A5070264015- Orbital Angular Momentum in Optics
- Microfluidic and Bio-sensing Technologies
- Sperm and Testicular Function
- Climate Change, Adaptation, Migration
- DNA Repair Mechanisms
- Sustainability and Climate Change Governance
- Microtubule and mitosis dynamics
- Micro and Nano Robotics
- Reproductive Biology and Fertility
- Spaceflight effects on biology
- Cellular Mechanics and Interactions
- Photoreceptor and optogenetics research
- Disaster Management and Resilience
- Mitochondrial Function and Pathology
- Flood Risk Assessment and Management
- Climate Change and Health Impacts
- Global Education and Multiculturalism
- Erythrocyte Function and Pathophysiology
- CRISPR and Genetic Engineering
- demographic modeling and climate adaptation
- Climate change impacts on agriculture
- Land Use and Ecosystem Services
- Environmental Justice and Health Disparities
- Genetics, Aging, and Longevity in Model Organisms
- Genetic Neurodegenerative Diseases
Cornell University
2018-2025
University of California, San Diego
2013-2024
La Jolla Bioengineering Institute
2007-2022
Beckman Laser Institute and Medical Clinic
2006-2022
University of California, Irvine
2006-2022
University of Birmingham
2018
Massachusetts Institute of Technology
2015-2016
California Institute for Regenerative Medicine
2015
A growing number of cities are preparing for climate change impacts by developing adaptation plans. However, little is known about how these plans and their implementation affect the vulnerability urban poor. We critically assess initiatives in eight worldwide find that land use planning can exacerbate socio-spatial inequalities across diverse developmental environmental conditions. argue injustices fall into two categories: acts commission, when interventions negatively or displace poor...
Microhomology-mediated end joining (MMEJ) is a major pathway for Ku-independent alternative nonhomologous joining, which contributes to chromosomal translocations and telomere fusions, but the underlying mechanism of MMEJ in mammalian cells not well understood. In this study, we demonstrated that, distinct from Ku-dependent classical MMEJ—even with very limited resection—requires cyclin-dependent kinase activities increases significantly when enter S phase. We also showed that shares initial...
CtIP plays an important role in homologous recombination (HR)-mediated DNA double-stranded break (DSB) repair and interacts with Nbs1 BRCA1, which are linked to Nijmegen breakage syndrome (NBS) familial breast cancer, respectively. We identified new CDK phosphorylation sites on found that of these newly induces association the N-terminus FHA BRCT domains Nbs1. further showed CDK-dependent events a prerequisite for ATM phosphorylate upon damage, is end resection activate HR by promoting...
Proper recognition and repair of DNA damage is critical for the cell to protect its genomic integrity. Laser microirradiation ranging in wavelength from ultraviolet A (UVA) near-infrared (NIR) can be used induce a defined region nucleus, representing an innovative technology effectively analyze vivo double-strand break (DSB) process mammalian cells. However, damage-inducing characteristics different laser systems have not been fully investigated. Here we compare nanosecond nitrogen 337 nm...
Problem, research strategy, and findings: Cities are increasingly experiencing the effects of climate change taking steps to adapt current future natural hazard risks. Research on these efforts has identified numerous barriers adaptation planning, but not yet systematically evaluated relative importance different constraints for a large number diverse cities. We draw responses from 156 U.S. cities that participated in 2011 global survey local 60% which planning change. use logistic...
Soil-transmitted helminths are parasitic nematodes that inhabit the human intestine. These parasites, which include two hookworm species, Ancylostoma duodenale and Necator americanus, whipworm Trichuris trichiura, large roundworm Ascaris lumbricoides, infect upwards of billion people a major cause disease burden in children pregnant women. The challenge with treating these diseases is poverty, safety, inefficient public health policy have marginalized drug development distribution to control...
