A5100672866- Parasitic infections in humans and animals
- Phytochemistry and biological activity of medicinal plants
- Pharmacological Effects of Natural Compounds
- Plant-based Medicinal Research
- Ginseng Biological Effects and Applications
- Toxoplasma gondii Research Studies
- Advanced Neuroimaging Techniques and Applications
- Parasitic Infections and Diagnostics
- Liver Disease Diagnosis and Treatment
- Chromatography in Natural Products
- Female Genital Mutilation/Cutting Issues
- Phytochemistry and Biological Activities
- Traditional Chinese Medicine Analysis
- Ginkgo biloba and Cashew Applications
- Catalytic Alkyne Reactions
- Nanoparticle-Based Drug Delivery
- Computational Drug Discovery Methods
- Radiomics and Machine Learning in Medical Imaging
- Catalytic C–H Functionalization Methods
- Genital Health and Disease
- Berberine and alkaloids research
- Genetic Mapping and Diversity in Plants and Animals
- Plant and Fungal Interactions Research
- Plant Virus Research Studies
- Alcohol Consumption and Health Effects
Kunming University of Science and Technology
2023-2025
Northeast Agricultural University
2024-2025
First Affiliated Hospital of Dalian Medical University
2016-2025
Zunyi Medical University
2017-2025
Dalian Medical University
2016-2025
Dalian University of Technology
2025
Yunnan University
2024
Henan University
2020-2024
Nanfang Hospital
2024
Capital Medical University
2024
Abstract A synthetic protocol was developed to synthesize highly functionalized 3‐furylmethyl chromones from enynones and o ‐hydroxyphenyl enaminones via silver‐catalyzed cascade bis‐heteroannulation reaction. This strategy features broad substrate scope good functional group tolerance. Furthermore, the chromone skeleton shows potential application value through further gram‐scale synthesis derivatization.
Alzheimer's disease is a common neurodegenerative disease, and patients with early-onset (onset age < 65 years) often have atypical symptoms, which are easily misdiagnosed missed. Multimodality neuroimaging has become an important diagnostic follow-up method for AD its non-invasive quantitative advantages.We report case of 59-year-old female diagnosis depression at the 50 after 46-year-old onset 9-year observation, who developed cognitive dysfunction manifested by memory loss disorientation...
Intelligently responsive nanoparticles can improve insecticidal activity against target organisms and reduce the use of pesticides in agriculture. In this study, enzymatic hydrolysis lignin (EHL) nanocarriers with enzyme responsiveness were successfully prepared by electrostatic interaction, abamectin (Abm)-loaded EHL-based (Abm@L-CL) investigated. The release behavior Abm@L-CL showed that Abm was released rapidly presence cellulase pectinase but slowly under natural conditions. treatment...
Hepatic stellate cells (HSCs) activation is an important step in the process of hepatic fibrosis. NOX4 and reactive oxygen species expressed HSCs play role liver Forsythiaside A (FA), a phenylethanoid glycoside extracted isolated from Forsythiae Fructus, has significant antioxidant activities. However, it not clear whether FA can inhibiting through regulating NOX4/ROS pathway. Therefore, our purpose to explore effect mechanism on alleviate LX2 were activated by TGF-β1 vitro. MTT assay Wound...
Pathological and neuroimaging alterations in the cerebellum of Alzheimer's disease (AD) patients have been documented. However, role cerebellum-derived radiomic structural connectome modeling prediction AD progression remains unclear. Radiomic features were extracted from magnetic resonance imaging (MRI) Disease Neuroimaging Initiative (ADNI) dataset (n = 1319) an in-house 308). Integrated machine learning models developed to predict conversion risk normal cognition (NC) mild cognitive...
An efficient AgNO3‐catalyzed regio‐selective bis‐heteroannulation of o‐hydroxyphenyl enaminones with yne‐enones for the synthesis highly functionalized 3‐(furan‐3‐ylmethyl) chromones has been developed. The protocol enables simultaneous construction chromone and furan skeleton in one‐step cascade reaction. Furthermore, high easily accessible starting materials, regioselectivity, room temperature, good to excellent yields, broad substituent tolerance, further gram‐scale derivatization make...
Bis(2-ethylhexyl) phthalate (DEHP) is an endocrine disruptor that may cause damage to several species. Quercetin (Que), a common flavonoid, has anti-inflammation, antioxidation, and immune regulation properties. In this study, we identified DEHP-exposed or Que-antagonist groups in chicken MSB-1 cells explore whether Que can mitigate DEHP-caused bursa of Fabricius pyroptosis necroptosis. The findings demonstrated reduced the expression necroptosis pyroptosis, inhibited mitogen-activated...
Highly functionalized benzodiazepine skeletons were efficiently synthesized via a Rh( iii )-catalyzed selective mono- and dual-C–H bond functionalization/cyclization reaction between readily available 1-aryl-5-aminopyrazoles iodonium ylides under.
Taenia solium ( T. ) cysticercosis is a neglected parasitic zoonosis that occurs in developing countries. Since has complex life cycle includes eggs, oncospheres, cysticerci, and adults, presumably many proteins are produced enable them to survive establish an infection within the host. The objectives of this study were perform comparative proteomic analysis two ontogenetic stages (cysticerci adult) analyze their differential expression proteins. Methods separated by High Performance Liquid...
BackgroundIn the context of sepsis patients, hypertension has a significant impact on likelihood developing sepsis-associated acute kidney injury (S-AKI), leading to considerable burden. Moreover, is responsible for over 50 % cases injuries (AKI) and linked an increased death during hospitalization. The objective this research develop dependable strong nomogram framework, utilizing variables accessible within first 24 h admission, anticipation S-AKI in patients who have...
Liver injury induced by Polygonum multiflorum Thunb. (PM) have been reported since 2006, which aroused widespread concern. However, the toxicity mechanism of PM liver remained unclear. In this study, different doses after long-term administration was investigated in rats metabolomics and traditional approaches. Rats were randomly divided into control group groups. groups oral administered low (10 g/kg), medium (20 high (40 g/kg) dose, while distilled water. After 28 days continuous...
The link between glymphatic system function in the brain and alterations white-matter microstructure among individuals with major depressive disorder (MDD) remains unclear. This study aimed to examine assessment of patients MDD using diffusion tensor imaging along perivascular space (DTI-ALPS) index evaluate its association cerebral-white-matter abnormalities neuropsychological scores.