A5083943092- Immune Cell Function and Interaction
- T-cell and B-cell Immunology
- MicroRNA in disease regulation
- Single-cell and spatial transcriptomics
- Cancer-related molecular mechanisms research
- Cytomegalovirus and herpesvirus research
- Diabetes and associated disorders
- DNA Repair Mechanisms
- Immune cells in cancer
- RNA Research and Splicing
- Circular RNAs in diseases
- Acute Myeloid Leukemia Research
- Gastrointestinal motility and disorders
- RNA modifications and cancer
- Spinal Dysraphism and Malformations
- Mast cells and histamine
- Genomic variations and chromosomal abnormalities
- Genetics and Neurodevelopmental Disorders
- FOXO transcription factor regulation
- RNA regulation and disease
- Inflammasome and immune disorders
- interferon and immune responses
- RNA and protein synthesis mechanisms
- Cerebrospinal fluid and hydrocephalus
- Autophagy in Disease and Therapy
Scripps Research Institute
2018-2025
Hebei Medical University
2024
Dalian Medical University
2024
First Affiliated Hospital of Dalian Medical University
2024
The University of Texas MD Anderson Cancer Center
2024
First Affiliated Hospital of Hebei Medical University
2024
Wuhan University of Science and Technology
2024
Mayo Clinic
2021-2023
WinnMed
2021-2023
Mayo Clinic in Arizona
2021
Induction of protective vaccine responses, governed by the successful generation antigen-specific antibodies and long-lived memory T cells, is increasingly impaired with age. Regulation cell proteome a dynamic network microRNAs crucial to responses. Here, we show that activation-induced upregulation miR-21 biases transcriptome differentiating cells away from toward inflammatory effector cells. Such bias also characteristic responses in older individuals who have increased expression reversed...
Neurotransmitters have been shown to regulate immune responses, and thereby are critically related autoimmune diseases. Here we showed that depletion of dopaminergic neurons significantly promoted activation hepatic iNKT cells augmented concanavalin A (Con A)-induced liver injury. The suppressive effect dopamine on was mediated by D1-like receptor-PKA pathway. Clearance gut microbiota antibiotic cocktail reduced synthesis in intestines exacerbated damage, could be restored recovery or...
Cancer evolves to evade or compromise the surveillance of immune system, and nanoimmunotherapeutics were developed reactivate system in order inhibit cancer development.
Impaired FOXO1 expression in CD4 T cell responses from old adults causes expanded multivesicular bodies sequestering GSK3β.
Sustained activation of mTORC1 at late endosomes in primary CD4 + T cell responses older individuals impairs helper function.
The link between glymphatic system function in the brain and alterations white-matter microstructure among individuals with major depressive disorder (MDD) remains unclear. This study aimed to examine assessment of patients MDD using diffusion tensor imaging along perivascular space (DTI-ALPS) index evaluate its association cerebral-white-matter abnormalities neuropsychological scores.
The MRE11/RAD50/NBS1 (MRN) complex plays multiple roles in the maintenance of genome stability. MRN is associated with replication forks to preserve fork integrity and also required for end resection at double-strand breaks (DSBs) facilitate homologous recombination (HR). critical need proper control MRE11 nuclease activity highlighted by extensive nascent strand DNA degradation driven BRCA-deficient cells, leading instability increased sensitivity chemotherapeutics. In this study, we...
Genome instability often arises at common fragile sites (CFSs) leading to cancer-associated chromosomal rearrangements. However, the underlying mechanisms of how CFS protection is achieved not well understood. We demonstrate that BLM plays an important role in maintenance genome stability structure-forming AT-rich sequences derived from CFSs (CFS-AT). deficiency leads increased DSB formation and hyper mitotic recombination CFS-AT induces plasmids containing CFS-AT. further showed required...
Invariant natural killer T (iNKT) cells are innate-like lymphocytes that express an invariant cell receptor (TCR), which recognizes glycolipid antigens presented on CD1d molecules. These phenotypically and functionally distinct from conventional cells. When we characterized the metabolic activity of iNKT cells, consistent with their activated phenotype, found they had much less mitochondrial respiratory capacity but increased glycolytic in comparison to naïve CD4+ After TCR engagement,...
Abstract MicroRNAs play an important role in the regulation of T cell development, activation, and differentiation. One most abundant microRNAs lymphocytes is miR-181a, which controls receptor (TCR) activation thresholds thymic selection as well peripheral responses. We previously found that miR-181a levels decline cells elderly. In this study, we identified TCF1 a transcriptional regulator pri-miR-181a. A old individuals accounted for reduced expression impairing TCR signaling. Inhibition...
Gastric cancer (GC) has become the first malignant tumor with highest incidence rate and mortality of in China, finding therapeutic targets for gastric is great significant improving survival patients GC. Recently, many studies have shown that LncRNAs involved multiple biological progresses development This study, we screened abnormally high expression LncSHANK3 GC through TCGA database, found sponge adsorbs miR-4530, further competing MNX1 binding to miR-4530. We demonstrated interaction...
Angiogenesis has long been considered as an important strategy for ischemic injury. It reported that cellular repressor of E1A-stimulated genes (CREG1) promotes human umbilical vein endothelial cell (HUVEC) proliferation, migration, and protects (EC) from apoptosis. However, its potential effect on angiogenesis remains undefined. In the present study, we investigated role mechanisms CREG1 in promoting angiogenesis. We found adenovirus-transduced expression HUVECs increases EC tube formation...
Myelodysplastic syndromes (MDS) are heterogeneous and clonal hematological disorders. The role mechanism of necroptosis in MDS remain poorly understood.
Summary T cell aging is a complex process combining the emergence of cellular defects with activation adaptive mechanisms. Generation memory impaired, while low-inflammatory state induced, in part due to effector cells. To determine whether age-associated changes fate decisions occur early after activation, we profiled longitudinal transcriptional and epigenetic landscape induced by TCR stimulation comparing naïve CD4 + cells from young older adults. In spite attenuated signaling,...
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