Recent disasters and growing concerns about climate change have spurred calls for cities to retreat from avoid developing in coastal areas. Instead, doubled down on waterfront development. We ask why with what implications, using the U.S. state of Massachusetts as a case study. By overlaying data sea level rise, land use, property taxes, we find few may lose significant levels municipal revenues long-term while others face negligible impacts. Coastal municipalities are cognizant their risks...
Abstract Comprehensive assessments of scientific knowledge are essential to inform efforts mitigate greenhouse gas emissions and adapt climate change impacts. The Fifth National Climate Assessment (NCA5), released in late 2023, adopted clear diversity, equity, accessibility, inclusion (DEAI) goals trainings, which helped diversify expert participation, broaden the types included, widen public engagement. This Letter, written by NCA5 authors, reflects on impacts limitations these suggests...
The combination of laser tweezers, fluorescent imaging, and real-time automated tracking trapping (RATTS) can measure sperm swimming speed force simultaneously with mitochondrial membrane potential (MMP). This approach is used to study the roles two sources ATP in motility: oxidative phosphorylation, which occurs mitochondria located midpiece glycolysis, along length tail (flagellum). relationships between (a) MMP (b) are studied dog human sperm. effects glucose, phosphorylation inhibitors...
To ensure timely cytokinesis, the equatorial actomyosin contractile ring constricts at a relatively constant rate despite its progressively decreasing size. Thus, per-unit-length constriction increases as perimeter decreases. understand this acceleration, we monitored cortical surface and component dynamics during first cytokinesis of Caenorhabditis elegans embryo. We found that, per unit length, amount components (myosin, anillin) increase with parallel exponential kinetics. Quantitative...
Planners and activists are identifying ways to promote equitable adaptation that counter climate injustice. This article explores how this progressive turn in compares with past movements. I argue urban politics have cyclical tendencies toward liberalism radicalism, the evolution of planning for mirrors these waves. review 10 recent guidance documents recommend strategies enhancing racially just adaptation. then assess recommendations advance three pillars reforms: redistribution, expansion...
Optical trapping is a non-invasive biophysical tool which has been widely applied to study physiological and biomechanical properties of cells. Using laser ‘tweezers’ in combination with custom-designed computer tracking algorithms, the swimming speeds relative forces individual sperm can be measured real time. This physical engineering tools used examine evolutionary effect competition primates. The results demonstrate correlation between mating type motility: from polygamous...
CtIP (CtBP-interacting protein) associates with BRCA1 and the Mre11-Rad50-Nbs1 (MRN) complex plays an essential role in homologous recombination (HR)-mediated DNA double-stranded break (DSB) repair. It has been described that forms dimers mammalian cells, but biological significance is not clear. In this study, we identified a conserved motif N terminus of CtIP, which required for dimer formation. We further showed mutants impaired forming are strongly defective HR, end resection, activation...
Residents of manufactured housing communities (MHCs) are disproportionately vulnerable to both hazards and displacement. The cooperative ownership model resident-owned (ROCs) pioneered by ROC USA helps MHC residents resist displacement, but little research assesses how tenure impacts hazard vulnerability. To fill this gap, we conduct a spatial analysis 234 sites; analyze the co-op conversion process; interview staff, technical assistance providers, resident leaders. Although communities,...
Climate change-exacerbated flooding has renewed interest in property buyouts as a pillar of managed retreat from coastal zones and floodplains the United States. However, federal buyout programs are widely critiqued for being inaccessible inequitable. To learn whether how subnational overcome these limitations, we examined five leading US state, county, local to see what they teach us about redesigning future policies. Our mixed-methods research used interviews document analysis develop case...
This study examines the use of optical trapping as a quantitative measure sperm motility. The effects laser trap duration and power on motility are described between swimming force, swimmimg speed, speed progression (SOP) score. Sperm (SOP scores 2–4) were trapped by continuous-wave 1064 nm single-point gradient trap. Trap quantified for 15, 10, 5 seconds at 420 mW power. Laser powers mW, 350 300 250 five seconds. Swimming SOP score relationships examined shown to minimally affect forces...