To investigate the optimal cut-off value of immunohistochemical marker Ki67 as a prognostic factor to predict recurrence non-muscle invasive bladder urothelial carcinoma (NMIBUC). A total 331 patients diagnosed with NMIBUC who underwent surgery in Yongchuan Hospital and Second Affiliated Chongqing Medical University from January 2012 2020 were finally included this study. The for predicting was calculated by ROC curve Youden index. According value, divided into high ratio group low group,...

The purpose of this study was to find a cut-off value the immunohistochemical parameter Ki67 for stage I-II endometrial cancer.The clinicopathological data 318 patients with stages cancer who received primary surgical treatment were retrospectively analyzed. A predicting recurrence determined by using receiver operating characteristic curve and Youden index. Cox regression performed screen factors associated cancer. Based on Ki67, divided into two groups, differences parameters between...

ABSTRACT African swine fever (ASF) is a highly contagious viral disease that affects domestic and wild pigs. The causative agent of ASF virus (ASFV), large double-stranded DNA with complex virion structure. Among the various proteins encoded by ASFV, A137R crucial structural protein associated its virulence. However, structure molecular mechanisms underlying functions remain largely unknown. In this study, we present determined cryogenic electron microscopy single-particle reconstruction,...

Background The purpose of this study was to establish a nomogram combining classical parameters and immunohistochemical markers predict the recurrence patients with stage I-II endometrial cancer (EC). Methods 419 who received primary surgical treatment at First Affiliated Hospital Chongqing Medical University were involved in as training cohort. Univariate multivariate Cox regression analysis screening prognostic factors performed cohort develop model, which further validated 248 (validation...

The prognostic value of the Musashi-2 (MSI2) gene has not yet been studied in childhood acute lymphoblastic leukemia (ALL). In our study, MSI2 mRNA levels 119 patients with newly-diagnosed ALL were examined and analyzed regard to clinical characteristics outcomes. demonstrated significantly higher than healthy controls. addition, correlated disease status IK6 mutation status. Survival analyses showed that predicted worse outcomes ALL. Moreover, multivariate analyses, overexpression retained...

Abstract Background and Objectives We aimed to explore the capacity of combined ratio biomarkers predict recurrence Stage I–III endometrial cancer (EC). Methods A total 473 patients were enrolled after screening. The cut‐off value was calculated by receiver operating characteristic curve (ROC). univariate multivariate Cox regression analysis used assess correlation between EC. differences clinicopathological parameters two groups divided based on threshold compared. Result ROC showed that...

Combining traditional clinical parameters with neuroendocrine markers to construct a nomogram model predict the postoperative recurrence of carcinoma cervix (NECC).A total 257 patients were included in this study. Univariate and multivariate Cox regression analyses used establish training cohorts, which was further validated validation cohorts. The calibration curve conduct internal external verification model.Overall, 41 relapse cases observed (23 cases) (18 univariate analysis...

Nipah virus (NiV) is a non-segmented, negative-strand (NNS) RNA virus, belonging to Paramyxoviridae. The polymerase complex, composed of large (L) protein and tetrameric phosphoprotein (P), responsible for genome transcription replication by catalyzing NTP polymerization, mRNA capping cap methylation. Here, we determine the cryo-electron microscopy (cryo-EM) structure fully bioactive NiV L-P complex at resolution 3.19 Å. displays conserved architecture like other NNS polymerases L interacts...

The aim of this study was to establish a nomogram predict the recurrence endometrial cancer (EC) by immunohistochemical markers and clinicopathological parameters evaluate discriminative power model.The data 473 patients with stages I-III who had received primary surgical treatment between October 2013 May 2018 were randomly split into two sets: training cohort validation at predefined ratio 7:3. Univariate multivariate Cox regression analysis screening prognostic factors performed in...

Birth defects have brought about major public health problems, and studying the clinical outcomes of most common prenatal central nervous system abnormality, namely, fetal ventriculomegaly (VM), is helpful for improving reproductive fertility quality. This a retrospective cohort study from 2011 to 2020 in West China Second University Hospital, Sichuan University, aiming evaluate short-term long-term VM over 37 weeks' gestation exclude influence preterm birth. The analyzed data 401 term...

Abstract Introduction Relapse remained the major obstacle to improving prognosis of children with acute lymphoblastic leukemia (ALL). This study aimed investigate changing patterns Ig / TCR gene rearrangements between diagnosis and relapse clinical relevance explore mechanism leukemic relapse. Methods Clonal were screened by multiplex PCR amplification in 85 paired diagnostic bone marrow (BM) samples from ALL. The new presented at quantitatively assessed RQ‐PCR approach targeting...

This study aims to determine the optimal cut-off value of Ki-67 better predict recurrence early low-risk endometrial cancer (EC).Seven hundred and forty-eight patients diagnosed with EC from West China Second Hospital Sichuan University First Affiliated Chongqing Medical were retrospectively analyzed. The receiver operating characteristic curve (ROC) Youden index used calculate expression. clinicopathological indexes between two groups divided by compared. univariate multivariate regression...

Chromosome aberration is one of the common causes male infertility. Isodicentric chromosome a chromosomal in which two arms are identical morphology and genetics connected by centromeres. We firstly reported case infertile with nonmosaic 46, X, idic (Y) (qter-p11.31::p11.31-qter) but sex-determining region Y (SRY). The broken site (p11.31). patients' clinical phenotype was azoospermia short stature. Fluorescence situ hybridisation (FISH), microarray comparative genomic (array CGH) related...

Abstract Purpose Combining traditional clinical parameters with neuroendocrine markers to construct a nomogram model predict the postoperative recurrence of carcinoma cervix (NECC). Methods 257 patients were included in this study, which, 171 diagnosed NECC who underwent surgery at West China Second Hospital Sichuan University considered as part training cohort. The univariate and multivariate Cox regression analyses used screening high-risk factors related cancer cohort establish which was...

Cotton fiber yield depends on the density of cell initials that form ovule epidermis. Fiber initiation is triggered by MYB-MIXTA-like transcription factors (GhMMLs) and requires a sucrose supply. Ethylene or its precursor ACC (1-aminocyclopropane-1-carboxylic acid) suggested to affect yield. The Gossypium hirsutum (L.) genome contains 35 ACS genes (GhACS) encoding synthases. Here, we explored role GhACS family member in regulation initiation. Expression analyses showed GhACS6.3 gene pair was...

Abstract Purpose: The recurrence is a significant impediment to the cure of pediatric acute lymphoblastic leukemia (ALL). We studied correlation between changes in immunoglobulin ( Ig )/T-cell receptor TCR ) gene rearrangement patterns and clinical characteristics relapsed ALL children. To determine where clone originated, we traced rearrangements levels dynamically from initial diagnosis relapse. Methods: used multiplex polymerase reaction (PCR) detect Ig/TCR at real-time quantitative chain...