A5060685591- Natural product bioactivities and synthesis
- Microbial Natural Products and Biosynthesis
- Bioactive Compounds and Antitumor Agents
- Phytochemical compounds biological activities
- Synthesis and biological activity
- Chemical Synthesis and Analysis
- Phytochemistry and Biological Activities
- Pharmacological Effects of Natural Compounds
- Bioactive natural compounds
- Prostate Cancer Treatment and Research
- Essential Oils and Antimicrobial Activity
- Chemical Synthesis and Reactions
- Plant biochemistry and biosynthesis
- Synthesis of Organic Compounds
- Plant chemical constituents analysis
- Computational Drug Discovery Methods
- SARS-CoV-2 and COVID-19 Research
- Prostate Cancer Diagnosis and Treatment
- Advanced Synthetic Organic Chemistry
- Biological Activity of Diterpenoids and Biflavonoids
- Metabolomics and Mass Spectrometry Studies
- Cancer therapeutics and mechanisms
- Phytochemistry and Bioactivity Studies
- Nanomaterials for catalytic reactions
- Phytochemistry and Bioactive Compounds
Banaras Hindu University
2019-2025
Indian Institute of Technology BHU
2019-2025
Indian Institute of Technology Indore
2001-2024
Georgetown University Medical Center
2018-2024
Georgetown University
2018-2024
Indian Institute of Integrative Medicine
2012-2022
Academy of Scientific and Innovative Research
2013-2022
Lovely Professional University
2022
Asian Development Bank Institute
2020
Guru Gobind Singh Indraprastha University
2020
Curcumin and osthol are identified as NorA pump inhibitors.
Rohitukine (1), a chromone alkaloid isolated from Indian medicinal plant Dysoxylum binectariferum, has inspired the discovery of flavopiridol and riviciclib, both which are bioavailable only via intravenous route. With objective to address oral bioavailability issue this scaffold, four series rohitukine derivatives were prepared screened for Cdk inhibition cellular antiproliferative activity. The 2,6-dichloro-styryl derivative IIIM-290 (11d) showed strong Cdk-9/T1 (IC50 1.9 nM) kinase...
In this recent investigation, the focus centred on exploring potential phytoconstituents within bark of Dysoxylum malabaricum. A profiling strategy employing LC-HRMS (Liquid Chromatography-High Resolution Mass Spectrometry) was implemented for rapid identification compounds from extract. The crude extract underwent fractionation, resulting in isolation four previously known (1–4) and a novel cycloartane triterpenoid named Mahamanalactone (5). Compound 5 represents with modified ring-A,...
Profiling the extracts using LC-HRMS is now a standard and powerful method to search for new metabolites drug discovery. generates long list of mass (m/z) values, and...
Dysoxylum malabaricum is well-known as a folklore herb. It extensively utilized in traditional medicine to address various ailments. The study investigated the phytochemicals of D.malabaricum, focusing on its fruit, which was found contain terpenoids. Through extensive spectral analysis, 6 triterpenoids and 1 limonoid were identified reported for first time. cytotoxicity compound evaluated through in-vitro in-silico studies followed by MD simulations. Extracts prepared chromatographic...
An efficient and eco-friendly synthesis of therapeutically important structurally diverse imidazo[1,2-a]pyridines using recyclable bimetallic Cu–Mn spinel oxide catalyst in aqueous medium has been developed. The catalyzed domino three-component coupling 2-aminopyridines, aldehydes alkynes followed by 5-exo-dig cycloisomerization produced desired good yields. efficiency this protocol could be attributed to the presence these metals multiple oxidation states (Cu2+, Mn2+, Mn3+ Mn4+) catalyst....
3CL like protease (3CLpro or Mpro) is one of the main proteases 2019-nCoV. The 3CLpro a nonstructural protein SARS-CoV and has an essential role in viral replication transcription, thus, could be potential target for anti-SARS drug development. present study employed ligand- structure-based approaches to identify potent inhibitors 2019-nCoV protease. e-pharmacophore developed from 3CLpro-1 yielded virtual hits, that were subjected through likeliness PAINS filters remove interfering...
