A5055721473- Prostate Cancer Treatment and Research
- Advanced Proteomics Techniques and Applications
- Radiomics and Machine Learning in Medical Imaging
- Cancer, Lipids, and Metabolism
- Molecular Biology Techniques and Applications
- Prostate Cancer Diagnosis and Treatment
- Advanced Radiotherapy Techniques
- Glioma Diagnosis and Treatment
- Lung Cancer Diagnosis and Treatment
- Radiopharmaceutical Chemistry and Applications
- Lung Cancer Treatments and Mutations
- Metabolism, Diabetes, and Cancer
- Protein Kinase Regulation and GTPase Signaling
- Adrenal and Paraganglionic Tumors
- Pituitary Gland Disorders and Treatments
- Advanced Breast Cancer Therapies
- CRISPR and Genetic Engineering
- Bioinformatics and Genomic Networks
- Colorectal Cancer Treatments and Studies
- Advances in Oncology and Radiotherapy
- Cancer, Hypoxia, and Metabolism
- Pancreatic and Hepatic Oncology Research
- Computational Drug Discovery Methods
- Melanoma and MAPK Pathways
- Cancer Mechanisms and Therapy
University of California, Los Angeles
2023-2024
University of Colorado Denver
2024
University of Colorado Cancer Center
2024
University of Nebraska Medical Center
2016-2021
University of Nebraska at Omaha
2020
Nebraska Medical Center
2016-2020
St. Luke's Hospital
2019
Radiation Oncology Associates
2019
University of Nebraska–Lincoln
2011
<h3>Importance</h3> Currently, rates of referral patients with peritoneal metastasis in the United States who qualify for cytoreductive surgery combined hyperthermic intraperitoneal chemotherapy (CRS/HIPEC) are low, part because misperception high morbidity and mortality rates. However, requiring major gastrointestinal surgical procedures similar complication routinely referred. <h3>Objective</h3> To evaluate relative safety CRS/HIPEC. <h3>Design, Setting, Participants</h3> Retrospective...
The surrogacy of biochemical recurrence (BCR) for overall survival (OS) in localized prostate cancer remains controversial. Herein, we evaluate the BCR using different analytic methods.Individual patient data from 11 trials evaluating radiotherapy dose escalation, androgen deprivation therapy (ADT) use, and ADT prolongation were obtained. Surrogate candidacy was assessed Prentice criteria (including landmark analyses) two-stage meta-analytic approach (estimating Kendall's tau R2)....
A majority of breast cancer tumors express estrogen receptor (ER) and/or progesterone (PR); however, the percentage cells expressing these receptors can range from 0-100%. The prognostic and therapeutic impact hormone in is not fully understood.A retrospective analysis 411 patients who were treated at University Nebraska Medical Center between 2010 2017 was performed. Patient evaluated for ER PR conjunction with clinical outcomes.Patient demonstrated a highly bimodal pattern staining...
It has been shown that magnetic resonance imaging (MRI) guidance versus computed tomography (CT) for aggressive margin-reduction (AMR) stereotactic body radiotherapy (SBRT) in prostate cancer reduces acute toxicity, but the longer-term benefits are unknown. We performed a secondary analysis of MIRAGE, phase 3 randomized clinical trial MRI-guided SBRT cancer, to determine whether AMR with MRI significantly reduced 2-yr physician-scored or patient-reported toxic effects comparison CT guidance....
Background: Non-small cell lung cancer (NSCLC) is the most common form of and has a propensity to metastasize brain. It incredibly difficult distinguish between primary brain lesions solitary metastasis from distant occult disease using current imaging techniques. Further, complications arise shifting paradigm in how medicine views NSCLC due contemporary non-surgical curative treatments recent increase number multiple malignancy (MPM) diagnoses associated with NSCLC. There dearth reports...
KMT2/MLL proteins are commonly overexpressed or mutated in cancer and have been shown to support maintenance. These responsible for methylating histone 3 at lysine 4 promoting transcription DNA synthesis; however, they inactive outside of a multi-protein complex that requires WDR5. WDR5 has implicated its role the COMPASS interaction with Myc; colon not yet elucidated. expression was evaluated using RT-qPCR western blot analysis. Cell viability colony forming assays were utilized evaluate...
