A5040073201- Phagocytosis and Immune Regulation
- Parasites and Host Interactions
- Immunotherapy and Immune Responses
- Dermatology and Skin Diseases
- Immune Cell Function and Interaction
- Erythrocyte Function and Pathophysiology
- Insect and Pesticide Research
- SARS-CoV-2 and COVID-19 Research
- Parasite Biology and Host Interactions
- COVID-19 Clinical Research Studies
- Helminth infection and control
- Extracellular vesicles in disease
- Complement system in diseases
- Vector-borne infectious diseases
- T-cell and B-cell Immunology
- Phytase and its Applications
- Insect Resistance and Genetics
- Adolescent Sexual and Reproductive Health
- Isotope Analysis in Ecology
- SARS-CoV-2 detection and testing
- Syphilis Diagnosis and Treatment
- Autoimmune Bullous Skin Diseases
- Systemic Lupus Erythematosus Research
- Chronic Lymphocytic Leukemia Research
- Reproductive tract infections research
Stanford University
2017-2023
California Institute for Regenerative Medicine
2017-2022
Institute for Stem Cell Biology and Regenerative Medicine
2022
SRI International
2014
University of California, San Diego
2012-2013
Harbin University of Commerce
2010
Abstract CD47 is a cell surface molecule that inhibits phagocytosis of cells express it by binding to its receptor, SIRPα, on macrophages and other immune cells. expressed at different levels neoplastic normal Here, reveal mechanisms which generate this dominant ‘don’t eat me’ signal, we analyse the regulatory genomic landscape. We identify two distinct super-enhancers (SEs) associated with in certain cancer types. show set active constituent enhancers, located within SEs, regulate...
Soil-transmitted helminths are parasitic nematodes that inhabit the human intestine. These parasites, which include two hookworm species, Ancylostoma duodenale and Necator americanus, whipworm Trichuris trichiura, large roundworm Ascaris lumbricoides, infect upwards of billion people a major cause disease burden in children pregnant women. The challenge with treating these diseases is poverty, safety, inefficient public health policy have marginalized drug development distribution to control...
Psoriasis is a chronic autoimmune disease affecting the skin and characterized by aberrant keratinocyte proliferation function. Immune cells infiltrate release proinflammatory cytokines that play important roles in psoriasis. The Th17 network, including IL-23 IL-22, has recently emerged as critical component pathogenesis of IL-22 signaling dependent on JAK family protein tyrosine kinases, making inhibition an appealing strategy for treatment In this study, we report activity SAR-20347, small...
Ascaris suum and lumbricoides are two closely related geo-helminth parasites that ubiquitously infect pigs humans, respectively. infection in is considered a good model for A. humans because of similar biology tissue migration to the intestines. infections children associated with malnutrition, growth cognitive stunting, immune defects, and, extreme cases, life-threatening blockage digestive tract aberrant into bile duct peritoneum. Similar effects can be seen poor feed efficiency...
Abstract Prolonged exposure of CD8 + T cells to antigenic stimulation, as in chronic viral infections, leads a state diminished function termed exhaustion. We now demonstrate that even during exhaustion there is subset functional defined by surface expression SIRPα, protein not previously reported on lymphocytes. On SIRPα cells, co-inhibitory receptors counterbalanced co-stimulatory and it only actively proliferate, transcribe IFNγ show cytolytic activity. Furthermore, target express the...
It is well understood that the adaptive immune response to infectious agents includes a modulating suppressive component as an activating component. We now show very early innate also has immunosuppressive Infected cells upregulate CD47 "don't eat me" signal, which slows phagocytic uptake of dying and viable downstream antigen-presenting cell (APC) functions. A mimic acts essential virulence factor encoded by all poxviruses, but expression on infected was found be upregulated even pathogens,...
Background Hookworm infections are one of the most important parasitic humans worldwide, considered by some second only to malaria in associated disease burden. Single-dose mass drug administration for soil-transmitted helminths, including hookworms, relies primarily on albendazole, which has variable efficacy. New and better hookworm therapies urgently needed. Bacillus thuringiensis crystal protein Cry5B potential as a novel anthelmintic been extensively studied roundworm Caenorhabditis...
