A5007767725- Lung Cancer Diagnosis and Treatment
- Advanced Radiotherapy Techniques
- Lung Cancer Research Studies
- Medical Imaging Techniques and Applications
- Head and Neck Cancer Studies
- Lung Cancer Treatments and Mutations
- Neuroendocrine Tumor Research Advances
- Radiomics and Machine Learning in Medical Imaging
- Advances in Oncology and Radiotherapy
- Brain Metastases and Treatment
- Cancer Immunotherapy and Biomarkers
- Radiology practices and education
- Meningioma and schwannoma management
- Innovations in Medical Education
- Cancer, Hypoxia, and Metabolism
- Cancer-related molecular mechanisms research
- Medical Imaging and Pathology Studies
- Inflammatory Biomarkers in Disease Prognosis
- Glioma Diagnosis and Treatment
- Colorectal and Anal Carcinomas
- Health and Medical Research Impacts
- Thyroid Cancer Diagnosis and Treatment
- Chromatin Remodeling and Cancer
- Advanced Neural Network Applications
- Medical Imaging and Analysis
SUNY Upstate Medical University
2010-2024
Upstate University Hospital
2024
Syracuse University
2024
Roswell Park Comprehensive Cancer Center
2016
Abstract Radiation therapy (RT) is a critical component of multidisciplinary cancer care, but has inconsistent curricular exposure. We characterize the radiation oncology (RO) content on standardized undergraduate medical examinations by comparing its context and prevalence with other domains in oncology. National Board Medical Examiners (NBME) self-assessments sample questions for United States Licensing Exam (USMLE) Steps 1–3 NBME clinical science shelf were accessed ( n = 3878). Questions...
TPS8123 Background: A minority of patients with unresectable stage III non-small cell lung cancer (NSCLC) may be cured by chemoradiotherapy (CRT). Adjuvant checkpoint inhibition through PD-L1 blockade after CRT improved survival compared to placebo in the PACIFIC trial (median progression-free (mPFS) 16.9 vs 5.6 months (mo), median overall (mOS) 47.5 29.1 mo), but at 5 years remains below 50% (Spigel D, et al J Clin Oncol 2022, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9015199/ . Only...
To report the outcomes of stereotactic body radiation therapy (SBRT) for stage I non-small-cell lung cancer (NSCLC) according to respiratory motion management method.Patients with NSCLC who received SBRT from 2007 2015 were reviewed. Computed tomography (CT) simulation four-dimensional CT was performed assessment. Tumor >1 cm in craniocaudal direction selectively treated advanced management: either gating a pre-specified portion cycle or dynamic tracking an implanted fiducial marker....
Positron-emission tomography (PET) has improved identification of the primary tumor as well occult nodal burden in cancer head and neck. Nevertheless, there are still patients where cannot be located. In these situations, standard care is comprehensive neck radiation therapy however it unclear whether this necessary. This study examines effects treatment volume on outcomes among using data from two centers unknown carcinoma neck.Patients received unilateral (n = 34), or bilateral 28)....
8504 Background: The CALGB 30610 trial demonstrated that 70Gy QD TRT was not associated with a superior overall survival compared to standard BID 45Gy in limited stage small cell lung cancer. Since both arms appeared provide similar clinical benefit, other factors such as quality of life may help oncologists decide on the best treatment approach for their patients. present analysis conducted compare patients’ between these regimens terms physical symptoms, functioning and psychological...
Virtual radiation oncology (RO) residency interviews may impair applicant and program evaluation. Second look events (SLEs) exist; however, the frequency, nature, implications are unknown. We surveyed applicants directors (PDs) to characterize 2023 RO Match SLEs assess perspectives.
The 2024 Brain Tumor Segmentation Meningioma Radiotherapy (BraTS-MEN-RT) challenge aims to advance automated segmentation algorithms using the largest known multi-institutional dataset of radiotherapy planning brain MRIs with expert-annotated target labels for patients intact or post-operative meningioma that underwent either conventional external beam stereotactic radiosurgery. Each case includes a defaced 3D post-contrast T1-weighted MRI in its native acquisition space, accompanied by...
Importance The impact of patient-specific, disease-related, and social factors on outcomes in limited-stage small cell lung cancer (LS-SCLC) is not well defined. A post hoc secondary analysis such from the Cancer Leukemia Group B (CALGB) 30610–Radiation Therapy Oncology (RTOG) 0538 trial may future design. Objective To assess comprehensive demographic, treatment-related, for potential associations with survival understand whether specific subpopulations benefit radiotherapy (RT) dose...
Abstract Background CALGB 30610 trial demonstrated that once daily thoracic radiotherapy (TRT) was not superior compared to standard twice TRT, in patients with limited stage small cell lung cancer. Quality of life outcomes may help oncologists decide the best treatment approach. Methods A total 417 on participated quality‐of‐life substudy (CALGB 70702), which included FACT Trial Outcome Index‐Lung Cancer (FACT‐L TOI), FACT‐Esophageal (FACT‐E) Eating and Swallowing Indices, ECOG Acute...
Over the past two decades, despite emergence of various novel therapies for glioblastoma, patient survival outcomes remain poor, particularly in recurrent stage disease. Cesium-131 (Cs-131) brachytherapy presents a promising treatment option patients with newly diagnosed and brain neoplasms, enabling initiation radiation therapy at time tumor resection. This approach eliminates typical delay following surgery need multiple return visits fractionated external beam radiotherapy. report...
9040 Background: Exon 19 deletions (del19) and L858R are classic activating EGFRm with sensitivity to approved tyrosine kinase inhibitors (TKIs). Recently, FDA-approval of afatinib was broadened include some more rare (S768I, L861Q, G719X) in addition del19/L858R. Methods: CGP performed on 34,328 NSCLCs, which 5,240 samples (15%; 4,592 tissue 648 blood-based ctDNA) from 4,872 patients (pts) were positive for short variant EGFRm. Pts profiled both pre- post-EGFR TKI included. Variants unknown...
8562 Background: PBRM1, of the SWI/SNF family, modulates chromatin remodeling. PBRM1 genomic alterations (GA) are enriched in renal cell carcinoma and mesothelioma (MS). Recent evidence suggests that GA strongly associated with neoantigen production responsiveness to immune checkpoint inhibitors (ICPI). Methods: Comprehensive profiling (CGP) was performed on 50 ng DNA for 783 FFPE (MS) samples using a hybrid-capture, adaptor ligation-based next-generation sequencing assay median coverage...
Prior studies suggest lymphopenia, systemic immune-inflammatory index, and tumor response all impact clinical outcomes in Stage III NSCLC. We hypothesized that after CRT would be associated with hematologic metrics might predict outcomes.Patients stage NSCLC treated at a single institution between 2011 2018 were retrospectively reviewed. Pre-treatment gross volume (GTV) was recorded then reassessed 1-4 months post-CRT. Complete blood counts before, during treatment recorded. Systemic...