A5009978167- Enzyme Catalysis and Immobilization
- Microbial Metabolic Engineering and Bioproduction
- Breast Cancer Treatment Studies
- Esophageal and GI Pathology
- Gastroesophageal reflux and treatments
- Analytical Chemistry and Chromatography
- Epigenetics and DNA Methylation
- Estrogen and related hormone effects
- Hernia repair and management
- Myasthenia Gravis and Thymoma
- MRI in cancer diagnosis
- Appendicitis Diagnosis and Management
- Gallbladder and Bile Duct Disorders
- Breast Lesions and Carcinomas
- Medical Imaging Techniques and Applications
- Eosinophilic Esophagitis
- Microbial metabolism and enzyme function
- Cardiac, Anesthesia and Surgical Outcomes
- Advanced MRI Techniques and Applications
- Geological and Geochemical Analysis
- Surgical Simulation and Training
- Gastrointestinal disorders and treatments
- X-ray Diffraction in Crystallography
- Pituitary Gland Disorders and Treatments
- Salivary Gland Tumors Diagnosis and Treatment
All India Institute of Medical Sciences
2016-2025
Vardhman Mahavir Medical College & Safdarjung Hospital
2025
All India Institute of Medical Sciences Bhopal
2008-2024
All India Institute of Medical Sciences Raipur
2008-2024
Banaras Hindu University
2024
Institute of Medical Sciences
2024
Geological Survey of India
2015-2023
Indian Institute of Integrative Medicine
2005-2022
University of Petroleum and Energy Studies
2015-2017
Council of Scientific and Industrial Research
2001-2013
The DNA methylation mediated by specific methyltransferases (DNMTs), results in the epigenetic silencing of multiple genes which are implicated human breast cancer. We hypothesized that natural compounds modulate expression DNMTs and their associated proteins cancer cell lines affect gene silencing.The transcript was analyzed reverse transcription-polymerase chain reaction (RT-PCR) tumors adjacent normal tissues patients with invasive ductal carcinoma. tested hypothesis compounds, viz.,...
Cancer progression is linked to a partially dedifferentiated epithelial cell phenotype. The signaling pathways Wnt, Hedgehog, TGF-beta and Notch have been implicated in experimental developmental mesenchymal transition (EMT). Recent findings from our laboratory confirm that active Wnt/beta-catenin critically involved invasive ductal carcinomas (IDCs) of breast.In the current study, we analyzed expression patterns relationships between key components- E-cadherin, Slug GSK3beta IDCs breast.Of...
The lipase-producing strain, Arthrobacter sp. (ABL), isolated was immobilized in Ca-alginate beads by entrapment. alginate were prepared as an aqueous mixture of sodium alginate, the cells and CaCl 2 to increase its reusability, overall enzyme stability. Various parameters like concentration, lipase units loading bead size evaluated for optimum immobilization yield. It observed that with yield also increased up a limit. A similar pattern addition; concentrations 1.5% (w/v) 2%, respectively....
The potential of total choline (tCho) signal-to-noise ratio (SNR) (ChoSNR) and tumor volume in the assessment response locally advanced breast cancer (LABC) patients (n = 30) undergoing neoadjuvant chemotherapy (NACT) was investigated using magnetic resonance spectroscopic imaging (MRSI) conventional MRI at 1.5 T. Experiments were carried out sequentially four time-points: prior to therapy after I, II III NACT ChoSNR, measured. MR compared with clinical response. Sequential data 25...
The role of apparent diffusion coefficient (ADC) in the diagnosis breast cancer and its association with molecular biomarkers was investigated 259 patients cancer, 67 benign pathology, 54 healthy volunteers using diffusion-weighted imaging (DWI) at 1.5 T. In 59 patients, dynamic contrast-enhanced MRI (DCEMRI) also acquired. Mean ADC malignant lesions significantly lower (1.02 ± 0.17 × 10(-3) mm(2)/s) compared to (1.57 0.26 (1.78 0.13 tissues. A cutoff value 1.23 mm(2)/s (sensitivity 92.5%;...
