ConspectusSpherical ordering from small molecules is a subject of intense interest to chemists. The inherent capability amphiphiles assemble spontaneously the unique feature evolutionary process life. Self-assembly prevalent in biology and has attracted scientists across several disciplines. This because have realized that nature extensively used this organizational power contained molecules. Judicious use self-assembly principle cornerstone nature's exotic assemblies. These assemblies lead...

The chemical understanding of biological processes provides not only a deeper insight but also solution to abnormal functioning. Protein degradation, natural process for debris removal in the cell, has been studied years. recent finding that degradation pathways can be utilized therapeutic purposes is paradigm shift drug discovery approach. Methods such as Proteolysis Targeting Chimera (PROTAC), lysosomal targeting chimera, hydrophobic tagging, AUtophagy TArgeting Chimera, AUTOphagy and...

Urea-cored pseudopeptides exhibit remarkable self-assembly to varying morphologies. Concentration-dependent studies revealed a series of morphological transformations from vesicles toroids, and honeycomb-like architectures. The morphology dependent autofluorescence is another noteworthy observation.

A variety of 18-membered cyclodepsipeptides with alternating repeats aromatic (phenyl or pyridyl) and Ser units in the ring have been synthesized studied by X-ray crystallography for self-assembly patterns. Single-crystal structures macrocycles showed similar, relatively flat-ring structures. Those molecules containing one two pyridine stacking over other, thus creating tubular using π−π interactions between Ph/Pyr Pyr/Pyr as main organizing force. The cylindrical stacks are further...

The synthesis and single-crystal X-ray structures of hydrogen squarates imidazole (1), histidine (2), 2-aminopyridine (4) (3) 4-aminopyridine (5) are reported. Both squarate [HSQ]1- [SQ]2- ions participate in complementary bonding [X−H···O; X = N, O, or C] networks. While the ion acts both as a donor an acceptor bonds salts 1, 2, 4 creates head-to-tail infinite chains anions 1 head-to-head ten-membered cyclic dimers 4, participates powerful many six 3 5. In all cases, extensive ionic...

A series of novel triazolophanes containing peptidic and nonpeptidic backbones is reported. The crystal structure one such macrocycle displays self-assembly through nonconventional hydrogen-bonding interactions.

Anion receptors have attracted growing interest because of their role in chemistry, the environment, biology and medicine. The mis-regulation anion flux causes a variety lethal human diseases. Recently, triazole has been found to be an excellent motif for molecular recognition. This review depicts overall picture developments design synthesis along with up-to-date emphasis on unit as acidic CH is involved binding anions, which makes these different from other classes receptors. chemo-...

Background Japanese encephalitis virus (JEV) is a major cause of viral in South and South-East Asia. Lack antivirals non-availability affordable vaccines these endemic areas are setback combating JEV other closely related viruses such as West Nile dengue virus. Protein secondary structure mimetics excellent candidates for inhibiting the protein-protein interactions therefore serve an attractive tool drug development. We synthesized derivatives containing backbone naturally occurring lupin...

Gene silencing by RNA interference is a powerful technology with broad applications. However, this has been hampered the instability of small interfering (siRNA) molecules in physiological conditions and their inefficient delivery into cytoplasm target cells. Porous silicon nanoparticles have emerged as potential vehicle to overcome these limitations—being able encapsulate within porous matrix protect them from degradation. Here, key variables were investigated that influence siRNA loading...

Here we delineate simple and tunable hydrophobically driven chiral functional assemblies of diacetylene cored pseudopeptides. These amino acid appended, rigid core dialkynes constitute promising supramolecular building blocks for materials properties engineering. The appended elements allow tuning solubility interaction as well governing chirality, while the central dialkyne can impart assembly Aggregation Induced Emission (AIE) properties. self-assembly these rod-like be regulated by...

Abstract The structural dynamics involved in the mechanical flexibility of molecular crystals and internal stress such flexible materials remain obscure. Here, study reports an elastically bending lipidated crystal that shows systematic shifts characteristic vibrational frequencies across bent region – revealing nature changes during local distribution. blueshifts bond stretching modes (such as C═O C−H modes) inner arc redshifts outer observed via micro‐Raman mapping are counterintuitive to...

