A5047945934- Microbial Natural Products and Biosynthesis
- Fungal Biology and Applications
- Catalytic C–H Functionalization Methods
- Natural product bioactivities and synthesis
- Marine Sponges and Natural Products
- Synthesis and Catalytic Reactions
- Chemical Synthesis and Analysis
- Traditional Chinese Medicine Analysis
- Ginger and Zingiberaceae research
- Plant tissue culture and regeneration
- Chemical Synthesis and Reactions
- Oxidative Organic Chemistry Reactions
- Natural Compound Pharmacology Studies
- Bioactive Compounds and Antitumor Agents
- Phytochemistry and Biological Activities
- Biological Activity of Diterpenoids and Biflavonoids
- Plant biochemistry and biosynthesis
- Plant-based Medicinal Research
- Intracerebral and Subarachnoid Hemorrhage Research
- Synthesis of Organic Compounds
- Toxin Mechanisms and Immunotoxins
- Acute Ischemic Stroke Management
- Sulfur-Based Synthesis Techniques
- Synthesis and Biological Activity
- Sepsis Diagnosis and Treatment
Institute of Genomics and Integrative Biology
2021-2024
Baylor College of Medicine
2024
Indian Institute of Integrative Medicine
2014-2023
Guru Nanak Dev University
2018-2023
Council of Scientific and Industrial Research
2013-2021
Nanaji Deshmukh Veterinary Science University
2021
Academy of Scientific and Innovative Research
2014-2019
University of Jammu
2014
A novel and efficient method for the synthesis of α-ketoamides, employing a dimethyl sulfoxide (DMSO)-promoted oxidative amidation reaction between 2-oxoaldehydes amines under metal-free conditions is presented. Furthermore, mechanistic studies supported an iminium ion-based intermediate as central feature wherein C1-oxygen atom α-ketoamides finally derived from DMSO.
Present study relates to the effect of valproic acid, an epigenetic modifier on metabolic profile Aspergillus fumigatus (GA-L7), endophytic fungus isolated from Grewia asiatica L. Seven secondary metabolites were A. (GA-L7) which identified as: pseurotin A, D, F2, fumagillin, tryprostatin C, gliotoxin and bis(methylthio)gliotoxin. Addition acid in growth medium resulted alteration with enhanced production a metabolite, fumiquinazoline C by tenfolds. In order assess biosynthetic pathway we...
We present a metal-free method for the synthesis of imides by direct coupling NH-amides with methylarenes under iodine/aqueous TBHP conditions. The optimized conditions worked very well benzaldehydes and benzyl alcohol furnished corresponding in good to excellent yields. A series control radical scavenger experiments were also performed, which suggested involvement pathways. labeling experiment presence 18O-labeled H2O water as source oxygen imides.
Plants effectively defend themselves against biotic and abiotic stresses by synthesizing diverse secondary metabolites, including health-protective flavonoids. These display incredible chemical diversity ubiquitous occurrence confer impeccable biological agricultural applications. Chalcone synthase (CHS), a type III plant polyketide synthase, is critical for flavonoid biosynthesis. It catalyzes acyl-coenzyme A thioesters to synthesize naringenin chalcone through polyketidic intermediate. The...
To explore the potential of Rosellinia sanctae-cruciana an endophytic fungus associated with Albizia lebbeck for pharmaceutically important cytotoxic compounds.One novel cytochalasin, named jammosporin A (1) and four known analogues (2-5) were isolated from culture R. sanctae-cruciana, harboured leaves medicinal plant A. lebbeck. Their structures elucidated by extensive spectroscopic analyses including one-dimensional two-dimensional nuclear magnetic resonance data along MS comparison...
Four novel lipovelutibols A (1), B (2), C (3), and D (4) containing six amino acid residues with leucinol at the C-terminus a fatty acyl moiety (n-octanoyl) its N-terminus were isolated from psychrotrophic fungus Trichoderma velutinum collected Himalayan cold habitat. The structures (1–4) determined by NMR MS/MS, stereochemistry of acids Marfey's method. Lipopeptaibols 2 4 found to contain d-isovaline, nonproteinogenic acid, but lacked α-aminoisobutyric characteristic peptaibols. Cytotoxic...
Two known naphthocoumarins, chrysomycins A (1) and B (2), along with one new naphthocoumarin chrysomycin C (3) were isolated from the antimicrobial strain of Streptomyces sporoverrucosus (MTCC11715) (isolated soil samples Jammu hills) characterized. The structure compound 3 was established 2D-NMR data. Chrysomycins (2) identified using a strategic HPLC–PDA/LCMS Dictionary Natural Products (DNP) based fast dereplication. Additionally, two D E LCMS, UV DNP information. A–C (1–3) for first time...
Targeting the main three networking systems, viz. Las, RhI, and PQS, via natural quenchers is a new ray of hope for combating persistent behavior Pseudomonas aeruginosa. In bacterial chemical vocabulary pyocyanin, N-AHLs rhamnolipids are keywords, which responsible social nomadic P. present work, LC-MS based real-time qualitative quantitative analysis green phenazine, N-AHLs, were performed on aeruginosa PAO1. The indicates that production pyocyanin NHSLs increases with time while...
An efficient BCl3-mediated reaction of imidazo[1,2-a]pyridines has been developed for the C-N, C-S, and C-O bond formation. The salient features this method correspond to substitution different nucleophiles via in situ unconventional debenzylation. process is applicable synthesis a wide variety ((3-amino/thio/alkoxy)-methyl)-imidazo[1,2-a]pyridines.
Disease caused by SARS-CoV-2 coronavirus (COVID-19) led to significant morbidity and mortality worldwide. A systemic hyper-inflammation characterizes severe COVID-19 disease, often associated with acute respiratory distress syndrome (ARDS). Blood biomarkers capable of risk stratification are great importance in effective triage critical care patients. Flow cytometry next-generation sequencing were done on peripheral blood cells urokinase-type plasminogen activator receptor (suPAR), cytokines...
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