Timothy Sanders
A5030825676- COVID-19 Clinical Research Studies
- PARP inhibition in cancer therapy
- SARS-CoV-2 and COVID-19 Research
- Genetics and Neurodevelopmental Disorders
- Genomics and Phylogenetic Studies
- COVID-19 and healthcare impacts
- CRISPR and Genetic Engineering
- RNA modifications and cancer
- COVID-19 Impact on Reproduction
- RNA and protein synthesis mechanisms
University of California, Los Angeles
2022-2024
Stanford University
1982
Defense Intelligence Agency
1982
National Aeronautics and Space Administration
1982
U.S. National Science Foundation
1982
National Security Agency
1982
The Ohio State University
1982
DNA sequencing continues to get cheaper and faster. In parallel, algorithmic innovations have allowed inference of a wide range nuclear, mitochondrial, somatic evolutionary from data. To make automated, high-quality more readily available, we created an extensible Nextflow meta-pipeline called metapipeline-DNA. Metapipeline-DNA supports processing raw reads through alignment, variant detection, quality control subclonal reconstruction. Each step quality-control, data-visualization multiple...
Coronavirus disease 2019 (COVID-19) has exposed health care disparities in minority groups including Hispanics/Latinxs (HL). Studies of COVID-19 risk factors for HL have relied on county-level data. We investigated using individual-level, electronic records a Los Angeles system between March 9, 2020, and August 31, 2020. Of 9,287 tested SARS-CoV-2, 562 were positive. constituted an increasing percentage all positive individuals as severity escalated. Multiple identified Non-Hispanic/Latinx...
Abstract Host genetics is a key determinant of COVID-19 outcomes. Previously, the Genetics Initiative genome-wide association study used common variants to identify multiple loci associated with However, largest impact on outcomes are expected be rare in population. Hence, studying may provide additional insights into disease susceptibility and pathogenesis, thereby informing therapeutics development. Here, we combined whole-exome whole-genome sequencing from 21 cohorts across 12 countries...
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