A5016959825- Hormonal Regulation and Hypertension
- Alzheimer's disease research and treatments
- Lipoproteins and Cardiovascular Health
- Dementia and Cognitive Impairment Research
- Vector-borne infectious diseases
- Viral Infections and Vectors
- Cognitive Functions and Memory
- Health, Environment, Cognitive Aging
- Bioinformatics and Genomic Networks
- Folate and B Vitamins Research
- Climate Change and Health Impacts
- Blood Pressure and Hypertension Studies
University of California, San Diego
2024
University of California, Los Angeles
2021-2023
Lyme disease (LD) is an illness caused by the spirochete Borrelia burgdorferi (B. burgdorferi). known to disseminate through organs, including skin, joints, spinal cord, bladder, and heart, leading arthritis, neuroborreliosis, carditis. While previous studies have investigated impact of LD on pregnancy in both mice humans found presence B. uterus mice, we studied non-pregnant female reproductive tract. We use a mouse model for find ongoing severe infection tract which persists up 15-months...
Abstract Background Unsupervised high‐frequency cognitive‐ecological momentary assessment (EMA) on smartphones is increasingly used to assess preclinical risk for Alzheimer’s disease and related dementias (ADRD). While these tests are reliable valid individuals with ADRD, it unclear whether administering cognitive EMAs people living ADRD feasible valid. Our study explored the feasibility validity EMA in moderate severe ADRD. Method A total of 31 received web links through their care...
Abstract Background Studies of the relationship between use statins (HMG‐CoA reductase inhibitors) and subsequent cognitive performance have been variously reported to demonstrate beneficial, harmful, or no significant effects. We aimed help clarify statin long‐term trajectory in subjects cognitively normal at baseline, comparing users with known moderate (atorvastatin) high (simvastatin) lipophilicity blood‐brain barrier penetrance (LS), non‐users (nonS), other (OS). Method From a...
Abstract Background We recently reported that lipophilic statins, known to penetrate the blood‐brain barrier, were associated with accelerated decline in regional cerebral metabolism subjects early Mild Cognitive Impairment (eMCI) who had relatively low serum cholesterol levels (J Nucl Med. 2021;62:Suppl 1). In this study, we expand upon our past results by studying relationship between metabolic statin users and their neuropsychological test scores. Methods Subjects eMCI drawn from a...
Abstract Background We recently reported that lipophilic statins, known to penetrate the blood‐brain barrier, were associated with accelerated decline in cortical regions early Alzheimer’s Disease, subjects Mild Cognitive Impairment (eMCI) having normal cholesterol levels. now report predictive value of pattern regional metabolism forecasting severity over subsequent two years. Method Subjects drawn from a consecutive series enrolled Disease Neuroimaging Initiative, identifying 70 eMCI serum...