A5039080856- Synthesis and biological activity
- NF-κB Signaling Pathways
- Cancer-related Molecular Pathways
- Cell death mechanisms and regulation
- Graphene and Nanomaterials Applications
- Endoplasmic Reticulum Stress and Disease
- Advanced Breast Cancer Therapies
- Synthesis and Characterization of Heterocyclic Compounds
- Ubiquitin and proteasome pathways
- Protein Degradation and Inhibitors
- Nanoparticle-Based Drug Delivery
- Synthesis and Biological Evaluation
- Cancer therapeutics and mechanisms
- Synthesis and bioactivity of alkaloids
- Agriculture and Farm Safety
- Multicomponent Synthesis of Heterocycles
- Advanced Drug Delivery Systems
- Multiple Myeloma Research and Treatments
- Plant Pathogens and Fungal Diseases
- Magnetic and Electromagnetic Effects
- Temporomandibular Joint Disorders
- Melanoma and MAPK Pathways
- Quinazolinone synthesis and applications
- Mitochondrial Function and Pathology
- Identification and Quantification in Food
University of Nebraska Medical Center
2017-2022
Sher-e-Kashmir University of Agricultural Sciences and Technology of Jammu
2020
Nebraska Medical Center
2017-2020
Indian Institute of Integrative Medicine
2013-2016
Academy of Scientific and Innovative Research
2013-2014
University of Jammu
2013
Institute of Minerals and Materials Technology
1984
In this manuscript, for the first time, we report synthesis of a PROTAC that selectively degrades cyclin dependent kinase 9 (CDK9).
Colorectal cancer (CRC) remains one of the leading causes related deaths in United States. Currently, there are limited therapeutic options for patients suffering from CRC, none which focus on cell signaling mechanisms controlled by popular kinase family, cyclin dependent kinases (CDKs). Here we evaluate a Pfizer developed compound, CP668863, that inhibits cyclin-dependent 5 (CDK5) neurodegenerative disorders. CDK5 has been implicated number cancers, most recently as an oncogene colorectal...
Developing small molecules that indirectly regulate Mcl-1 function has attracted a lot of attention in recent years. Here, we report the discovery an aminopyrazole, 2-([1,1′-biphenyl]-4-yl)-<i>N</i>-(5-cyclobutyl-1<i>H</i>-pyrazol-3-yl)acetamide (analog 24), which selectively inhibited cyclin-dependent kinase (CDK) 5 over CDK2 cancer cell lines. We also show analog 24 reduced levels concentration-dependent manner Using panel doxycycline inducible lines, CDK5 inhibitor modulates while CDK4/6...
The unfolded protein response (UPR) is an adaptation mechanism activated to resolve transient accumulation of unfolded/misfolded proteins in the endoplasmic reticulum. Failure such results UPR-mediated programmed cell death. Loss tumor suppressor gene or oncogene addiction cancer cells can result sustained higher basal UPR levels; however, it not clear if these levels be exploited as a therapeutic strategy. We hypothesized that covalent modification surface-exposed cysteine (SEC) residues...
Significance Pancreatic cancer is a deadly disease with limited therapeutic options. High expression of the kinase MAP3K1 associated poor survival among pancreatic patients. activates IKKβ, and our studies show that higher levels activated IKKβ are found in patient-derived tumors as opposed to surrounding normal tissue. We also inhibition by drug-like compound 39-100 results reduced IKKβ. This leads tumor growth metastasis models. Therefore, drug candidates like 39-100, activation...
The release of an active drug from the prodrug generates a pro-fragment that typically has no biological activity and could result in adverse effects. By combining two drugs, wherein each acts as other will eliminate prodrug. As they are prodrugs symbiotic, we termed these symbiotic (SymProDs). To test this idea, generated SymProDs using NFκB inhibitors contain reactive α-methylene-γ-butyrolactone moiety CDK with solvent exposed secondary nitrogen atoms. We show amine containing undergo slow...
Tumor necrosis factor (TNF) α-induced nuclear translocation of the NF-κB subunit RELA has been implicated in several pathological conditions. Here we report discovery a spirocyclic dimer (SpiD7) that covalently modifies to inhibit TNFα-induced translocation. This is previously unexplored strategy activation.
Anterior crowding/ spacing are one of the major problems that inspire patients to undergo orthodontic treatment. Several factors associated with anterior includes arch width and length, mesio-distal tooth diameter proportions. The aim present study was evaluate relationship maxillary mandibular base lengths amount dental in complete class II malocclusions.A retrospective done 152 who were divided into four groups according severity pre-treatment crowding/spacing arch. Measurements performed...
The present study was aimed to understand the prevalence of heifer mastitis and its associated risk factors in Jammu region.A total 250 pregnant heifers (1000 quarters) were screened, lacteal secretions collected from 915 quarters individually, order estimate by culturing.The estimated based on results microorganism culture.The overall 90.80% cultural examination whereas only 30% animals produced clinical signs.The higher organized management system prime with season calving, prepartum...
Abstract 14 Title compounds of type (V) are prepared and tested for their antiproliferative apoptosis‐inducing activities.