Background: Laparo-endoscopic hernia surgery is recommended by various international bodies. However, its uptake general surgeon low. We aim to assess the impact of Three Dimensional (3D) endovision system in learning laparoscopic transabdominal preperitoneal (TAPP) repair groin and transferability skills acquired from 3D Two (2D) environment. Methodology: Senior resident doctor with no previous experience did 20 consecutive cases TAPP using followed another five 2D system. Total operating...
Breast cancer is the most common malignancy diagnosed in women worldwide. Triple-negative breast (TNBC) aggressive subtype, accounting for nearly one third of all cancers India. The addition pembrolizumab to neoadjuvant chemotherapy improved pathological response and event free survival patients with TNBC. However, low- middle-income countries, immunotherapy remains inaccessible due its high cost. Pharmacological early clinical data suggest that a lower dose may be effective. there are no...
Introduction: Cardiac myxomas are the most common primary cardiac neoplasm (30-50%) with clinical incident of 0.5/ million population. Tranthoracic echocardiography remains investigation choice. Surgical excision is curative. The present study aims to analyze demographic and characteristics as well surgical outcomes in terms mortality recurrence myxoma. Methods: Thirty patients myxoma who met inclusion criteria during period period, January-2018 April-2024 were included. Data was analyzed...
Abstract Background Patients with acute bleeding from internal haemorrhoids often have to be referred by the general practitioner surgeon for definitive treatment invasive outpatient procedures. At initial consultation, patients frequently seek postponement of immediate surgery a more convenient time. Effective and rapid non-invasive control could practical use in scheduling time both patient surgeon. Methods In 90-day randomized, double-blind study micronized purified flavonoid fraction...
AbstractBreast cancer is fast emerging as the leading amongst females, especially in young females metropolitan cities India. The epigenetic alterations involved onset and progression of breast may serve biomarkers for early detection prognosis disease. Furthermore, using body fluids such serum offers a non-invasive method to procure multiple samples analyses. In this study, we examined methylation status two normally unmethylated but biologically significant genes, RAS association domain...
Identification of biomarkers for monitoring efficacy neoadjuvant chemotherapy in breast cancer patients is utmost importance individual tailoring treatment and save from toxicity due to non-effective drugs. We hypothesized that methylation circulating tumor-specific DNA may reflect changes tumor burden response help stratify responders non-responders. The aim this study was evaluate the potential monitor patients. Six consecutive sera samples collected 30 undergoing were analyzed status a...
Abstract The association of estrogen receptor, progesterone and human epidermal growth factor receptor 2 (HER2) status breast cancer patients with total choline (tCho) concentration tumor volume was investigated using in vivo proton magnetic resonance spectroscopy MRI at 1.5 T. Values for tCho were determined 120 locally advanced (stages IIB, IIIA, IIIB, IIIC), 31 early (stage IIA), 38 benign lesions, 37 controls. Significantly higher lower observed compared to ( P < 0.05). did not...
The Androgen Receptor (AR) has emerged as an endocrine therapy target in Breast Cancer, exhibiting up to 80% expression clinical cases. AR-V7, a constitutively activated splice variant of AR with truncated ligand-binding domain (LBD), demonstrates ligand-independent transcriptional activity and resistance nonsteroidal antiandrogens like Bicalutamide or Enzalutamide, targeting the LBD. In metastatic prostate cancer, elevated AR-V7 levels lead therapeutic increased metastasis. this study, we...
Although day care laparoscopic cholecystectomy (DCLC) has been shown to be safe in centres with adequate infrastructure for surgery, its feasibility and safety developing countries never studied. Because of differences the quality health delivery, western guidelines surgery cannot universally applied countries.Patients less than 65 years who were graded I II on American Society Anesthesiologists physical status score, irrespective their educational status, living within 20 km, willing make...
Methylation-mediated suppression of detoxification, DNA repair and tumor suppressor genes has been implicated in cancer development. This study was designed to investigate the impact concurrent methylation multiple breast tumors on disease prognosis. Methylation specific PCR carried out analyze status seven archived tissues determine effect aberrant prognosis patients' survival. Promoter hypermethylation observed PRB 67%, ERalpha 64%, RASSF1A 63%, p16INK4A 51%, RARbeta2 22%, GSTP1 25% BRCA1...