A5031464629- Vector-borne infectious diseases
- LGBTQ Health, Identity, and Policy
- Phagocytosis and Immune Regulation
- Erythrocyte Function and Pathophysiology
- Female Genital Mutilation/Cutting Issues
- Climate Change and Health Impacts
- Complement system in diseases
- Intestinal and Peritoneal Adhesions
- Dermatology and Skin Diseases
- Sexual function and dysfunction studies
- Sexual Differentiation and Disorders
- Insect and Pesticide Research
- Thyroid and Parathyroid Surgery
- Spaceflight effects on biology
- Mast cells and histamine
- Urological Disorders and Treatments
- Viral Infections and Vectors
- Vibrio bacteria research studies
- Reproductive Health and Technologies
- Air Quality and Health Impacts
- Allergic Rhinitis and Sensitization
- Vitamin C and Antioxidants Research
- Hernia repair and management
- Omental and Epiploic Conditions
Stanford University
2018-2024
Institute for Stem Cell Biology and Regenerative Medicine
2019-2022
Peritoneal adhesions are fibrous tissues that tether organs to one another or the peritoneal wall and a major cause of postsurgical infectious morbidity. The primary molecular chain events leading initiation has been elusive, chiefly due lack an identifiable cell origin. Using clonal analysis lineage tracing, we have identified injured surface mesothelium expressing podoplanin (PDPN) mesothelin (MSLN) as instigator after surgery in mice. We demonstrate anti-MSLN antibody diminished adhesion...
Key Points Upon injury, the mesothelium recruits neutrophils to peritoneal space, which contributes adhesion formation. Neutrophil recruitment and macrophage-depletion kinetics in adhesions differ from normal innate response.
Lyme disease (LD) is an illness caused by the spirochete Borrelia burgdorferi (B. burgdorferi). known to disseminate through organs, including skin, joints, spinal cord, bladder, and heart, leading arthritis, neuroborreliosis, carditis. While previous studies have investigated impact of LD on pregnancy in both mice humans found presence B. uterus mice, we studied non-pregnant female reproductive tract. We use a mouse model for find ongoing severe infection tract which persists up 15-months...
Significance Novel therapies are urgently needed that can ameliorate the clinical syndromes of cerebral malaria, most severe consequences Plasmodium infection, and thereby reduce malaria fatality. Monoclonal antibodies target CD47, a “don’t eat me” signal, have been demonstrated to enhance cellular clearance cancer cells by promoting macrophage phagocytosis. We sought adopt this therapeutic strategy associated with goals reducing disease-associated morbidity mortality. demonstrate CD47...
Background: The role of allogeneic placental tissue (APT) in genital gender-affirming surgery (GAS) is not well understood. Penile inversion vaginoplasty (PIV), the most common GAS, often results healing- or wound-related complications, including scarring and neovaginal stenosis. Surgical reoperation revision are common. Methods: authors performed a retrospective analysis consecutive adult patients undergoing primary PIV during 6-year period (September 1, 2014 to September 2020). Subjects...
Innate immunity, the first line of defense against pathogens, relies on efficient elimination invading agents by phagocytes. In co-evolution host and pathogen, pathogens developed mechanisms to dampen evade phagocytic clearance. Here, we report that bacterial can clearance macrophages through mimicry at mammalian anti-phagocytic "don't eat me" signaling axis between CD47 (ligand) SIRPα (receptor). We identified a protein, P66, surface
BACKGROUND: The role of allogeneic placental tissue in genital-affirming surgery is poorly understood. most successful procedure, penile inversion vaginoplasty (PIV), oftentimes results healing or wound-related complications. Postoperative outcomes may include scarring and neovaginal stenosis. Surgical reoperation revision are common. METHODS: authors performed a retrospective analysis consecutive adult patients undergoing primary PIV during 6-year period (September 1, 2014, to September...
Over the last decade, more data has revealed that increased surface expression of "don't eat me" CD47 protein on cancer cells plays a role in immune evasion and tumor progression, with blockade emerging as new therapy immuno-oncology. is critical regulating cell homeostasis clearance, binding to inhibitory receptor SIRPα can prevent phagocytosis macrophage-mediated clearance. The purpose this study was examine CD47-SIRPα signal platelet Therapeutic reagents targeting axis are very promising...
ABSTRACT Borrelia burgdorferi ( B. ) is a bacterial spirochete that can cause Lyme disease after infecting susceptible host. Immune responses to the bacteria are highly variable and host specific. The murine substrain, C3H/HeJ, frequently utilized mouse model of disease. In this study, we sought investigate correlation age with onset severity dermatitis, both in mice infected as well humans who have had diagnosis Female C3H/HeJ aged 6-8 weeks, 1 year, or 2 years were intraperitoneally 10 5 ....
Abstract Lyme disease, caused by the bacteria Borrelia burgdorferi, is most common and rapidly growing vector-borne infectious disease in United States Europe. High variability burden among patients suggests that individual immune responses may be key drivers of clinical presentation patient outcomes. Use high resolution flow-based immunosorbent profiling revealed a subset with persistent symptoms were producing concentrations IgE specific to B. burgdorferi. Comparing C57B/6 mice, which are...
Abstract Borrelia burgdorferi is a bacterial spirochete that can cause Lyme disease (LD) after infecting susceptible host. Immune responses to the bacteria are highly variable and host specific. The murine substrain, C3H/HeJ, frequently utilized model for LD. Interestingly, over prolonged infection, mice develop dermatitis on tail skin, which shares critical features with human skin. Female C3H/HeJ aged 5–8 weeks, 1 year, or 2 years were infected intraperitoneally 105 B. burgdorferi....