In the present work, polymersomes based on self-assembled, folate-targeted, redox-responsive, ATRP-based amphiphilic diblock copolymer poly(polyethylene glycol)-S-S-polylactide with disulfide linkage were developed for efficient doxorubicin (DOX) delivery and compared marketed DOXIL nanoformulation. The formulation was optimized by quality design approach providing monodisperse nanostructures of ∼110 nm enhanced DOX loading ∼20%. Polymersomes showed excellent stability as per ICH guidelines...

A novel family of aromatic-bridged cystine cyclic peptides (cystinophanes) has been synthesized by a single-step procedure involving condensation 1,3 aromatic (Ph or Pyr unit) dicarbonyl dichloride with either the simple l-cystine dimethyl ester to provide cystinophanes 26-, 39-, and 52-membered rings through 2+2, 3+3, 4+4 cyclization, respectively, bis-peptides (H2N-Xaa-Cyst-Xaa-NH2) leading variety 1+1 cystine-based peptidocyclophanes. 1H NMR CD studies have shown these adopt β-turn-like...

Abstract Helix mimetics are good models for investigating the theories of protein folding and also act as affinity ligands therapeutic applications due to their biostability better blood‐brain barrier crossing ability. The helix display same spatial temporal orientation with respect amino acid side‐chains alpha part protein, which involved in protein–protein interactions. designed nonpeptidic molecules substituents at appropriate positions on scaffold can mimic a fully folded competitively...

We report on the self-assembly based fabrication of fibrous polymers for tissue engineering applications. Directed followed by polymerization lysine-appended diacetylenes generated a variety (P1-P5) with distinct chemical properties. The along conjugated double and triple bonds rigid geometry diacetylene backbone imposed nanofibrous morphology resulting polymers. Chemical properties including wettability were tuned using lysine (Lys) orthogonal protecting groups (Boc Fmoc). These...

The rational design and synthesis of molecules with functional supramolecular assemblies continues to be a challenging endeavor. Self-assembled nano- microstructures from natural building blocks are considered more appropriate for medical applications due their biocompatible nature. We report the first time simple redox-responsive dipeptide that self-assembles form vesicles in aqueous medium. experimental results based on control compound all-atom molecular dynamics (MD) simulations support...

Syntheses and crystal structures of 1,3-bis[(pyrid-2-ylamino)carbonyl]adamantane (1) its perchlorate salt, copper(II) complex, 1:1 complexes with a large variety simple functionalized 1,ω-alkanedicarboxylic acids, HOOC−X−COOH [X = (CH2)n, n 2, 3, 5, 8; −CH2−CO (α-ketoglutaric acid); CHCH (maleic acid)] are described. The molecule 1 exhibits remarkable adaptability respect to the conformation two hydrogen-bonding subunits suit requirements assembling partners so as generate persistently...

A novel family of hairpin cyclic peptides has been designed on the basis use norbornene units as bridging ligands. The design is flexible with respect to choice an amino acid, ring size, and nature second ligand illustrated here preparation a large number norborneno containing variety acids in sizes varying from 12- 29-membered, being rigid (11, 13a,b), adamantane unit (7a,b 8), or cystine residue (4a,b 10). presence built-in handles (as protected COOH groups) permits attachment subunits...

endo-cis-(2S,3R)-Bicyclo[2.2.1]hept-5-en (norbornene) dicarbonyl unit with a built-in U-architecture has been demonstrated to be an excellent reverse-turn molecular scaffold. A large variety of endo-cis-(2S,3R)-norborneno bispeptides containing almost all the coded amino acids were synthesized and examined for conformational preferences by 1H NMR, FT-IR, CD, X-ray crystallographic studies. While FT-IR NMR variable-temperature studies ruled out presence any significant amount intramolecular...

A 33-residue de novo designed peptide ligase is reported which catalyzes the template-directed condensation of suitably activated short peptides with catalytic efficiencies in excess 105 ([kcat/Km]/kuncat). The peptide, derived from natural and α-helical coiled-coil proteins, presents a surface for substrate assembly via formation hydrophobic core at interface. Charged residues flanking provide additional binding specificity through electrostatic complementarity. Addition template to an...