A5101987959- Genetic factors in colorectal cancer
- Colorectal Cancer Treatments and Studies
- PI3K/AKT/mTOR signaling in cancer
- Cancer, Hypoxia, and Metabolism
- Cancer Genomics and Diagnostics
- Colorectal Cancer Screening and Detection
- Diet and metabolism studies
- Liver Disease Diagnosis and Treatment
- Global Cancer Incidence and Screening
- Cancer Mechanisms and Therapy
- Cancer, Lipids, and Metabolism
- TGF-β signaling in diseases
- Pancreatic and Hepatic Oncology Research
- Cancer-related Molecular Pathways
- Lung Cancer Treatments and Mutations
- Cancer-related gene regulation
- Cancer Research and Treatments
- Growth Hormone and Insulin-like Growth Factors
- Epigenetics and DNA Methylation
- Adipose Tissue and Metabolism
- Cancer Cells and Metastasis
- Gastric Cancer Management and Outcomes
- Melanoma and MAPK Pathways
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Metabolomics and Mass Spectrometry Studies
National Institute of Cardiovascular Diseases
2012-2025
University of Nebraska Medical Center
2009-2025
Janssen (United States)
2024
Verastem (United States)
2021-2022
University Medical Center
2016-2020
Boston University
2016-2020
Boston Medical Center
2016-2020
National Institute of Cardiovascular Diseases
2017
Nebraska Medical Center
2009
The University of Texas Health Science Center at San Antonio
2009
The aim of this study is to describe the trends and variations in global burden colorectal cancer (CRC).Data (2012-2030) relating CRC was extracted from GLOBOCAN 2012 database analyzed.The results our demonstrate a rising which persists until year 2035 likely beyond. rise not uniform with significant influenced by geographic location, socio-economic status, age, gender. Although EURO region has highest burden, Asia as continent continues bear heaviest brunt disease. disease higher more...
Gallbladder cancer (GBC) is a rare but lethal malignancy with dismal prognosis. The aim of this study to analyze the burdens and trends GBC across world based on geography, socioeconomic development (based human index [HDI]), gender.GLOBOCAN 2020 database was used extract data (2020-2040) relating incidence mortality world.Asia had highest burden India China contributing majority absolute burden. by age standardized rate in Latin America (Bolivia Chile) Southeast Asia (Bangladesh Nepal)....
Abstract Background There is extensive evidence for the role of aberrant cell survival signaling mechanisms in cancer progression and metastasis. Akt a major component survival-signaling several types cancer. It has been shown that activated stabilizes XIAP by S87 phosphorylation leading to survivin/XIAP complex formation, caspase inhibition cytoprotection cells. We have reported TGFβ/PKA/PP2A-mediated tumor suppressor regulates association with dissociation complexes stress-dependent...
BACKGROUND The aim of this study is to describe the trends and variations in global burden gallbladder cancer (GBC) with an emphasis on geographic female gender. METHODS Data (2012‐2030) relating GBC was extracted from GLOBOCAN 2012 database analyzed. RESULTS results our document a rising gender variations. highest noted WPRO region (based WHO regions), Asia continents) India, Chile, China countries). less developed regions world account for majority GBC. are also present within individual...
Pancreatic Cancer (PC) is a lethal malignancy that accounts for about 4% of cancer-related deaths worldwide. The aim this study to describe the influence geography (based on WHO regions), socio-economic development Human Development Index [HDI]) and demographic shift temporal trends in global incidence mortality PC.Data (2012-2030) relating incidence, PC shifts based regions HDI areas were extracted from GLOBOCAN 2012. Linear regression was used evaluate total mortality.We noted definite...
197 Background: Amivantamab (ami) is an EGFR-MET bispecific antibody with immune cell-directing activity and FDA approved in EGFR -mutated advanced non-small cell lung cancer. High MET expression observed ~68% of patients (pts) metastatic colorectal cancer (mCRC). Additionally, amplification occurs up to 23% EGFR-resistant mCRC implicated driving resistance EGFR-targeting antibodies (EGFRi). Compared left (L)-sided disease, right (R)-sided disease less responsive EGFRi associated poorer...
Background: In-hospital cardiac arrest (IHCA) is a common clinical event with extremely poor outcomes associated cardiovascular disease. Although IHCA, high mortality rate, has received little attention compared to other conditions such as myocardial infarction and stroke [1]. The survival rate of IHCA discharge approximately 25% [2]. We report case in patient history old MI (anterior), SVD, uncontrolled DM HTN. was initially treated resuscitation according guidelines due the unavailability...
