A5055093301- Nanoparticle-Based Drug Delivery
- RNA Interference and Gene Delivery
- Advanced biosensing and bioanalysis techniques
- Advanced Drug Delivery Systems
- Graphene and Nanomaterials Applications
- Nanoplatforms for cancer theranostics
- Lanthanide and Transition Metal Complexes
- Magnetic properties of thin films
- Iron oxide chemistry and applications
- Analytical Chemistry and Sensors
- Magnetic Properties and Synthesis of Ferrites
- Dendrimers and Hyperbranched Polymers
- Advancements in Transdermal Drug Delivery
- Cancer Treatment and Pharmacology
- Dermatology and Skin Diseases
- Acne and Rosacea Treatments and Effects
Indian Institute of Technology Delhi
2015-2018
All India Institute of Medical Sciences
2016-2018
Indian Institute of Integrative Medicine
2014-2015
The study highlights the significance of co-application bioactive components into liposomal gel formulations and their comparison to azithromycin for treatment Acne. A Design Experiments (DoE) approach was utilized obtain optimized formulation encapsulating curcumin, with size zeta potential ∼100 nm ∼14 mV, respectively, characterized by DLS, HR-TEM, FESEM, AFM. curcumin dispersion depicted excellent stability over period 60 days, which further converted in form using Carbopol....
To overcome the limitations of conventional chemotherapy, nanoparticle-mediated combinatorial delivery siRNA and drugs represents a new approach to its associated side effects. Designing safe efficient vehicles for their codelivery has emerged as potential challenge in clinical translation these formulations. Herein, we have demonstrated novel "two-in-one" polyplex nanosystem developed from redox sensitive, short chain polyethylenimine modified poly[(poly(ethylene)glycol...
In the present work, polymersomes based on self-assembled, folate-targeted, redox-responsive, ATRP-based amphiphilic diblock copolymer poly(polyethylene glycol)-S-S-polylactide with disulfide linkage were developed for efficient doxorubicin (DOX) delivery and compared marketed DOXIL nanoformulation. The formulation was optimized by quality design approach providing monodisperse nanostructures of ∼110 nm enhanced DOX loading ∼20%. Polymersomes showed excellent stability as per ICH guidelines...
In the present investigation, potential of a novel, self-assembled, biocompatible, and redox-sensitive copolymer system with disulfide bond was explored for doxorubicin (DOX) delivery through polymersome nanostructures ∼120 nm. The polymer synthesized less steps, providing high yield 86%. developed polymersomes showed admirable biocompatibility dose tolerability in vitro vivo. colloidal stability DOX-loaded depicted stable uniform particle size over period 72 h. cellular internalization...
The anti-apoptotic defense mechanism of cancer cells poses a major hurdle which makes chemotherapy less effective. Combinatorial delivery drugs and siRNAs targeting proteins is vital means for improving therapeutic effects. present study aims at designing suitable carrier can effectively co-deliver doxorubicin plk1 siRNA to tumor cells. Low molecular weight poly(styrene-alt-maleic anhydride) was chemically modified via click reaction obtain cationic amphiphilic polymer the co-delivery...