancer. Based on Ki67, divided into two groups, differences parameters between...