ABSTRACT Vaccination induced antibody and T-cell immune responses are important for systemic protection from COVID-19. Because SARS-CoV-2 infects is transmitted by oral-pharyngeal mucosa, we wished to test mucosal antibodies elicited natural infection or intramuscular vaccine injection. In a non-randomized observational study, measured against the RBD in plasma saliva convalescent vaccinated individuals tested their neutralizing potential using replication competent rVSV-eGFP-SARS-CoV-2. We...
Vaginal microbicides hold great promise for the prevention of viral diseases like HIV, but failure several microbicide candidates in clinical trials has raised important questions regarding parameters to be evaluated determine vivo efficacy humans. Clinical candidate nonoxynol-9 (N9) and cellulose sulfate revealed an increase HIV infection, vaginal inflammation, recruitment susceptible lymphocytes, highlighting need identify biomarkers that can accurately predict toxicity early preclinical...
Significance Novel therapies are urgently needed that can ameliorate the clinical syndromes of cerebral malaria, most severe consequences Plasmodium infection, and thereby reduce malaria fatality. Monoclonal antibodies target CD47, a “don’t eat me” signal, have been demonstrated to enhance cellular clearance cancer cells by promoting macrophage phagocytosis. We sought adopt this therapeutic strategy associated with goals reducing disease-associated morbidity mortality. demonstrate CD47...
CD47 is an important innate immune checkpoint through its interaction with inhibitory receptor on macrophages, signal-regulatory protein α (SIRPα). Therapeutic blockade of CD47-SIRPα interactions a promising immuno-oncology treatment that promotes clearance cancer cells. However, also maintain homeostatic lymphocyte levels. In this study, we report the mouse splenic marginal zone B cell population dependent intact and leads to loss these This depletion accompanied by elevated levels...
Abstract Systemic Lupus Erythematosus (SLE) is an autoimmune disease with high levels of autoreactive B cells and circulating anti-nuclear autoantibodies. Circulating antibody-antigen immune complexes deposit in tissues, including the kidney, causing chronic inflammation irreparable tissue damage. The hematopoietic system expresses a unique isoform phosphatidylinositol 3 kinase (PI3K) catalytic subunit, termed delta (PI3Kδ). It critical for cell survival function, its inhibition results...
Over the last decade, more data has revealed that increased surface expression of "don't eat me" CD47 protein on cancer cells plays a role in immune evasion and tumor progression, with blockade emerging as new therapy immuno-oncology. is critical regulating cell homeostasis clearance, binding to inhibitory receptor SIRPα can prevent phagocytosis macrophage-mediated clearance. The purpose this study was examine CD47-SIRPα signal platelet Therapeutic reagents targeting axis are very promising...
A semi-works production method which the extraction and isolation of 7S 11S was improved. The isoelectric point cooling precipitation developed for fractions from low-temperature defatted soybean draff, based on indices yield determined by Kjeldahl purity SDS-PAGE. Compared optimum parameters five kinds methods that phosphate buffer’s effect is better than others, its 89.55%. optimal are as follows: pH 4.7, sedimentation time 1h, stirring rate acid 40r/min, 73.25% 50.6% respectively. 6.2,...
ABSTRACT Borrelia burgdorferi ( B. ) is a bacterial spirochete that can cause Lyme disease after infecting susceptible host. Immune responses to the bacteria are highly variable and host specific. The murine substrain, C3H/HeJ, frequently utilized mouse model of disease. In this study, we sought investigate correlation age with onset severity dermatitis, both in mice infected as well humans who have had diagnosis Female C3H/HeJ aged 6-8 weeks, 1 year, or 2 years were intraperitoneally 10 5 ....
Abstract Background Borrelia burgdorferi is a bacterial spirochete that can cause Lyme disease after infecting susceptible host. Immune responses to the bacteria are highly variable and host specific. The murine substrain, C3H/HeJ, one of most frequently utilized mouse models for disease. In this study, we sought investigate correlation age with onset severity dermatitis, both in C3H/HeJ mice infected B. as well humans who have had diagnosis Methods Female aged 6-8 weeks, 1 year, or 2 years...