Colorectal cancer (CRC) is the second leading cause of cancer-related mortality in United States. There an increasing need for identification biomarkers pre-malignant and early stage CRC to improve risk-stratification screening recommendations. In this study, we investigated possibility metabolic mitochondrial reprogramming colorectal field.Rectal biopsies were taken from 81 patients undergoing colonoscopy, gene expression markers assessed using real time quantitative PCR. Validation studies...
The aim of this study is to describe the influence geography, socio-economic development, and demographic shift on trends in global incidence, mortality, prevalence liver cancer (LC).Data (2012-2030) relating LC shifts based WHO regions HDI areas were extracted from GLOBOCAN 2012 analyzed evaluate prevalence.The results our document a rising burden with maximum impact WPRO region. We did not observe definite association between higher status highest MHD For region, we noticed age reversal...
Background Understanding drivers for metastasis in human cancer is important potential development of therapies to treat metastases. The role loss TGFβ tumor suppressor activities the metastatic process essentially unknown. Methodology/Principal Findings Utilizing vitro and vivo techniques, we have shown that signaling necessary allow last step - colonization site. This work demonstrates first time receptor reconstitution leads decreased colonization. Moreover, identified a novel TGFβ/PKA...
In this study, we have uncovered a novel crosstalk between TGFβ and IGF-1R signaling pathways. We show for the first time that expression activation of IRS-1, an adaptor protein, is decreased by TGFβ/Smad3 signaling. Loss or attenuation leads to elevated phosphorylation IRS-1 in colon cancer cells, resulting enhanced cell proliferation, apoptosis increased tumor growth vitro vivo. Downregulation reversed Smad3 knockdown-mediated oncogenic phenotypes, indicating inhibits proliferation...
Mutations in the gene Adenomatous Polyposis Coli or APC appear most sporadic cases of colorectal cancer and it is frequent mutation causing hereditary Familial Polyposis. The detailed molecular mechanism by which mutations predispose to development not completely understood. This part due lack accessibility appropriate models that recapitulate early events associated with mediated intestinal transformation. We have established a novel platform utilizing human induced Pluripotent Stem cells...
135 Background: Amivantamab (ami), an EGFR-MET bispecific antibody with immune cell-directing activity, has shown preclinical activity in colorectal cancer (CRC) models. MET amplification is implicated driving resistance to anti-EGFR therapies metastatic CRC (mCRC). We hypothesize that dual, co-inhibition of EGFR and ami could improve outcomes relapsed/refractory mCRC. Methods: OrigAMI-1 (NCT05379595) assessing the safety efficacy as monotherapy patients (pts) refractory mCRC 3 separate...
363 Background: Amivantamab (Ami) is a bispecific antibody targeting epidermal growth factor receptor (EGFR) and mesenchymal epithelial transition (Met) has immune cell directing activity. Gastric cancer (GC), gastroesophageal junction (GEJ) esophageal (EC) have been known to express EGFR Met these expressions correlated with poor prognosis. Methods: This open-label, multicenter phase 2 study aims evaluate the antitumor activity safety of Ami monotherapy in patients (pts) advanced or...
Survivin is a cancer-associated gene that functions to promote cell survival, division, and angiogenesis marker of poor prognosis. Histone deacetylase inhibitors induce apoptosis re-expression epigenetically silenced tumor suppressor genes in cancer cells. In association with increased expression the transforming growth factor β receptor II (TGFβRII) induced by histone inhibitor belinostat, we observed repressed survivin expression. We investigated molecular mechanisms involved...
Core 3-derived glycans, a major type of O-glycan expressed by normal epithelial cells the gastrointestinal tract, are downregulated during malignancy because loss expression functional β3-N-acetylglucosaminyltransferase-6 (core 3 synthase). We investigated core synthase in pancreas and pancreatic cancer evaluated biological effects re-expressing that had lost expression. determined tumors tumor cell lines have synthase. Therefore, we re-expressed human (Capan-2 FG) to investigate...
Background Colorectal cancer (CRC) metastasis is a leading cause of cancer-related deaths in the United States. The molecular mechanisms underlying this complex, multi-step pathway are yet to be completely elucidated. Recent reports have stressed importance intra-tumoral heterogeneity development metastatic phenotype. purpose study was characterize phenotypic between two iso-clonal human colon sublines HCT116 and HCT116b on their ability undergo colonization survive under growth factor...