A5033596565- Head and Neck Cancer Studies
- Advances in Oncology and Radiotherapy
- Advanced Radiotherapy Techniques
- Radiology practices and education
- Lymphoma Diagnosis and Treatment
- Innovations in Medical Education
- Radiation Dose and Imaging
- Lung Cancer Research Studies
- Mentoring and Academic Development
- Lung Cancer Diagnosis and Treatment
- Cancer Diagnosis and Treatment
- Oral health in cancer treatment
- Head and Neck Surgical Oncology
- CNS Lymphoma Diagnosis and Treatment
- Salivary Gland Tumors Diagnosis and Treatment
- Neuroendocrine Tumor Research Advances
- Brain Metastases and Treatment
- Lung Cancer Treatments and Mutations
- RNA Research and Splicing
- DNA Repair Mechanisms
- Ear and Head Tumors
- Palliative Care and End-of-Life Issues
- Meningioma and schwannoma management
- Hernia repair and management
- Radiomics and Machine Learning in Medical Imaging
Wake Forest University
2020-2025
Moffitt Cancer Center
2025
University of Michigan–Ann Arbor
2019-2024
Atrium Health Wake Forest Baptist
2021-2023
Beaumont Health
2021
Howard Hughes Medical Institute
2016
Scripps Research Institute
2012-2013
Yale University
2010
Microhomology-mediated end joining (MMEJ) is a major pathway for Ku-independent alternative nonhomologous joining, which contributes to chromosomal translocations and telomere fusions, but the underlying mechanism of MMEJ in mammalian cells not well understood. In this study, we demonstrated that, distinct from Ku-dependent classical MMEJ—even with very limited resection—requires cyclin-dependent kinase activities increases significantly when enter S phase. We also showed that shares initial...
Bovine leukemia virus (BLV) infection is widespread in cattle globally and present marketed beef dairy products. Human with BLV has been reported breast lung cancer tissues was significantly associated 3 case-control studies. The purpose of this current research to determine if human blood cells antibodies are related cell infection. Standard liquid PCR Sanger DNA sequencing were used test for buffy coat (leukocytes platelets) specimens from 95 self-selected female subjects. Enzyme-linked...
Rupture and dissection are major causes of morbidity mortality in arterial aneurysm occur more frequently rapidly expanding aneurysms. Current imaging modalities provide little information on beyond size. Matrix metalloproteinase (MMP) activation plays a key role the pathogenesis aneurysm. We investigated whether MMP helps predict its propensity to expansion. <b>Methods:</b> used model carotid apolipoprotein E–deficient (apoE<sup>−/−</sup>) mice. Radiotracers with specificity for activated...
Abstract Purpose: Head and neck (HN) radiotherapy (RT) is complex, involving multiple target organ at risk (OAR) structures delineated by the radiation oncologist. Site-agnostic peer review after RT plan completion often inadequate for thorough of these structures. In-depth contours critical to maintain high-quality optimal patient outcomes. Materials Methods: In August 2020, HN Quality Assurance Conference, a weekly teleconference that included least one oncology specialist, was activated...
Brain metastases (BMs) are a common source of morbidity and mortality. Guidelines do not advise brain surveillance for locally advanced non-small cell lung cancer (LA-NSCLC). We describe the incidence, time to development, presentation, management BMs after definitive chemoradiotherapy (CRT).We reviewed records patients with LA-NSCLC treated CRT within period from 2013 2020. Descriptive statistics were used characterize population Kaplan-Meier method was estimate BM. Fisher exact tests...
PurposeThis study investigates how isoform switching affects the cellular response to ionizing radiation (IR), an understudied area, despite its relevance radiotherapy in cancer treatment. We aimed identify changes transcript expression post-IR exposure and proteins mediating these changes, with a focus on their potential modulate radiosensitivity.MethodsUsing RNA sequencing, we analyzed B-cell lines derived from 10 healthy individuals at three timepoints, applying MISO algorithm quantify...
The ideal treatment paradigm for bulky diffuse large B-cell lymphoma (DLBCL) remains uncertain. We investigated the impact of tumor bulk in patients treated with systemic therapy alone through Alliance/CALGB 50303. Data from this trial were obtained National Cancer Institute's NCTN/NCORP Archive. study assessed size nodal sites and estimated progression-free survival (PFS) using Cox proportional hazards models. Stratified analysis factored International Prognostic Index (IPI) risk scores....
Introduction: Strategies for treatment of tonsil carcinoma are under active investigation. Limiting surgical and radiation volumes to the primary tumor ipsilateral neck in appropriately selected patients is one such approach. Here, we present our institutional experience with through or radiotherapeutic management. Methods: We retrospectively reviewed database treated from 2012 2020. Patients were included analysis if they received definitive therapy (RT), surgery (S), post-operative...