Abstract The continuous emergence of antimicrobial resistance (AMR) is a serious threat to humans. discovery and development new antibiotics having modes action are the global need save mankind. Natural products (NPs) have played central role in drug discovery. Although biologically active, natural pose some critical issues their therapeutic uses, including supply issues, pharmacokinetic properties, resistance, toxicity. Semisynthesis holds promise antibiotics, offering strategic approach...
To explore the potential of Rosellinia sanctae-cruciana an endophytic fungus associated with Albizia lebbeck for pharmaceutically important cytotoxic compounds.One novel cytochalasin, named jammosporin A (1) and four known analogues (2-5) were isolated from culture R. sanctae-cruciana, harboured leaves medicinal plant A. lebbeck. Their structures elucidated by extensive spectroscopic analyses including one-dimensional two-dimensional nuclear magnetic resonance data along MS comparison...
The availability of robust classification algorithms for the identification high risk individuals with resectable disease is critical to improving early detection strategies and ultimately increasing survival rates in PC. We leveraged quality biospecimens extensive clinical annotations from patients that received treatment at Medstar-Georgetown University hospital. used a resolution mass spectrometry based global tissue profiling approach conjunction multivariate analysis developing...
Rapid assessment of radiation signatures in noninvasive biofluids may aid assigning proper medical treatments for acute syndrome (ARS) and delegating limited resources after a nuclear disaster. Metabolomic platforms allow rapid screening biofluid show promise differentiating quality time postexposure. Here, we use global metabolomics to differentiate temporal effects (1-60 d) found nonhuman primate (NHP) urine serum small molecule 4 Gy total body irradiation. Random Forests analysis...
Abstract Psoralea corylifolia (syn. Cullen corylifolium ), commonly called bawachi, is a medicinal plant extensively used for skin conditions like leukoderma, vitiligo, and psoriasis. It notably rich in valuable bioactive compounds, particularly coumarins furanocoumarins. This study isolated fourteen from P. which were tested cytotoxicity using the MTT assay, with compound 10 showing good against A549 cells (IC 50 0.9 μM), while 1 , 2 3 displaying potential MDA‐MB‐231 0.49 μM, 0.56 0.84 μM...
New cycloartane triterpenoids (2–4) have been recently discovered in the bark of Dysoxylum malabaricum .
Bergenin (1), a unique fused C-glycoside isolated from Bergenia species, possesses interesting anti-inflammatory and antipain activities. To study SAR of this scaffold, first-generation derivatives were synthesized evaluated for inhibition lymphocyte proliferation production pro-inflammatory cytokines. The C-7 substituted showed IL-6 as well TNF-α production. its most potent inhibitor 4e 4f then investigated in panel vitro vivo inflammation/arthritis models. These compounds significantly...
Two known naphthocoumarins, chrysomycins A (1) and B (2), along with one new naphthocoumarin chrysomycin C (3) were isolated from the antimicrobial strain of Streptomyces sporoverrucosus (MTCC11715) (isolated soil samples Jammu hills) characterized. The structure compound 3 was established 2D-NMR data. Chrysomycins (2) identified using a strategic HPLC–PDA/LCMS Dictionary Natural Products (DNP) based fast dereplication. Additionally, two D E LCMS, UV DNP information. A–C (1–3) for first time...
Abstract Here we report a facile method for the synthesis of nickel oxide‐nickel (NiO@Ni) Mott‐Schottky catalyst employing metal‐organic framework (MOF) as precursor. A direct amidation protocol aldehydes with amines has been optimized under mild conditions using NiO@Ni and it shows far better catalytic activity than NiO−Ni nanoparticles prepared from simple Ni 2+ salt similar reaction conditions. The heterogeneous is robust, recyclable efficient to provide comparable yield costly...