The cell cycle is under circadian regulation. Oncogenes can dysregulate circadian-regulated genes to disrupt the cycle, promoting tumor proliferation. As a regulator of G2/M arrest in response DNA damage, gene Timeless Circadian Clock (TIMELESS) coordinates this connection and potential locus for oncogenic manipulation. TIMELESS expression was evaluated using RNASeq data from TCGA by RT-qPCR western blot analysis panel colon cancer lines. following ERK inhibition examined via blot. Cell...
<ns4:p>Many cancers, including those of the colon, lung, and pancreas, depend upon signaling pathways induced by mutated constitutively active Ras. The molecular scaffolds Kinase Suppressor Ras 1 2 (KSR1 KSR2) play potent roles in promoting Ras-mediated through Raf/MEK/ERK kinase cascade. Here we summarize canonical role KSR cells, its central as a scaffold protein for cascade, regulation various cellular mediated different binding partners, phenotypic consequences KSR1 or KSR2 genetic...
Kinase Suppressor of Ras 2 (KSR2) is a molecular scaffold coordinating Raf/MEK/ERK signaling that expressed at high levels in the brain. KSR2 disruption humans and mice causes obesity insulin resistance. Understanding anatomical location mechanism function should lead to better understanding physiological regulation over energy balance. Mice bearing floxed alleles (KSR2fl/fl) were crossed with expressing Cre recombinase by Nestin promoter (Nes-Cre) produce Nes-CreKSR2fl/fl mice. Growth, body...
Abstract Radiation therapy (RT) is a critical component of multidisciplinary cancer care, but has inconsistent curricular exposure. We characterize the radiation oncology (RO) content on standardized undergraduate medical examinations by comparing its context and prevalence with other domains in oncology. National Board Medical Examiners (NBME) self-assessments sample questions for United States Licensing Exam (USMLE) Steps 1–3 NBME clinical science shelf were accessed ( n = 3878). Questions...
DNA sequencing continues to get cheaper and faster. In parallel, algorithmic innovations have allowed inference of a wide range nuclear, mitochondrial, somatic evolutionary from data. To make automated, high-quality more readily available, we created an extensible Nextflow meta-pipeline called metapipeline-DNA. Metapipeline-DNA supports processing raw reads through alignment, variant detection, quality control subclonal reconstruction. Each step quality-control, data-visualization multiple...
Colorectal cancer (CRC) remains one of the leading causes related deaths in United States. Currently, there are limited therapeutic options for patients suffering from CRC, none which focus on cell signaling mechanisms controlled by popular kinase family, cyclin dependent kinases (CDKs). Here we evaluate a Pfizer developed compound, CP668863, that inhibits cyclin-dependent 5 (CDK5) neurodegenerative disorders. CDK5 has been implicated number cancers, most recently as an oncogene colorectal...
Background: Despite the fact that stereotactic body radiation therapy (SBRT) is only recommended first-line for inoperable early-stage non–small cell lung cancer (NSCLC), several thermal ablative procedures (TAPs; defined herein as laser/cryoablation and electrocautery) are available. Studies showing outcomes of these how they compare with SBRT scarce. We sought to evaluate comparative efficacy versus TAPs using National Cancer Database (NCDB). Methods: The NCDB was queried patients NSCLC...
AMPK is a serine threonine kinase composed of heterotrimer catalytic, kinase-containing α and regulatory β γ subunits. Here we show that individual subunit expression requirement for survival varies across colon cancer cell lines. While AMPKα1 relatively consistent lines, depletion does not induce death. Conversely, AMPKα2 expressed at variable levels in cells. In high expressing SW480 moderate HCT116 cells, siRNA-mediated induces These data suggest inhibition may be useful component future...
Prostate cancer is frequently treated with radiotherapy. Unfortunately, aggressive radioresistant relapses can arise, and the molecular underpinnings of radioresistance are unknown. Modern clinical radiotherapy evolving to deliver higher doses radiation in fewer fractions (hypofractionation). We therefore analyzed genomic, transcriptomic, proteomic data characterize prostate cells both conventionally fractionated hypofractionated Independent fractionation schedule, resistance involved...